Journal of Hematology & Oncology is the official journal of the Chinese American Hematologist and Oncologist Network.
Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization
We previously reported a PI3K inhibitor S14161 which displays a promising preclinical activity against multiple myeloma (MM) and leukemia, but the chiral structure and poor solubility prevent its further appli...