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  1. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the ea...

    Authors: Sun Zi-Min, Liu Hui-Lan, Geng Liang-Quan, Wang Xin-Bing, Yao Wen, Liu Xin, Ding Kai-Yang, Han Yong-Sheng, Yang Hui-Zhi, Tang Bo-lin, Tong Juan, Zhu Wei-Bo and Wang Zu-Yi

    Citation: Journal of Hematology & Oncology 2010 3:51

    Content type: Letter to the Editor

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  2. Zearalenone (ZEA) is a phytoestrogen from Fusarium species. The aims of the study was to identify mode of human leukemic cell death induced by ZEA and the mechanisms involved.

    Authors: Ratana Banjerdpongchai, Prachya Kongtawelert, Orawan Khantamat, Chantragan Srisomsap, Daranee Chokchaichamnankit, Pantipa Subhasitanont and Jisnuson Svasti

    Citation: Journal of Hematology & Oncology 2010 3:50

    Content type: Research

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  3. We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphoc...

    Authors: Séverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, Jean-Pierre Kolb and Christian Billard

    Citation: Journal of Hematology & Oncology 2010 3:49

    Content type: Letter to the Editor

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  4. We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells ...

    Authors: Shaohong Jiang, Xudong Ma, Yiqun Huang, Yunlu Xu, Ruiji Zheng and Jen-Wei Chiao

    Citation: Journal of Hematology & Oncology 2010 3:48

    Content type: Research

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  5. Recent reports indicate that microRNAs (miRNAs) play a critical role in malignancies. However, the role that miRNAs play in pancreatic cancer remains to be determined. The purpose of this study was to investig...

    Authors: Xing J Zhang, Hua Ye, Cheng W Zeng, Bo He, Hua Zhang and Yue Q Chen

    Citation: Journal of Hematology & Oncology 2010 3:46

    Content type: Research

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  6. Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenes...

    Authors: Patrick B Johnston, RuiRong Yuan, Franco Cavalli and Thomas E Witzig

    Citation: Journal of Hematology & Oncology 2010 3:45

    Content type: Review

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  7. In a human T-cell acute lymphoblastic leukemia (T-ALL) cell line (Molt-4), siRNA-mediated suppression of BCL11B expression was shown to inhibit proliferation and induce apoptosis, functions which may be related t...

    Authors: Xin Huang, Shaohua Chen, Qi Shen, Lijian Yang, Bo Li, Liye Zhong, Suxia Geng, Xin Du and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2010 3:44

    Content type: Research

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  8. Hepatocellular carcinoma (HCC) still is a big burden for China. In recent years, the third-generation platinum compounds have been proposed as potential active agents for HCC. However, more experimental and cl...

    Authors: Qiong Wu, Shu-Kui Qin, Feng-Meng Teng, Chang-Jie Chen and Rui Wang

    Citation: Journal of Hematology & Oncology 2010 3:43

    Content type: Research

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  9. Breast cancer is a heterogeneous disease composed of different subtypes, characterized by their different clinicopathological characteristics, prognoses and responses to treatment. In the past decade, signific...

    Authors: Rafael Santana-Davila and Edith A Perez

    Citation: Journal of Hematology & Oncology 2010 3:42

    Content type: Review

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  10. Mutations in the nucleophosmin (NPM1) gene have been solely associated with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 mutations in childhood AML, their relation to clinical and cy...

    Authors: Maria Braoudaki, Chrissa Papathanassiou, Katerina Katsibardi, Natalia Tourkadoni, Kalliopi Karamolegou and Fotini Tzortzatou-Stathopoulou

    Citation: Journal of Hematology & Oncology 2010 3:41

    Content type: Research

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  11. Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER para...

    Authors: Saad Z Usmani, Robert D Bona, Gabriela Chiosis and Zihai Li

    Citation: Journal of Hematology & Oncology 2010 3:40

    Content type: Research

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  12. To report clinical efficacy and toxicity of fractionated CyberKnife radiosurgery for the treatment of hilar lung tumors.

    Authors: Keith Unger, Andrew Ju, Eric Oermann, Simeng Suy, Xia Yu, Saloomeh Vahdat, Deepa Subramaniam, K William Harter, Sean P Collins, Anatoly Dritschilo, Eric Anderson and Brian T Collins

    Citation: Journal of Hematology & Oncology 2010 3:39

    Content type: Short report

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  13. Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences...

    Authors: Antonio Sacco, Ghayas C Issa, Yong Zhang, Yang Liu, Patricia Maiso, Irene M Ghobrial and Aldo M Roccaro

    Citation: Journal of Hematology & Oncology 2010 3:38

    Content type: Review

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  14. MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features rela...

    Authors: Anuradha Budhu, Junfang Ji and Xin W Wang

    Citation: Journal of Hematology & Oncology 2010 3:37

    Content type: Review

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  15. Optimal conditioning therapy for hematopoietic cell transplantation (HCT) in acute myelogenous leukemia (AML) remains undefined. We retrospectively compared outcomes of a consecutive series of 51 AML patients ...

    Authors: Joseph Pidala, Jongphil Kim, Claudio Anasetti, Mohamed A Kharfan-Dabaja, Taiga Nishihori, Teresa Field, Janelle Perkins, Lia Perez and Hugo F Fernandez

    Citation: Journal of Hematology & Oncology 2010 3:36

    Content type: Research

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  16. Mantle cell lymphoma is a lymphoid entity characterized by adenopathy, blood and bone marrow involment which only recurrent mucosal localisation is the lymphomatoid polyposis. Few other mucosal infiltrations h...

    Authors: Jean-Christophe Ianotto, Adrian Tempescul, Jean-Richard Eveillard, Norbert André, Frederic Morel, Isabelle Quintin-Roué and Christian Berthou

    Citation: Journal of Hematology & Oncology 2010 3:34

    Content type: Letter to the Editor

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  17. Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the patho...

    Authors: Xueling GE and Xin Wang

    Citation: Journal of Hematology & Oncology 2010 3:33

    Content type: Review

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  18. We describe a case of multiple myeloma (MM) and secondary plasma cell leukemia (PCL) secreting IgE-kappa immunoglobulin. To our knowledge, only 2 cases of IgE-producing secondary PCL have been reported in the ...

    Authors: Giampaolo Talamo, William Castellani and Nathan G Dolloff

    Citation: Journal of Hematology & Oncology 2010 3:32

    Content type: Case report

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  19. We report a 49-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with trastuzumab-containing regimen. He underwent esoph...

    Authors: Jun Wang, George W Saukel, Carlos A Garberoglio, Wichit Srikureja and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2010 3:31

    Content type: Case report

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  20. Mantle cell lymphoma (MCL) is a rare and aggressive type of B-cell non-Hodgkin's lymphoma. Patients become progressively refractory to conventional chemotherapy, and their prognosis is poor. However, a 38% rem...

    Authors: Li Wang, Wen-Yu Shi, Zhi-Yuan Wu, Mariana Varna, Ai-Hua Wang, Li Zhou, Li Chen, Zhi-Xiang Shen, He Lu, Wei-Li Zhao and Anne Janin

    Citation: Journal of Hematology & Oncology 2010 3:30

    Content type: Case report

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  21. The Gγ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about Gγ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This stud...

    Authors: Rong Rong Liu, Ming Yue Wang and Yong Rong Lai

    Citation: Journal of Hematology & Oncology 2010 3:29

    Content type: Letter to the Editor

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  22. Acute promyelocytic leukemia (APL) is a blood cancer that affects people of all ages and strikes about 1,500 patients in the United States each year. The standard treatment of APL has been based on the combine...

    Authors: Clement Yedjou, Paul Tchounwou, John Jenkins and Robert McMurray

    Citation: Journal of Hematology & Oncology 2010 3:28

    Content type: Research

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  23. In newly diagnosed patients with Hodgkin lymphoma (HL) the effect of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD)-related neutropenia on chemotherapy delivery is poorly documented. The aim of thi...

    Authors: Matthias Schwenkglenks, Ruth Pettengell, Thomas D Szucs, Eva Culakova and Gary H Lyman

    Citation: Journal of Hematology & Oncology 2010 3:27

    Content type: Short report

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  24. Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplast...

    Authors: Clara Hwang and Elisabeth I Heath

    Citation: Journal of Hematology & Oncology 2010 3:26

    Content type: Review

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  25. The ring chromosome is a circular, structural abnormality composed of either multiple chromosomes or a single chromosome with loss of genetic material at one or both ends. This chromosomal rearrangement is oft...

    Authors: Shanthi Sivendran, Stephen Gruenstein, Adriana K Malone and Vesna Najfeld

    Citation: Journal of Hematology & Oncology 2010 3:25

    Content type: Case report

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  26. We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subseq...

    Authors: Marnelli A Bautista-Quach, Yu-Min Liao and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2010 3:24

    Content type: Case report

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  27. Management of localized primary gastric B lymphoma (PGL) remains controversial. The aim of this study is to compare two treatments: chemotherapy alone and surgery plus chemotherapy.

    Authors: Yassir Sbitti, Nabil Ismaili, Youssef Bensouda, Habiba Kadiri, Mohammed Ichou and Hassan Errihani

    Citation: Journal of Hematology & Oncology 2010 3:23

    Content type: Short report

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  28. With conventional radiation technique alone, it is difficult to deliver radical treatment (≥ 60 Gy) to gliomas that are close to critical structures without incurring the risk of late radiation induced complic...

    Authors: Eric Oermann, Brian T Collins, Kelly T Erickson, Xia Yu, Sue Lei, Simeng Suy, Heather N Hanscom, Joy Kim, Hyeon U Park, Andrew Eldabh, Christopher Kalhorn, Kevin McGrail, Deepa Subramaniam, Walter C Jean and Sean P Collins

    Citation: Journal of Hematology & Oncology 2010 3:22

    Content type: Research

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  29. There has been little literature about leukemia epidemiology in Nanjing in recent years. We aimed to explore the incidence rate, gender and age distribution of leukemia in Nanjing using the leukemia database o...

    Authors: Bao-An Chen, Zhi-Hu Huang, Xiao-Ping Zhang, Jian Ou-Yang, Jian-Yong Li, Yong-Ping Zhai, Xue-Mei Sun, Yan-Li Xu, Qin Lu, Jian-Min Wang, Dong Li, Hui Liao, Zhi-Xiang Shen, Yan-Yan Wang, Xiao-Jing Yu, Hui Ye…

    Citation: Journal of Hematology & Oncology 2010 3:21

    Content type: Letter to the Editor

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  30. A 24-year-old female patient was diagnosed with classic Hodgkin's lymphoma in clinical stage II, and combination chemotherapy followed by radiotherapy was initiated. During the following 5 years, the disease p...

    Authors: Inga Mandac and Slobodanka Ostojic Kolonic

    Citation: Journal of Hematology & Oncology 2010 3:20

    Content type: Letter to the Editor

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  31. We have reviewed the pivotal presentations in non-small cell lung cancer (NSCLC) from the 2009 annual meeting of the American Society of Clinical Oncology. We have discussed the scientific data, the impact on ...

    Authors: Hamid R Mirshahidi and Chung T Hsueh

    Citation: Journal of Hematology & Oncology 2010 3:18

    Content type: Review

    Published on:

  32. Treatment options for patients with lower risk non-del(5q) myelodysplastic syndromes (MDS) who fail erythroid stimulating agents are restricted to one of the hypomethylating drugs with an expected response rat...

    Authors: Fahd Quddus, Jessica Clima, Helen Seedham, Ghulam Sajjad, Naomi Galili and Azra Raza

    Citation: Journal of Hematology & Oncology 2010 3:16

    Content type: Case report

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  33. CD7 is a negative prognostic marker in myeloid malignancies. In acute myeloid leukemia (AML), an inverse correlation exists between expression of wild-type CEBPA and CD7. Aim of this study was to find out whether...

    Authors: Sonja Röhrs, Michaela Scherr, Julia Romani, Margarete Zaborski, Hans G Drexler and Hilmar Quentmeier

    Citation: Journal of Hematology & Oncology 2010 3:15

    Content type: Research

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  34. The development of Philadelphia chromosome (Ph) negative acute leukemia/myelodysplastic syndrome (MDS) in patients with Ph-positive chronic myeloid leukemia (CML) is very rare. The features of restrictive usag...

    Authors: Liang Wang, Kanger Zhu, Xianfeng Zha, Shaohua Chen, Lijian Yang, Si Chen and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2010 3:14

    Content type: Research

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  35. Multiple myeloma (MM) is the second most common hematological malignancy in adults. It is characterized by clonal proliferation of terminally differentiated B lymphocytes and over-production of monoclonal immu...

    Authors: Johann Micallef, Moyez Dharsee, Jian Chen, Suzanne Ackloo, Ken Evans, Luqui Qiu and Hong Chang

    Citation: Journal of Hematology & Oncology 2010 3:13

    Content type: Review

    Published on:

  36. Oxaliplatin is a platinum compound used in the treatment of gastrointestinal malignancies, including colorectal cancer. The incidence of hypersensitivity reaction in patients receiving oxaliplatin is approxima...

    Authors: Marnelli A Bautista, W Tait Stevens, Chien-Shing Chen, Brian R Curtis, Richard H Aster and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2010 3:12

    Content type: Case report

    Published on:

  37. We have reviewed the pivotal presentations related to gastrointestinal malignancies from 2009 annual meeting of the American Society of Clinical Oncology with the theme of "personalizing cancer care". We have ...

    Authors: Milind Javle and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2010 3:11

    Content type: Review

    Published on:

  38. The ribonucleotide reductase M1 (RRM1) gene encodes the regulatory subunit of ribonucleotide reductase, the molecular target of gemcitabine. The overexpression of RRM1 mRNA in tumor tissues is reported to be a...

    Authors: Song Dong, Ai-Lin Guo, Zhi-Hong Chen, Zhen Wang, Xu-Chao Zhang, Ying Huang, Zhi Xie, Hong-Hong Yan, Hua Cheng and Yi-Long Wu

    Citation: Journal of Hematology & Oncology 2010 3:10

    Content type: Research

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  39. Canfosfamide is a novel glutathione analog activated by glutathione S-transferase P1-1. This study evaluated the safety and efficacy of canfosfamide in combination with pegylated liposomal doxorubicin (PLD) in...

    Authors: John J Kavanagh, Charles F Levenback, Pedro T Ramirez, Judith L Wolf, Carla L Moore, Marsha R Jones, Lisa Meng, Gail L Brown and Robert C Bast Jr

    Citation: Journal of Hematology & Oncology 2010 3:9

    Content type: Research

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  40. Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an imp...

    Authors: Bei Liu, John Nash, Carolyn Runowicz, Helen Swede, Richard Stevens and Zihai Li

    Citation: Journal of Hematology & Oncology 2010 3:7

    Content type: Review

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  41. To report serial 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) tumor response following CyberKnife radiosurgery for stage IA non-small cell lung cancer (NSCLC).

    Authors: Saloomeh Vahdat, Eric K Oermann, Sean P Collins, Xia Yu, Malak Abedalthagafi, Pedro DeBrito, Simeng Suy, Shadi Yousefi, Constanza J Gutierrez, Thomas Chang, Filip Banovac, Eric D Anderson, Giuseppe Esposito and Brian T Collins

    Citation: Journal of Hematology & Oncology 2010 3:6

    Content type: Research

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  42. Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and activities of transcriptional factors involved in both cancer initiation and progression through alteration of either DNA or t...

    Authors: Jiahuai Tan, Shundong Cang, Yuehua Ma, Richard L Petrillo and Delong Liu

    Citation: Journal of Hematology & Oncology 2010 3:5

    Content type: Review

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  43. No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom...

    Authors: Yu Ri Seo, Se Hyung Kim, Hyun Jung Kim, Chan Kyu Kim, Seong Kyu Park, Eun Suk Koh and Dae Sik Hong

    Citation: Journal of Hematology & Oncology 2010 3:4

    Content type: Case report

    Published on:

  44. Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually, the sign of Leser-Trélat is associated with adenoca...

    Authors: Giovanni Ponti, Gabriele Luppi, Lorena Losi, Alberto Giannetti and Stefania Seidenari

    Citation: Journal of Hematology & Oncology 2010 3:2

    Content type: Case report

    Published on:

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