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  1. DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic developme...

    Authors: Xiaohui Liu, Xiaoe Jia, Hao Yuan, Ke Ma, Yi Chen, Yi Jin, Min Deng, Weijun Pan, Saijuan Chen, Zhu Chen, Hugues de The, Leonard I Zon, Yi Zhou, Jun Zhou and Jun Zhu
    Citation: Journal of Hematology & Oncology 2015 8:15
    Content type: Research Published on:

  2. Expression of surface NKG2D ligand MIC on tumor cells is deemed to stimulate NK and co-stimulate CD8 T cell anti-tumor immunity. Human cancer cells however frequently adopt a proteinase-mediated shedding strat...

    Authors: Gang Xiao, Xuanjun Wang, Jun Sheng, Shengjun Lu, Xuezhong Yu and Jennifer D Wu
    Citation: Journal of Hematology & Oncology 2015 8:13
    Content type: Research Published on:

  4. Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia...

    Authors: Kejun Chen, Shuqing Lü, Hui Cheng, Gusheng Tang, Min Liu, Hong Zhou and Jianmin Wang
    Citation: Journal of Hematology & Oncology 2015 8:11
    Content type: Letter to the Editor Published on:

  5. Insulin like growth factor binding protein 7 (IGFBP7) is a secreted protein binding insulin like growth factor 1 (IGF-1), insulin, vascular endothelial growth factor A (VEGFA), and activin A. It antagonizes bo...

    Authors: Arnold Bolomsky, Dirk Hose, Martin Schreder, Anja Seckinger, Susanne Lipp, Bernard Klein, Daniel Heintel, Heinz Ludwig and Niklas Zojer
    Citation: Journal of Hematology & Oncology 2015 8:10
    Content type: Research Published on:

  6. Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene t...

    Authors: Dat Nguyen, Larry Rubinstein, Naoko Takebe, Lucio Miele, Joseph E Tomaszewski, Percy Ivy, James H Doroshow and Sherry X Yang
    Citation: Journal of Hematology & Oncology 2015 8:9
    Content type: Research Published on:

  7. Hematologic disease affects people of all ages worldwide. In the past decade, researchers have made great progress in the field of hematology. In the present study we compared the hematology research output fr...

    Authors: Lei Zhang, Xin Ye, Yi Sun, An-mei Deng and Bao-hua Qian
    Citation: Journal of Hematology & Oncology 2015 8:8
    Content type: Research Published on:

  8. Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in v...

    Authors: Yiren Xiao, Xinru Wei, Zhiwu Jiang, Xiangmeng Wang, Wei Ye, Xin Liu, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Huihui Yao, Zixia Liu, Su Cao, Pentao Liu, Bing Xu, Yangqiu Li…
    Citation: Journal of Hematology & Oncology 2015 8:7
    Content type: Letter to the Editor Published on:

  10. The prognosis of relapsed acute myeloid leukemia (AML) in elderly patients is dismal, even if the AML exhibits a good prognostic karyotype, such as inv(16)(p13.1q22). We present a 72-year-old female with AML w...

    Authors: Masahisa Arahata, Yukihiro Shimizu, Hidesaku Asakura and Shinji Nakao
    Citation: Journal of Hematology & Oncology 2015 8:5
    Content type: Letter to the Editor Published on:

  11. Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT).

    Authors: Frédéric Baron, Pierre Zachée, Johan Maertens, Tessa Kerre, Aurélie Ory, Laurence Seidel, Carlos Graux, Philippe Lewalle, Michel Van Gelder, Koen Theunissen, Evelyne Willems, Marie-Paule Emonds, Ann De Becker and Yves Beguin
    Citation: Journal of Hematology & Oncology 2015 8:4
    Content type: Research Published on:

  12. The tyrosine kinase receptor insulin-like growth factor 1 receptor (IGF-IR) contributes to the initiation and progression of many types of malignancies. We previously showed that IGF-2, which binds IGF-IR, is ...

    Authors: Jingjing Xie, Xiaoli Chen, Junke Zheng, Chunling Li, Satomi Stacy, Martin Holzenberger, Xuemei Hu and Cheng Cheng Zhang
    Citation: Journal of Hematology & Oncology 2015 8:3
    Content type: Research Published on:

  13. High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target who...

    Authors: Xiaoyun Han, Xiugui Sheng, Hannah M Jones, Amanda L Jackson, Joshua Kilgore, Jessica E Stine, Monica N Schointuch, Chunxiao Zhou and Victoria L Bae-Jump
    Citation: Journal of Hematology & Oncology 2015 8:2
    Content type: Letter to the Editor Published on:

  14. Acute leukemia is currently the major cause of death in hematological malignancies. Despite the rapid development of new therapies, minimal residual disease (MRD) continues to occur and leads to poor outcomes....

    Authors: Kaimin Hu, Yanjun Gu, Lixia Lou, Lizhen Liu, Yongxian Hu, Binsheng Wang, Yi Luo, Jimin Shi, Xiaohong Yu and He Huang
    Citation: Journal of Hematology & Oncology 2015 8:1
    Content type: Research Published on:

  15. Although, substantial experimental evidence related to diagnosis and treatment of pediatric central nervous system (CNS) neoplasms have been demonstrated, the understanding of the etiology and pathogenesis of ...

    Authors: Maria Braoudaki, George I Lambrou, Krinio Giannikou, Vasilis Milionis, Kalliopi Stefanaki, Diane K Birks, Neophytos Prodromou, Aggeliki Kolialexi, Antonis Kattamis, Chara A Spiliopoulou, Fotini Tzortzatou-Stathopoulou and Emmanouel Kanavakis
    Citation: Journal of Hematology & Oncology 2014 7:96
    Content type: Research Published on:

  16. Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns ar...

    Authors: Karolina Skvarova Kramarzova, Karel Fiser, Ester Mejstrikova, Katerina Rejlova, Marketa Zaliova, Maarten Fornerod, Harry A Drabkin, Marry M van den Heuvel-Eibrink, Jan Stary, Jan Trka and Julia Starkova
    Citation: Journal of Hematology & Oncology 2014 7:94
    Content type: Research Published on:

  17. Most patients with small cell lung cancer (SCLC) or neuroblastoma (NB) already show clinically detectable metastases at diagnosis and have an extremely poor prognosis even when treated with combined modalities...

    Authors: Debra Ehrlich, Bo Wang, Wei Lu, Peter Dowling and Ruirong Yuan
    Citation: Journal of Hematology & Oncology 2014 7:91
    Content type: Research Published on:

  18. We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units o...

    Authors: Rebekka K Schneider, Susanne Ziegler, Isabelle Leisten, Monica SV Ferreira, Anne Schumacher, Björn Rath, Dirk Fahrenkamp, Gerhard Müller-Newen, Martina Crysandt, Stefan Wilop, Edgar Jost, Steffen Koschmieder, Ruth Knüchel, Tim H Brümmendorf and Patrick Ziegler
    Citation: Journal of Hematology & Oncology 2014 7:92
    Content type: Letter to the Editor Published on:

  19. According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress i...

    Authors: Bing Li, Robert Peter Gale and Zhijian Xiao
    Citation: Journal of Hematology & Oncology 2014 7:93
    Content type: Review Published on:

  21. Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expr...

    Authors: Gregory Loewen, Janarthanan Jayawickramarajah, Ying Zhuo and Bin Shan
    Citation: Journal of Hematology & Oncology 2014 7:90
    Content type: Review Published on:

  22. The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS....

    Authors: Valeria Visconte, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Kyoichi Isono, Haruhiko Koseki, Mikkael A Sekeres, Yogen Saunthararajah, John Barnard, Daniel Lindner, Heesun J Rogers and Ramon V Tiu
    Citation: Journal of Hematology & Oncology 2014 7:89
    Content type: Research Published on:

  23. Peripheral T-cell lymphomas (PTCLs) are often aggressive tumors and resistant to conventional chemotherapy. Dysregulation of extrinsic apoptosis plays an important role on tumor cell sensitivity to chemotherap...

    Authors: Zhong Zheng, Shu Cheng, Wen Wu, Li Wang, Yan Zhao, Yang Shen, Anne Janin and Wei-Li Zhao
    Citation: Journal of Hematology & Oncology 2014 7:88
    Content type: Research Published on:

  24. Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell ...

    Authors: Xun Yuan, Hua Wu, Na Han, Hanxiao Xu, Qian Chu, Shiying Yu, Yuan Chen and Kongming Wu
    Citation: Journal of Hematology & Oncology 2014 7:87
    Content type: Review Published on:

  25. Since the discovery of circulating microRNAs (miRNAs) in body fluids, an increasing number of studies have focused on their potential as non-invasive biomarkers and as therapeutic targets or tools for many dis...

    Authors: Wen-Tao Wang and Yue-Qin Chen
    Citation: Journal of Hematology & Oncology 2014 7:86
    Content type: Review Published on:

  26. Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle and proliferation of both normal and malignant tissues. Dysregulation of this fundamental process may affect ...

    Authors: Giovanni Luca Gravina, William Senapedis, Dilara McCauley, Erkan Baloglu, Sharon Shacham and Claudio Festuccia
    Citation: Journal of Hematology & Oncology 2014 7:85
    Content type: Review Published on:

  27. While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies ...

    Authors: Minlee Kim and Frank J Slack
    Citation: Journal of Hematology & Oncology 2014 7:84
    Content type: Research highlight Published on:

  29. Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

    Authors: Santiago Schiaffino-Ortega, Carlos Balinas, Marta Cuadros and Pedro P Medina
    Citation: Journal of Hematology & Oncology 2014 7:81
    Content type: Research highlight Published on:

  30. Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous del...

    Authors: David Guenat, Samuel Quentin, Carmelo Rizzari, Catarina Lundin, Tiziana Coliva, Patrick Edery, Helen Fryssira, Laurent Bermont, Christophe Ferrand, Jean Soulier, Christophe Borg and Pierre-Simon Rohrlich
    Citation: Journal of Hematology & Oncology 2014 7:82
    Content type: Letter to the Editor Published on:

  31. Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an impor...

    Authors: Shihui Ma, Yingxu Shi, Yakun Pang, Fang Dong, Hui Cheng, Sha Hao, Jing Xu, Xiaofan Zhu, Weiping Yuan, Tao Cheng and Guoguang Zheng
    Citation: Journal of Hematology & Oncology 2014 7:71
    Content type: Research Published on:

  32. Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is...

    Authors: Ying Shao, Zhongjian Cheng, Xinyuan Li, Valeria Chernaya, Hong Wang and Xiao-feng Yang
    Citation: Journal of Hematology & Oncology 2014 7:80
    Content type: Review Published on:

  33. Recently it was reported that microRNA from the miR-17 ~ 92 family may have a key role in chronic lymphocytic leukemia (CLL). Here, we designed specific oligonucleotides to target endogenous miR-17 (antagomiR17)....

    Authors: Sara Dereani, Paolo Macor, Tiziana D’Agaro, Nelly Mezzaroba, Michele Dal-Bo, Sara Capolla, Antonella Zucchetto, Erika Tissino, Giovanni Del Poeta, Sonia Zorzet, Valter Gattei and Riccardo Bomben
    Citation: Journal of Hematology & Oncology 2014 7:79
    Content type: Letter to the Editor Published on:

  34. Renal cell carcinoma (RCC) is a complex with diverse biological characteristics and distinct molecular signature. New target therapies to molecules that drive RCC initiation and progression have achieved promi...

    Authors: Qian Chu, Na Han, Xun Yuan, Xin Nie, Hua Wu, Yu Chen, Mingzhou Guo, Shiying Yu and Kongming Wu
    Citation: Journal of Hematology & Oncology 2014 7:73
    Content type: Research Published on:

  36. The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with ...

    Authors: Yajuan Cui, Bing Li, Robert Peter Gale, Qian Jiang, Zefeng Xu, Tiejun Qin, Peihong Zhang, Yue Zhang and Zhijian Xiao
    Citation: Journal of Hematology & Oncology 2014 7:77
    Content type: Letter to the Editor Published on:

  37. The identification of fusion genes such as SYT-SSX1/SSX2, PAX3-FOXO1, TPM3/TPM4-ALK and EWS-FLI1 in human sarcomas has provided important insight into the diagnosis and targeted therapy of sarcomas. No recurrent ...

    Authors: Jilong Yang, Matti Annala, Ping Ji, Guowen Wang, Hong Zheng, David Codgell, Xiaoling Du, Zhiwei Fang, Baocun Sun, Matti Nykter, Kexin Chen and Wei Zhang
    Citation: Journal of Hematology & Oncology 2014 7:76
    Content type: Research Published on:

  38. Exportin 1 (XPO1), also called chromosome region maintenance 1 (CRM1), is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus.

    Authors: Giovanni Luca Gravina, Monica Tortoreto, Andrea Mancini, Alessandro Addis, Ernesto Di Cesare, Andrea Lenzi, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Nadia Zaffaroni and Claudio Festuccia
    Citation: Journal of Hematology & Oncology 2014 7:46
    Content type: Research Published on:

  39. De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML DNMT3A/FLT3/NPM1 ) has been suggested to represent a unique AML subset on the basis ...

    Authors: Sanam Loghavi, Zhuang Zuo, Farhad Ravandi, Hagop M Kantarjian, Carlos Bueso-Ramos, Liping Zhang, Rajesh R Singh, Keyur P Patel, L Jeffrey Medeiros, Francesco Stingo, Mark Routbort, Jorge Cortes, Rajyalakshmi Luthra and Joseph D Khoury
    Citation: Journal of Hematology & Oncology 2014 7:74
    Content type: Research Published on:

  41. Technological advancements in the molecular characterization of cancers have enabled researchers to identify an increasing number of key molecular drivers of cancer progression. These discoveries have led to m...

    Authors: Alan D Smith, Desam Roda and Timothy A Yap
    Citation: Journal of Hematology & Oncology 2014 7:70
    Content type: Review Published on:

  42. Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T ce...

    Authors: Xuebin Ji, Liping Zhang, Jun Peng and Ming Hou
    Citation: Journal of Hematology & Oncology 2014 7:72
    Content type: Review Published on:

  43. It has recently been reported that the extracts of green tea polyphenol have cancer preventive effects. In this study, we investigated the effect of the natural composition from green tea leaves Catechins on a...

    Authors: Li Zhang, Qiu-Sheng Chen, Peng-Peng Xu, Ying Qian, Ai-Hua Wang, Dan Xiao, Yan Zhao, Yan Sheng, Xiang-Qin Wen and Wei-Li Zhao
    Citation: Journal of Hematology & Oncology 2014 7:75
    Content type: Research Published on:

  44. Studying DNA methylation changes in the context of structural rearrangements and point mutations as well as gene expression changes enables the identification of genes that are important for disease onset and ...

    Authors: Hana Hájková, Markus Hsi-Yang Fritz, Cedrik Haškovec, Jiří Schwarz, Cyril Šálek, Jana Marková, Zdeněk Krejčík, Michaela Dostálová Merkerová, Arnošt Kostečka, Martin Vostrý, Ota Fuchs, Kyra Michalová, Petr Cetkovský and Vladimír Beneš
    Citation: Journal of Hematology & Oncology 2014 7:66
    Content type: Short report Published on:

  45. Head and neck squamous cell carcinoma (HNSCC) mortality rates have not shown significant reduction in decades. Platelets are being implicated in having cancer-promoting roles, an observation supported by the a...

    Authors: Saleh Rachidi, Kristin Wallace, Terry A Day, Anthony J Alberg and Zihai Li
    Citation: Journal of Hematology & Oncology 2014 7:65
    Content type: Research Published on:

  46. CCAAT/enhancer-binding protein-α (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large nu...

    Authors: James M Hughes, Beatrice Salvatori, Federico M Giorgi, Irene Bozzoni and Alessandro Fatica
    Citation: Journal of Hematology & Oncology 2014 7:69
    Content type: Letter to the Editor Published on:

  47. The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an ac...

    Authors: Yoshiaki Chinen, Natsumi Sakamoto, Hisao Nagoshi, Tomohiko Taki, Saori Maegawa, Shotaro Tatekawa, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Mio Yamamoto-Sugitani, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Junya Kuroda and Masafumi Taniwaki
    Citation: Journal of Hematology & Oncology 2014 7:68
    Content type: Letter to the Editor Published on:

  48. Non-Hodgkin lymphomas (NHLs) account for 4% of all malignancies. 5-year survival rate increased to 50% with new treatment modalities, however there is need for new effective treatment for the more aggressive, ...

    Authors: Alexandra Aronin, Shira Amsili, Tatyana B Prigozhina, Kobi Tzdaka, Roy Shen, Leonid Grinmann, Fanny Szafer, Per Edebrink, Mari-Anne Rauvola, Noam Shani and Michal Dranitzki Elhalel
    Citation: Journal of Hematology & Oncology 2014 7:64
    Content type: Research Published on:

  49. The aim of this study was to analyze the long-term survival of AML patients with CEBPA mutations.

    Authors: Friederike Pastore, Daniela Kling, Eva Hoster, Annika Dufour, Nikola P Konstandin, Stephanie Schneider, Maria C Sauerland, Wolfgang E Berdel, Thomas Buechner, Bernhard Woermann, Jan Braess, Wolfgang Hiddemann and Karsten Spiekermann
    Citation: Journal of Hematology & Oncology 2014 7:55
    Content type: Research Published on:

  50. The CD20-directed monoclonal antibody rituximab established a new era in lymphoma therapy. Since then other epitopes on the lymphoma surface have been identified as potential targets for monoclonal antibodies ...

    Authors: Tejas Suresh, Lisa X Lee, Jitesh Joshi and Stefan K Barta
    Citation: Journal of Hematology & Oncology 2014 7:58
    Content type: Review Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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