Journal of Hematology & Oncology is the official journal of the Chinese American Hematologist and Oncologist Network.
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP
We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degr...