Arrieta O, Aviles-Salas A, Orozco-Morales M, Hernández-Pedro N, Cardona AF, Cabrera-Miranda L, et al. Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancer. Cancer Med. 2020;9(7):2390–402.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shi M, Gu Y, Jin K, Fang H, Chen Y, Cao Y, et al. CD47 expression in gastric cancer clinical correlates and association with macrophage infiltration. Cancer Immunol Immunother CII. 2021;70(7):1831–40.
Article
CAS
PubMed
Google Scholar
Kim H, Jee S, Kim Y, Sim J, Bang S, Son HK, et al. Correlation of CD47 expression with adverse clinicopathologic features and an unfavorable prognosis in colorectal adenocarcinoma. Diagnostics (Basel, Switzerland). 2021;11(4):668.
CAS
Google Scholar
Imam R, Chang Q, Black M, Yu C, Cao W. CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor. BMC Cancer. 2021;21(1):320.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, et al. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci USA. 2017;114(49):E10578–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chao MP, Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Can Res. 2011;71(4):1374–84.
Article
CAS
Google Scholar
Orozco-Morales M, Avilés-Salas A, Hernández-Pedro N, Catalán R, Cruz-Rico G, Colín-González AL, et al. Clinicopathological and prognostic significance of CD47 expression in lung neuroendocrine tumors. J Immunol Res. 2021;2021:6632249.
Article
PubMed
PubMed Central
CAS
Google Scholar
Andrejeva G, Capoccia BJ, Hiebsch RR, Donio MJ, Darwech IM, Puro RJ, et al. Novel SIRPα antibodies that induce single-agent phagocytosis of tumor cells while preserving T cells. J Immunol (Baltimore, Md: 1950). 2021;206(4):712–21.
Article
CAS
Google Scholar
Sikic BI, Lakhani N, Patnaik A, Shah SA, Chandana SR, Rasco D, et al. First-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers. J Clin Oncol. 2019;37(12):946–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, et al. CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin’s lymphoma. N Engl J Med. 2018;379(18):1711–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Clinical Trial Results: A Phase 1–2 Study of Ti-061 Alone and in combination with other anti-cancer agents in Patients with Advanced Malignancies. https://www.clinicaltrialsregistereu/ctr-search/trial/2016-004372-22/results. Accessed 30 Aug 2021.
Sallman DA, Donnellan WB, Asch AS, et al. The first-in-class anti-CD47 antibody Hu5F9-G4 is active and well tolerated alone or with azacitidine in AML and MDS patients: initial phase 1b results. J Clin Oncol. 2019;37(15_suppl):7009.
Article
Google Scholar
Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N, et al. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol. 1996;16(12):6887–99.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oshima K, Ruhul Amin AR, Suzuki A, Hamaguchi M, Matsuda S. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002;519(1–3):1–7.
Article
CAS
PubMed
Google Scholar
Timms JF, Swanson KD, Marie-Cardine A, Raab M, Rudd CE, Schraven B, et al. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr Biol CB. 1999;9(16):927–30.
Article
CAS
PubMed
Google Scholar
Johansen ML, Brown EJ. Dual regulation of SIRPalpha phosphorylation by integrins and CD47. J Biol Chem. 2007;282(33):24219–30.
Article
CAS
PubMed
Google Scholar
Adams S, van der Laan LJ, Vernon-Wilson E, Renardel de Lavalette C, Döpp EA, Dijkstra CD, et al. Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol (Baltimore, Md: 1950). 1998;161(4):1853–9.
CAS
Google Scholar
Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 2001;11(3):130–5.
Article
CAS
PubMed
Google Scholar
Logtenberg MEW, Scheeren FA, Schumacher TN. The CD47-SIRPα immune checkpoint. Immunity. 2020;52(5):742–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reinhold MI, Lindberg FP, Plas D, Reynolds S, Peters MG, Brown EJ. In vivo expression of alternatively spliced forms of integrin-associated protein (CD47). J Cell Sci. 1995;108(Pt 11):3419–25.
Article
CAS
PubMed
Google Scholar
Jiang P, Lagenaur CF, Narayanan V. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem. 1999;274(2):559–62.
Article
CAS
PubMed
Google Scholar
Lindberg FP, Gresham HD, Reinhold MI, Brown EJ. Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding. J Cell Biol. 1996;134(5):1313–22.
Article
CAS
PubMed
Google Scholar
Vernon-Wilson EF, Kee WJ, Willis AC, Barclay AN, Simmons DL, Brown MH. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol. 2000;30(8):2130–7.
Article
CAS
PubMed
Google Scholar
Han X, Sterling H, Chen Y, Saginario C, Brown EJ, Frazier WA, et al. CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation. J Biol Chem. 2000;275(48):37984–92.
Article
CAS
PubMed
Google Scholar
Yamao T, Noguchi T, Takeuchi O, Nishiyama U, Morita H, Hagiwara T, et al. Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. J Biol Chem. 2002;277(42):39833–9.
Article
CAS
PubMed
Google Scholar
Lutz HU, Bogdanova A. Mechanisms tagging senescent red blood cells for clearance in healthy humans. Front Physiol. 2013;4:387.
Article
PubMed
PubMed Central
Google Scholar
Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009;138(2):271–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sun C, Mezzadra R, Schumacher TN. Regulation and function of the PD-L1 checkpoint. Immunity. 2018;48(3):434–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536(7614):86–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wernig G, Chen SY, Cui L, Van Neste C, Tsai JM, Kambham N, et al. Unifying mechanism for different fibrotic diseases. Proc Natl Acad Sci USA. 2017;114(18):4757–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li Z, Li Y, Gao J, Fu Y, Hua P, Jing Y, et al. The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy. Life Sci. 2021;273:119150.
Article
CAS
PubMed
Google Scholar
Noman MZ, Van Moer K, Marani V, Gemmill RM, Tranchevent LC, Azuaje F, et al. CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT. Oncoimmunology. 2018;7(4):e1345415.
Article
PubMed
PubMed Central
Google Scholar
Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, et al. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proc Natl Acad Sci USA. 2015;112(45):E6215–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kaur S, Cicalese KV, Bannerjee R, Roberts DD. Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment. Antibody Ther. 2020;3(3):179–92.
Article
CAS
Google Scholar
Chao MP, Takimoto CH, Feng DD, McKenna K, Gip P, Liu J, et al. Therapeutic targeting of the macrophage immune checkpoint CD47 in myeloid malignancies. Front Oncol. 2019;9:1380.
Article
PubMed
Google Scholar
Dong X, Han Y, Liu Y, Yang L, Niu H, Yan L, et al. Phagocytosis checkpoints on hematopoietic stem cells in patients with myelodysplastic syndromes. Asia-Pacific J Clin Oncol. 2021. https://doi.org/10.1111/ajco.13566.
Article
Google Scholar
Bruce LJ, Ghosh S, King MJ, Layton DM, Mawby WJ, Stewart GW, et al. Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex. Blood. 2002;100(5):1878–85.
Article
CAS
PubMed
Google Scholar
Lindberg FP, Gresham HD, Schwarz E, Brown EJ. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J Cell Biol. 1993;123(2):485–96.
Article
CAS
PubMed
Google Scholar
Kaur S, Kuznetsova SA, Pendrak ML, Sipes JM, Romeo MJ, Li Z, et al. Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1. J Biol Chem. 2011;286(17):14991–5002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dahl KN, Westhoff CM, Discher DE. Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes. Blood. 2003;101(3):1194–9.
Article
CAS
PubMed
Google Scholar
McDonald JF, Zheleznyak A, Frazier WA. Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity. J Biol Chem. 2004;279(17):17301–11.
Article
CAS
PubMed
Google Scholar
Peluso MO, Adam A, Armet CM, Zhang L, O’Connor RW, Lee BH, et al. The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a. J Immunother Cancer. 2020;8(1):e000413.
Article
PubMed
PubMed Central
Google Scholar
Upton R, Banuelos A, Feng D, Biswas T, Kao K, McKenna K, et al. Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance. Proc Natl Acad Sci USA. 2021;118(29):e2026849118.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kuo TC, Chen A, Harrabi O, Sockolosky JT, Zhang A, Sangalang E, et al. Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity. J Hematol Oncol. 2020;13(1):160.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang Z, Luo F, Cao J, Lu F, Zhang Y, Ma Y, et al. Anticancer bispecific antibody R&D advances: a study focusing on research trend worldwide and in China. J Hematol Oncol. 2021;14(1):124.
Article
PubMed
PubMed Central
Google Scholar
Dheilly E, Majocchi S, Moine V, Didelot G, Broyer L, Calloud S, et al. Tumor-directed blockade of CD47 with bispecific antibodies induces adaptive antitumor immunity. Antibodies (Basel, Switzerland). 2018;7(1):3.
CAS
Google Scholar
Lu Q, Chen X, Wang S, Lu Y, Yang C, Jiang G. Potential new cancer immunotherapy: anti-CD47-SIRPα antibodies. OncoTargets Ther. 2020;13:9323–31.
Article
CAS
Google Scholar
Russ A, Hua AB, Montfort WR, Rahman B, Riaz IB, Khalid MU, et al. Blocking “don’t eat me” signal of CD47-SIRPα in hematological malignancies, an in-depth review. Blood Rev. 2018;32(6):480–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Narla RK, Modi H, Bauer D, Abbasian M, Leisten J, Piccotti JR, et al. Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody. Cancer Immunol Immunother CII. 2021. https://doi.org/10.1007/s00262-021-03010-6.
Article
PubMed
Google Scholar
Liu J, Wang L, Zhao F, Tseng S, Narayanan C, Shura L, et al. Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PLoS ONE. 2015;10(9):e0137345.
Article
PubMed
PubMed Central
CAS
Google Scholar
Buatois V, Johnson Z, Salgado-Pires S, Papaioannou A, Hatterer E, Chauchet X, et al. Preclinical development of a bispecific antibody that safely and effectively targets CD19 and CD47 for the treatment of B-cell lymphoma and leukemia. Mol Cancer Ther. 2018;17(8):1739–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K, et al. TTI-621 (SIRPαFc): a CD47-blocking innate immune checkpoint inhibitor with broad antitumor activity and minimal erythrocyte binding. Clin Cancer Res. 2017;23(4):1068–79.
Article
CAS
PubMed
Google Scholar
Velliquette RW, Aeschlimann J, Kirkegaard J, Shakarian G, Lomas-Francis C, Westhoff CM. Monoclonal anti-CD47 interference in red cell and platelet testing. Transfusion. 2019;59(2):730–7.
Article
CAS
PubMed
Google Scholar
Advani R, Bartlett NL, Smith SM, Roschewski M, Popplewell L, Flinn I, Collins G, Ghosh N, LaCasce A, Asch A, Kline J, Kesevan M, Tran T, Lynn J, Huang J, Agoram B, Volkmer J, Takimoto CH, Chao MP, Mehta A. The first-in-class anti-CD47 antibody HU5F9-G4 + rituximab induces durable responses in relapsed/refractory DLBCL and indolent lymphoma: interim phase 1B/2 results. Hematol Oncol. 2019;37(S2):89–90. https://doi.org/10.1002/hon57_2629.
Article
Google Scholar
Ansell SM, Maris MB, Lesokhin AM, Chen RW, Flinn IW, Sawas A, et al. Phase I study of the CD47 blocker TTI-621 in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2021;27(8):2190–9.
Article
CAS
PubMed
Google Scholar
Uger R, Johnson L. Blockade of the CD47-SIRPα axis: a promising approach for cancer immunotherapy. Expert Opin Biol Ther. 2020;20(1):5–8.
Article
CAS
PubMed
Google Scholar
Krish Patel MBM, Bruce D. Cheson, Jeffrey A. Zonder, Alexander M. Lesokhin, Gottfried Von Keudell, Erlene Kuizon Seymour, Gloria H.Y. Lin, Tina Catalano, Yaping Shou, Swaminathan Padmanabhan Iyer, Radhakrishnan Ramchandren. Ongoing, first-in-human, phase I dose escalation study of the investigational CD47-blocker TTI-622 in patients with advanced relapsed or refractory lymphoma. 2020. https://meetings.asco.org/abstracts-presentations/188624.
Lisa Johnson RKP, Rebecca L. King, Stephen Maxted Ansell, Robert W. Chen, Ian Flinn, Michael B. Maris, Meghan Irwin, Eric L. Sievers, Penka S. Petrova, Robert A. Uger. Effects of TTI-621 (SIRPαFc) on CD47 and serum cytokines associated with phagocytosis in subjects with relapsed, refractory hematologic malignancies: pharmacodynamic findings from a first-in-human clinical trial. ASCO meeting abstract. 2017. https://meetings.asco.org/abstracts-presentations/140876.
Kim TM, Lakhani N, Gainor J, Kamdar M, Fanning P, Squifflet P, Jin F, Wan H, Pons J, Randolph SS, Kim WS. A phase 1 study of ALX148, a CD47 blocker, in combination with rituximab in patients with non-Hodgkin lymphoma. Blood. 2019;134(Supplement_1):1953.
Article
Google Scholar
Kauder SE, Kuo TC, Harrabi O, Chen A, Sangalang E, Doyle L, et al. ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile. PLoS ONE. 2018;13(8):e0201832.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chow LQMGJ, Lakhani NJ, et al. A phase I study of ALX148, a CD47 blocker, in combination with established anticancer antibodies in patients with advanced malignancy. J Clin Oncol. 2019;37(15_suppl):2514.
Article
Google Scholar
Chow LQM, Gainor JF, Lakhani NJ, Lee KW, Chung HC, Lee J, LoRusso P, Bang Y-J, Hodi FS, Davila RS, Fanning P, Squifflet P, Jin F, Wan H, Kuo T, Pons J, Randolph S, Messersmith WA. A phase I study of ALX148, a CD47 blocker, in combination with standard anticancer antibodies and chemotherapy regimens in patients with advanced malignancy. 2020. https://meetings.asco.org/abstracts-presentations/189180.
ALX Oncology Announces Data from ASPEN-01, ALX148 Demonstrates Robust Objective Response in Patients with Gastric or Gastroesophageal Junction Cancer. https://trialsitenews.com/alx-oncology-announces-data-from-aspen-01-alx148-demonstrates-robust-objective-response-in-patients-with-gastric-or-gastroesophageal-junction-cancer/. Accessed 30 Aug 2021
Puro RJ, Bouchlaka MN, Hiebsch RR, Capoccia BJ, Donio MJ, Manning PT, et al. Development of AO-176, a next-generation humanized anti-CD47 antibody with novel anticancer properties and negligible red blood cell binding. Mol Cancer Ther. 2020;19(3):835–46.
Article
CAS
PubMed
Google Scholar
Burris HA III AIS, Taylor MH, Yeku OO, Liu JF, Munster PN, Hamilton EP, Thomas JS, Gatlin F, Penson RT, Abrams TA, Dhawan MS, Walling JM, Frye JW, Romanko K, Sung V, Brachmann C, El-Khoueiry AB. A first-in-human study of AO-176, a highly differentiated anti-CD47 antibody, in patients with advanced solid tumors. 2021. https://meetings.asco.org/abstracts-presentations/199338.
TG Therapeutics provides update on its clinical programs. https://irtgtherapeutics.com/news-releases/news-release-details/tg-therapeutics-announces-initiation-phase-i-first-human. Accessed 30 Aug 2021.
Champiat S, Kotecki N, Korakis I, Vinceneux A, Jungels C, Blatchford J, Elgadi MM, Clarke N, Fromond C, Poirier N, Vasseur B, Marabelle A, Delord J-P. Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in-class BI 765063, a selective SIRPα inhibitor: results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors. 2021. https://meetings.asco.org/abstracts-presentations/196073.
Kahrbio provides update on its clinical programs. https://kahrbio.com/kahr-announces-first-patient-dosed-in-phase-1-2-clinical-trial-of-dsp107-bi-functional-cd47x41bb-candidate-for-the-treatment-of-solid-tumors/. Accessed 30 Aug 2021.
ImmuneOncia provides update on its clinical programs. https://www.prnewswire.com/news-releases/immuneoncia-and-3d-medicines-signed-exclusive-license-agreement-to-develop-manufacture-and-commercialize-imc-002-in-greater-china-301258121html. Accessed 30 Aug 2021.
Qi J, Li J, Jiang B, Jiang B, Liu H, Cao X, Zhang M, Meng Y, Xiaoyu MA, Jia Y, Guo J. A phase I/IIa study of lemzoparlimab, a monoclonal antibody targeting CD47, in patients with relapsed and/or refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): initial phase i results. Blood. 2020;136(Supplement 1):30–1. https://doi.org/10.1182/blood-2020-134391.
Article
Google Scholar
Ni H, Cao L, Wu Z, Wang L, Zhou S, Guo X, et al. Combined strategies for effective cancer immunotherapy with a novel anti-CD47 monoclonal antibody. Cancer Immunol Immunother CII. 2021. https://doi.org/10.1007/s00262-021-02989-2.
Article
PubMed
Google Scholar
Wang Y, Pan D, Huang C, Chen B, Li M, Zhou S, et al. Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody. MAbs. 2020;12(1):1748322.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wang Y, Ni H, Zhou S, He K, Gao Y, Wu W, et al. Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity. Cancer Immunol Immunother CII. 2021;70(2):365–76.
Article
CAS
PubMed
Google Scholar
Roohullah A, Ganju V, Zhang F, Zhang L, Yu T, Wilkinson K, Cooper A, de Souza P. First-in-human phase 1 dose escalation study of HX009, a novel recombinant humanized anti-PD-1 and CD47 bispecific antibody, in patients with advanced malignancies. 2021. https://meetinglibrarya.sco.org/record/196007/abstract.
ImmuneOnco provides update on its clinical programs. http://immuneonco.com/displayphp?id=121. Accessed 30 Aug 2021.
Gan HK, Coward J, Mislang ARA, Cosman R, Nagrial A, Jin X, Li B, Wang ZM, Kwek KY, Xia D, Xia Y. Safety of AK117, an anti-CD47 monoclonal antibody, in patients with advanced or metastatic solid tumors in a phase I study. ASCO meeting abstract. 2021. https://meetings.asco.org/abstracts-presentations/196167.
Gao Y, Zhang D, Yang C, Duan X, Li X, Zhong D. Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method. J Pharm Biomed Anal. 2019;175:112792.
Article
CAS
PubMed
Google Scholar
CSPC Pharmaceutical provides update on its clinical programs. https://docirasia.com/listco/hk/cspc/announcement/ca210329pdf. Accessed 30 Aug 2021.
Zhao W, Hu X, Li W, Li R, Chen J, Zhou L, et al. M2-like TAMs function reversal contributes to breast cancer eradication by combination dual immune checkpoint blockade and photothermal therapy. Small. 2021;17(13):e2007051.
Article
PubMed
CAS
Google Scholar
Chen SH, Dominik PK, Stanfield J, Ding S, Yang W, Kurd N, et al. Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity. J Immunother Cancer. 2021;9(10):e003464.
Article
PubMed
PubMed Central
Google Scholar
Zhang A, Ren Z, Tseng KF, Liu X, Li H, Lu C, et al. Dual targeting of CTLA-4 and CD47 on T(reg) cells promotes immunity against solid tumors. Sci Transl Med. 2021. https://doi.org/10.1126/scitranslmed.abg8693.
Article
PubMed
PubMed Central
Google Scholar
Yu J, Song Y, Tian W. How to select IgG subclasses in developing anti-tumor therapeutic antibodies. J Hematol Oncol. 2020;13(1):45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Anniss AM, Sparrow RL. Expression of CD47 (integrin-associated protein) decreases on red blood cells during storage. Transfus Apheresis Sci. 2002;27(3):233–8.
Article
Google Scholar
Khandelwal S, van Rooijen N, Saxena RK. Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation. Transfusion. 2007;47(9):1725–32.
Article
PubMed
Google Scholar
Weiskopf K. Cancer immunotherapy targeting the CD47/SIRPα axis. Eur J Cancer (Oxford, England: 1990). 2017;76:100–9.
Article
CAS
Google Scholar
Barclay AN, Brown MH. The SIRP family of receptors and immune regulation. Nat Rev Immunol. 2006;6(6):457–64.
Article
CAS
PubMed
Google Scholar
Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, et al. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat Med. 2019;25(4):612–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen Q, Wang C, Zhang X, Chen G, Hu Q, Li H, et al. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat Nanotechnol. 2019;14(1):89–97.
Article
CAS
PubMed
Google Scholar
Liu Q, Wen W, Tang L, Qin CJ, Lin Y, Zhang HL, et al. Inhibition of SIRPα in dendritic cells potentiates potent antitumor immunity. Oncoimmunology. 2016;5(9):e1183850.
Article
PubMed
PubMed Central
CAS
Google Scholar
Tahk S, Vick B, Hiller B, Schmitt S, Marcinek A, Perini ED, et al. SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells. J Hematol Oncol. 2021;14(1):155.
Article
PubMed
PubMed Central
Google Scholar