Journal of Hematology & Oncology is the official journal of the Chinese American Hematologist and Oncologist Network.
Targeting mutant p53 for cancer therapy: direct and indirect strategies
TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties. ...