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  1. HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively act...

    Authors: Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz and Christophe Nicot
    Citation: Journal of Hematology & Oncology 2018 11:119
    Content type: Research Published on:

  2. Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in th...

    Authors: Min Su, Yuhang Xiao, Junliang Ma, Deliang Cao, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang
    Citation: Journal of Hematology & Oncology 2018 11:118
    Content type: Review Published on:

  3. Platelet glycoprotein Ibα (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in ...

    Authors: Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu and Xin Liang
    Citation: Journal of Hematology & Oncology 2018 11:117
    Content type: Research Published on:

  4. During the past decade, the three-dimensional organoid technology has sprung up and become more and more popular among researchers. Organoids are the miniatures of in vivo tissues and organs, and faithfully re...

    Authors: Hanxiao Xu, Xiaodong Lyu, Ming Yi, Weiheng Zhao, Yongping Song and Kongming Wu
    Citation: Journal of Hematology & Oncology 2018 11:116
    Content type: Review Published on:

  5. Recently, many potential prognostic biomarkers for gastric cancer (GC) have been identified, but the prognosis of advanced GC patients remains poor. Chloride channels are promising cancer biomarkers, and their...

    Authors: Zhuoyu Gu, Yixin Li, Xiaoya Yang, Meisheng Yu, Zhanru Chen, Chan Zhao, Lixin Chen and Liwei Wang
    Citation: Journal of Hematology & Oncology 2018 11:115
    Content type: Research Published on:

  6. Distant metastasis is initiated by circulating tumor cells (CTCs), which are considered to be a determining factor for the degree of metastasis and the survival of cancer patients. Although CTC-based diagnosti...

    Authors: Yi Rang Kim, Jung Ki Yoo, Chang Wook Jeong and Jin Woo Choi
    Citation: Journal of Hematology & Oncology 2018 11:114
    Content type: Letter to the Editor Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2019 12:5

  7. The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been reported to be overexpressed in colorectal cancer (CRC). However, its underlying mechanisms in the progression of CRC have not bee...

    Authors: Meng Zhang, Weiwei Weng, Qiongyan Zhang, Yong Wu, Shujuan Ni, Cong Tan, Midie Xu, Hui Sun, Chenchen Liu, Ping Wei and Xiang Du
    Citation: Journal of Hematology & Oncology 2018 11:113
    Content type: Research Published on:

  8. Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such ...

    Authors: Simon Heine, Markus Kleih, Neus Giménez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip and Elisabeth Silkenstedt
    Citation: Journal of Hematology & Oncology 2018 11:112
    Content type: Research Published on:

  9. Histone acetylation and deacetylation are important epigenetic mechanisms that regulate gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only part...

    Authors: Ting Li, Chao Zhang, Shafat Hassan, Xinyue Liu, Fengju Song, Kexin Chen, Wei Zhang and Jilong Yang
    Citation: Journal of Hematology & Oncology 2018 11:111
    Content type: Review Published on:

  10. Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploide...

    Authors: Federica Giannotti, Myriam Labopin, Roni Shouval, Jaime Sanz, William Arcese, Emanuele Angelucci, Jorge Sierra, Josep-Maria Ribera Santasusana, Stella Santarone, Bruno Benedetto, Alessandro Rambaldi, Riccardo Saccardi, Didier Blaise, Michele Angelo Carella, Vanderson Rocha, Frederic Baron…
    Citation: Journal of Hematology & Oncology 2018 11:110
    Content type: Research Published on:

  11. No approved targeted agents are available for esophageal squamous cell carcinoma (ESCC). Informative genomic analysis and mouse patient-derived xenografts (PDX) also called mouse avatar can greatly expedite dr...

    Authors: Zhentao Liu, Zuhua Chen, Jingyuan Wang, Mengqi Zhang, Zhongwu Li, Shubin Wang, Bin Dong, Cheng Zhang, Jing Gao and Lin Shen
    Citation: Journal of Hematology & Oncology 2018 11:109
    Content type: Research Published on:

  12. The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL).

    Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan and Jan Cools
    Citation: Journal of Hematology & Oncology 2018 11:108
    Content type: Research Published on:

  13. Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress. In humans, MTs have four ma...

    Authors: Manfei Si and Jinghe Lang
    Citation: Journal of Hematology & Oncology 2018 11:107
    Content type: Review Published on:

  14. Compared with normal cells, tumor cells display distinct metabolic characteristics. Long non-coding RNAs (lncRNAs), a large class of regulatory RNA molecules with limited or no protein-coding capacity, play ke...

    Authors: Hui Sun, Zhaohui Huang, Weiqi Sheng and Mi-die Xu
    Citation: Journal of Hematology & Oncology 2018 11:106
    Content type: Review Published on:

  15. Next-generation sequencing (NGS) of the rearranged immunoglobulin heavy-chain gene has emerged as a highly sensitive method to detect minimal residual disease (MRD) in B acute lymphoblastic leukemia/lymphoma (...

    Authors: Shuhua Cheng, Giorgio Inghirami, Shuo Cheng and Wayne Tam
    Citation: Journal of Hematology & Oncology 2018 11:105
    Content type: Research Published on:

  17. Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Current treatment strategies include the use of growth factors, CD34+-selected st...

    Authors: Cen Tang, Feng Chen, Danqing Kong, Qinfen Ma, Haiping Dai, Jia Yin, Zheng Li, Jia Chen, Xiaming Zhu, Xinliang Mao, Depei Wu and Xiaowen Tang
    Citation: Journal of Hematology & Oncology 2018 11:103
    Content type: Letter to the Editor Published on:

  18. The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer...

    Authors: Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu and Hanmei Xu
    Citation: Journal of Hematology & Oncology 2018 11:102
    Content type: Research Published on:

  19. Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4 anemia and/or thrombocytopenia, necessitating dose reductions a...

    Authors: Moshe Talpaz, Susan Erickson-Viitanen, Kevin Hou, Solomon Hamburg and Maria R. Baer
    Citation: Journal of Hematology & Oncology 2018 11:101
    Content type: Research Published on:

  20. Indoleamine 2, 3-dioxygenases (IDO1 and IDO2) and tryptophan 2, 3-dioxygenase (TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into kynurenine. The depletion of tryptophan and ...

    Authors: Ming Liu, Xu Wang, Lei Wang, Xiaodong Ma, Zhaojian Gong, Shanshan Zhang and Yong Li
    Citation: Journal of Hematology & Oncology 2018 11:100
    Content type: Review Published on:

  21. Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identifi...

    Authors: Andrea Ghelli Luserna Di Rorà, Neil Beeharry, Enrica Imbrogno, Anna Ferrari, Valentina Robustelli, Simona Righi, Elena Sabattini, Maria Vittoria Verga Falzacappa, Chiara Ronchini, Nicoletta Testoni, Carmen Baldazzi, Cristina Papayannidis, Maria Chiara Abbenante, Giovanni Marconi, Stefania Paolini, Sarah Parisi…
    Citation: Journal of Hematology & Oncology 2018 11:99
    Content type: Research Published on:

  22. Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of variou...

    Authors: Yiting Geng, Jingting Jiang and Changping Wu
    Citation: Journal of Hematology & Oncology 2018 11:98
    Content type: Review Published on:

  23. Immune cells were traditionally considered as major pro-inflammatory contributors. Recent advances in molecular immunology prove that immune cell lineages are composed of different subsets capable of a vast ar...

    Authors: Pu Fang, Xinyuan Li, Jin Dai, Lauren Cole, Javier Andres Camacho, Yuling Zhang, Yong Ji, Jingfeng Wang, Xiao-Feng Yang and Hong Wang
    Citation: Journal of Hematology & Oncology 2018 11:97
    Content type: Review Published on:

  24. Recurrent deletions of the CDKN2A/ARF/CDKN2B genes encoded at chromosome 9p21 have been described in both pediatric and adult acute lymphoblastic leukemia (ALL), but their prognostic value remains controversial, ...

    Authors: E. Genescà, A. Lazarenkov, M. Morgades, G. Berbis, N. Ruíz-Xivillé, P. Gómez-Marzo, J. Ribera, J. Juncà, A. González-Pérez, S. Mercadal, R. Guardia, M. T. Artola, M. J. Moreno, J. Martínez-López, L. Zamora, P. Barba…
    Citation: Journal of Hematology & Oncology 2018 11:96
    Content type: Letter to the Editor Published on:

  25. Ubiquitination is a basic post-translational modification for cellular homeostasis, and members of the conjugating enzyme (E2) family are the key components of the ubiquitin–proteasome system. However, the rol...

    Authors: Tong Shen, Ling-Dong Cai, Yu-Hong Liu, Shi Li, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Peng-Da Guo, Qun Zhou, Xing-Xing Lu, Li-Na Sun and Jian-Ming Li
    Citation: Journal of Hematology & Oncology 2018 11:95
    Content type: Research Published on:

  26. The original article [1] contained minor typesetting errors affecting the following authors: Ziang Jeff Gao, Xiao Zhen Zhou, and Kun Ping Lu.

    Authors: Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Gao…
    Citation: Journal of Hematology & Oncology 2018 11:94
    Content type: Correction Published on:

    The original article was published in Journal of Hematology & Oncology 2018 11:73

  27. Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, w...

    Authors: Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2018 11:93
    Content type: Letter to the Editor Published on:

  28. Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tu...

    Authors: Yali Han, Wei Xie, De-Gang Song and Daniel J. Powell Jr
    Citation: Journal of Hematology & Oncology 2018 11:92
    Content type: Research Published on:

  30. The original article [1] contains a spelling error in the authorship; the authors would like to note the correct spelling of the second author, Jiajia Xi.

    Authors: Qian Huang, Jiajia Xi, Lei Wang, Xu Wang, Xiaodong Ma, Qipan Deng, Yong Lu, Munish Kumar, Zhiyuan Zhou, Ling Li, Zhaoyang Zeng, Ken H. Young, Qing Yi, Mingzhi Zhang and Yong Li
    Citation: Journal of Hematology & Oncology 2018 11:90
    Content type: Correction Published on:

    The original article was published in Journal of Hematology & Oncology 2018 11:58

  31. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation. The long non-coding RNAs (lncRNAs), emerging as key mole...

    Authors: Yang Li, Changqian Zeng, Jialei Hu, Yue Pan, Yujia Shan, Bing Liu and Li Jia
    Citation: Journal of Hematology & Oncology 2018 11:89
    Content type: Research Published on:

  32. The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner regulating the expression of som...

    Authors: Xinwei Huang, Hong Zhang, Xiaoran Guo, Zongxin Zhu, Haibo Cai and Xiangyang Kong
    Citation: Journal of Hematology & Oncology 2018 11:88
    Content type: Review Published on:

  33. Mantle cell lymphoma (MCL) is an aggressive and incurable lymphoma. Standard of care for younger patients with MCL is induction chemotherapy followed by autologous stem cell transplantation (auto-HCT). Rituxim...

    Authors: Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Rosen…
    Citation: Journal of Hematology & Oncology 2018 11:87
    Content type: Research Published on:

  34. Preclinical data have shown that ERBB2 activating mutations are responsive to HER2 tyrosine kinase inhibitors. The aim of this study is to characterize the landscape of ERBB2 mutations in solid tumors and the ...

    Authors: Sophie Cousin, Emmanuel Khalifa, Amandine Crombe, Yech’an Laizet, Carlo Lucchesi, Maud Toulmonde, Sylvestre Le Moulec, Céline Auzanneau, Isabelle Soubeyran and Antoine Italiano
    Citation: Journal of Hematology & Oncology 2018 11:86
    Content type: Letter to the Editor Published on:

  35. Inhibition of metastasis of head and neck squamous cell carcinoma (HNSCC) is one of the most important challenges in cancer treatment. Src, a non-receptor tyrosine kinase, has been implicated as a key promoter...

    Authors: Liwei Lang, Chloe Shay, Yuanping Xiong, Parth Thakkar, Ron Chemmalakuzhy, Xuli Wang and Yong Teng
    Citation: Journal of Hematology & Oncology 2018 11:85
    Content type: Research Published on:

  37. Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becomi...

    Authors: Swathi Balaji, Makhdum Ahmed, Elizabeth Lorence, Fangfang Yan, Krystle Nomie and Michael Wang
    Citation: Journal of Hematology & Oncology 2018 11:83
    Content type: Review Published on:

  38. The initiation and progression of hepatocellular carcinoma (HCC) are largely dependent on its local microenvironment. Adipocytes are an important component of hepatic microenvironment in nonalcoholic fatty liv...

    Authors: Shihua Wang, Meiqian Xu, Xiaoxia Li, Xiaodong Su, Xian Xiao, Armand Keating and Robert Chunhua Zhao
    Citation: Journal of Hematology & Oncology 2018 11:82
    Content type: Research Published on:

  41. Ibrutinib is an oral irreversible inhibitor of Bruton’s tyrosine kinase, indicated for the treatment of chronic lymphocytic leukaemia. The drug is generally well tolerated; however, not infrequent side effects...

    Authors: Gianluigi Reda, Bruno Fattizzo, Ramona Cassin, Veronica Mattiello, Tatiana Tonella, Diana Giannarelli, Ferdinando Massari and Agostino Cortelezzi
    Citation: Journal of Hematology & Oncology 2018 11:79
    Content type: Letter to the Editor Published on:

  43. Despite the overwhelming number of investigations on AKT, little is known about lncRNA on AKT regulation, especially in GBM cells.

    Authors: Changhong Liu, Yan Zhang, Xiaoling She, Li Fan, Peiyao Li, Jianbo Feng, Haijuan Fu, Qing Liu, Qiang Liu, Chunhua Zhao, Yingnan Sun and Minghua Wu
    Citation: Journal of Hematology & Oncology 2018 11:77
    Content type: Research Published on:

  46. Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation an...

    Authors: Nithila A. Joseph, Shiow-Her Chiou, Zoe Lung, Cheng-Lin Yang, Tze-Yi Lin, Hui-Wen Chang, H. Sunny Sun, Sachin Kumar Gupta, Laising Yen, Shulhn-Der Wang and Kuan-Chih Chow
    Citation: Journal of Hematology & Oncology 2018 11:74
    Content type: Research Published on:

  47. The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with the ability to blo...

    Authors: Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Gao…
    Citation: Journal of Hematology & Oncology 2018 11:73
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2018 11:94

  48. Targeting cancer stem cells is critical for suppressing cancer progression and recurrence. Finding novel markers or related pathways could help eradicate or diagnose cancer in clinic.

    Authors: Lufeng Zheng, Chenxi Xiang, Xiaoman Li, Qianqian Guo, Lanlan Gao, Haiwei Ni, Yufeng Xia and Tao Xi
    Citation: Journal of Hematology & Oncology 2018 11:72
    Content type: Research Published on:

  49. Binding of insulin-like growth factor-I (IGF-1) to its receptor (IGF-1R) initiates downstream signals that activate PI3K/Akt/mTOR and MEK/Erk pathways, which stimulate cancer cell proliferation and induce drug...

    Authors: Reham Abdel-Wahab, Gauri R. Varadhachary, Priya R. Bhosale, Xuemei Wang, David R. Fogelman, Rachna T. Shroff, Michael J. Overman, Robert A. Wolff and Milind Javle
    Citation: Journal of Hematology & Oncology 2018 11:71
    Content type: Research Published on:

  50. Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment of glioblastoma (GBM). We previously found that miR-519a functions as a tumor suppressor in glioma by targeting the signal transducer an...

    Authors: Hong Li, Lei Chen, Jun-jie Li, Qiang Zhou, Annie Huang, Wei-wen Liu, Ke Wang, Liang Gao, Song-tao Qi and Yun-tao Lu
    Citation: Journal of Hematology & Oncology 2018 11:70
    Content type: Research Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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