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  1. Upon inflammation, myeloid cell generation in the bone marrow (BM) is broadly enhanced by the action of induced cytokines which are produced locally and at multiple sites throughout the body.

    Authors: Anne Schumacher, Bernd Denecke, Till Braunschweig, Jasmin Stahlschmidt, Susanne Ziegler, Lars-Ove Brandenburg, Matthias B. Stope, Antons Martincuks, Michael Vogt, Dieter Görtz, Annalisa Camporeale, Valeria Poli, Gerhard Müller-Newen, Tim H. Brümmendorf and Patrick Ziegler
    Citation: Journal of Hematology & Oncology 2015 8:64
    Content type: Research Published on:

  2. Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin’s lymphoma. Despite initial intense chemotherapy, up to 50 % of cases of MCL relapse often in a chemoresistant form. We hypothesize...

    Authors: Rohit Mathur, Lalit Sehgal, Frank K. Braun, Zuzana Berkova, Jorge Romaguerra, Michael Wang, M. Alma Rodriguez, Luis Fayad, Sattva S. Neelapu and Felipe Samaniego
    Citation: Journal of Hematology & Oncology 2015 8:63
    Content type: Research Article Published on:

  3. Interaction of integrin β3 with c-Src plays critical roles in cellular signaling which is heavily implicated in platelet adhesion and aggregation, as well as in tumor cell proliferation and metastasis or in os...

    Authors: Jiansong Huang, Xiaofeng Shi, Wenda Xi, Ping Liu, Zhangbiao Long and Xiaodong Xi
    Citation: Journal of Hematology & Oncology 2015 8:62
    Content type: Research Article Published on:

  4. Methotrexate (MTX) eradicates leukemic cells by disrupting de novo nucleotide biosynthesis and DNA replication, resulting in cell death. Since its introduction in 1947, MTX-containing chemotherapeutic regimens...

    Authors: Anna Wojtuszkiewicz, Godefridus J. Peters, Nicole L. van Woerden, Boas Dubbelman, Gabriele Escherich, Kjeld Schmiegelow, Edwin Sonneveld, Rob Pieters, Peter M. van de Ven, Gerrit Jansen, Yehuda G. Assaraf, Gertjan J. L. Kaspers and Jacqueline Cloos
    Citation: Journal of Hematology & Oncology 2015 8:61
    Content type: Research Article Published on:

  5. Tyrosine kinase inhibitors (TKIs) targeting signaling molecules downstream B cell receptor (BCR) are powerfully spreading in the therapeutic landscape of B cell lymphoproliferative disease, due to a manageable...

    Authors: Rossana Maffei, Stefania Fiorcari, Silvia Martinelli, Leonardo Potenza, Mario Luppi and Roberto Marasca
    Citation: Journal of Hematology & Oncology 2015 8:60
    Content type: Review Published on:

  6. The mouse is an organism that is widely used as a mammalian model for studying human physiology or disease, and the development of immunodeficient mice has provided a valuable tool for basic and applied human ...

    Authors: Wei Ye, Zhiwu Jiang, Guan-Xiong Li, Yiren Xiao, Simiao Lin, Yunxin Lai, Suna Wang, Baiheng Li, Bei Jia, Yin Li, Zhi-liang Huang, Jin Li, Fenglan Feng, Shuhua Li, Huihui Yao, Zixia Liu…
    Citation: Journal of Hematology & Oncology 2015 8:59
    Content type: Research Published on:

  7. Biliary cancers are highly aggressive tumors that are often diagnosed an advanced disease stage and have a poor outcome with systemic therapy. Recent efforts towards molecular characterization have identified ...

    Authors: Milind Javle, Chaitanya Churi, HyunSeon C. Kang, Rachna Shroff, Filip Janku, Rakesh Surapaneni, Mingxin Zuo, Christian Barrera, Humaid Alshamsi, Sunil Krishnan, Lopa Mishra, Robert A. Wolff, Ahmed O. Kaseb, Melanie B. Thomas and Abby B. Siegel
    Citation: Journal of Hematology & Oncology 2015 8:58
    Content type: Research Article Published on:

  8. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, especially in China. And the mechanism of its progression remains poorly understood. Growing evidence indicates that long no...

    Authors: Ming-de Huang, Wen-ming Chen, Fu-zhen Qi, Rui Xia, Ming Sun, Tong-peng Xu, Li Yin, Er-bao Zhang, Wei De and Yong-qian Shu
    Citation: Journal of Hematology & Oncology 2015 8:57
    Content type: Research Article Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:143

  9. microRNAs (miRNAs) have been reported to modulate macrophage colony-stimulating factor (M-CSF) and macrophages. The aim of this study was to find whether miR-26a can suppress M-CSF expression and the recruitme...

    Authors: Zong-Tao Chai, Xiao-Dong Zhu, Jian-Yang Ao, Wen-Quan Wang, Dong-Mei Gao, Jian Kong, Ning Zhang, Yuan-Yuan Zhang, Bo-Gen Ye, De-Ning Ma, Hao Cai and Hui-Chuan Sun
    Citation: Journal of Hematology & Oncology 2015 8:56
    Content type: Research Article Published on:

  10. Congenital sideroblastic anemias (CSAs) comprise a group of heterogenous genetic diseases that are caused by the mutation of various genes involved in heme biosynthesis, iron-sulfur cluster biogenesis, or mito...

    Authors: Wenbin An, Jingliao Zhang, Lixian Chang, Yingchi Zhang, Yang Wan, Yuanyuan Ren, Deyun Niu, Jian Wu, Xiaofan Zhu and Ye Guo
    Citation: Journal of Hematology & Oncology 2015 8:55
    Content type: Short Report Published on:

  11. Neoadjuvant erlotinib and customized adjuvant therapy are appealing but controversial. The purpose of this study was to evaluate the role of biomarker-guided neoadjuvant treatment strategy in patients with III...

    Authors: Wenzhao Zhong, Xuening Yang, Honghong Yan, Xuchao Zhang, Jian Su, Zhihong Chen, Riqiang Liao, Qiang Nie, Song Dong, Qing Zhou, Jinji Yang, Haiyan Tu and Yi-Long Wu
    Citation: Journal of Hematology & Oncology 2015 8:54
    Content type: Short Report Published on:

  12. Male breast cancer is a rare malignancy. Despite the lack of prospectively generated data from trials in either the adjuvant or metastatic setting, patients are commonly treated with hormone therapies. Much co...

    Authors: Luigi Di Lauro, Laura Pizzuti, Maddalena Barba, Domenico Sergi, Isabella Sperduti, Marcella Mottolese, Carla Azzurra Amoreo, Franca Belli, Patrizia Vici, Valerie Speirs, Daniele Santini, Ruggero De Maria and Marcello Maugeri-Saccà
    Citation: Journal of Hematology & Oncology 2015 8:53
    Content type: Research Article Published on:

  13. The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy o...

    Authors: Stefano Kim, Frederic Fiteni, Sophie Paget-Bailly, François Ghiringhelli, Zaher Lakkis, Marine Jary, Francine Fein, Franck Bonnetain, Christophe Mariette and Christophe Borg
    Citation: Journal of Hematology & Oncology 2015 8:52
    Content type: Letter to the Editor Published on:

  14. Prostate cancer and chronic lymphocytic leukemia (CLL) are relatively common malignancies associated with advanced age. Although immunotherapy-based strategies are used to treat both, currently, there is no ov...

    Authors: Heather H. Cheng, Colleen Soleau and Evan Y. Yu
    Citation: Journal of Hematology & Oncology 2015 8:51
    Content type: Case report Published on:

  15. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, especially in China. And the mechanism of its progression remains poorly understood. Growing evidence indicates that long no...

    Authors: Ming-de Huang, Wen-ming Chen, Fu-zhen Qi, Rui Xia, Ming Sun, Tong-peng Xu, Li Yin, Er-bao Zhang, Wei De and Yong-qian Shu
    Citation: Journal of Hematology & Oncology 2015 8:50
    Content type: Research article Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:143

  16. The Glasgow Prognostic Score (GPS) measures inflammation and proves its prognostic value in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL) which is commonly combined with inflammatory les...

    Authors: Seok Jin Kim, Kyung Ju Ryu, Mineui Hong, Young Hyeh Ko and Won Seog Kim
    Citation: Journal of Hematology & Oncology 2015 8:49
    Content type: Rapid Communication Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2015 8:112

  17. Minimal residual disease detection in the bone marrow is usually performed in patients with acute myeloid leukemia undergoing one course of induction chemotherapy. To optimize the chemotherapy strategies, more...

    Authors: Cong Yu, Qing-lei Kong, Yun-xiang Zhang, Xiang-qin Weng, Jing Wu, Yan Sheng, Chun-lei Jiang, Yong-mei Zhu, Qi Cao, Shu-min Xiong, Jun-min Li, Xiao-dong Xi, Sai-juan Chen and Bing Chen
    Citation: Journal of Hematology & Oncology 2015 8:48
    Content type: Research article Published on:

  18. Eukaryotic cell membrane dynamics change in curvature during physiological and pathological processes. In the past ten years, a novel protein family, Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain protei...

    Authors: Suxuan Liu, Xinyu Xiong, Xianxian Zhao, Xiaofeng Yang and Hong Wang
    Citation: Journal of Hematology & Oncology 2015 8:47
    Content type: Review Published on:

  19. The therapeutic efficacy of arsenic trioxide (As2O3) in acute myeloid leukemia (AML) is modest, which is partly related to its limited intracellular uptake into the leukemic cells. As2O3 enters cells via the tran...

    Authors: David Chau, Karen Ng, Thomas Sau-Yan Chan, Yuen-Yee Cheng, Bonnie Fong, Sidney Tam, Yok-Lam Kwong and Eric Tse
    Citation: Journal of Hematology & Oncology 2015 8:46
    Content type: Research article Published on:

  20. TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t-MN versus de novo disease...

    Authors: Chi Young Ok, Keyur P Patel, Guillermo Garcia-Manero, Mark J Routbort, Jie Peng, Guilin Tang, Maitrayee Goswami, Ken H Young, Rajesh Singh, L Jeffrey Medeiros, Hagop M Kantarjian, Rajyalakshmi Luthra and Sa A Wang
    Citation: Journal of Hematology & Oncology 2015 8:45
    Content type: Research article Published on:

  22. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are approved for patients with recurrent non-small cell lung cancer (NSCLC). However, the efficacy of EGFR-TKIs in NSCLC therapy is limit...

    Authors: Siyuan Dong, Xiaohan Qu, Wenya Li, Xinwen Zhong, Peiwen Li, Shize Yang, Xitao Chen, Mingrui Shao and Lin Zhang
    Citation: Journal of Hematology & Oncology 2015 8:43
    Content type: Research Published on:

  23. Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a...

    Authors: Kristina Karrman, Anders Castor, Mikael Behrendtz, Erik Forestier, Linda Olsson, Mats Ehinger, Andrea Biloglav, Thoas Fioretos, Kajsa Paulsson and Bertil Johansson
    Citation: Journal of Hematology & Oncology 2015 8:42
    Content type: Research Published on:

  24. p53 plays important roles in regulating the metabolic reprogramming of cancer, such as aerobic glycolysis. Oroxylin A is a natural active flavonoid with strong anticancer effects both in vitro and in vivo.

    Authors: Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu and Libin Wei
    Citation: Journal of Hematology & Oncology 2015 8:41
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2019 12:143

  25. Deregulated expression of heat shock proteins (HSPs) encoding genes is frequent in multiple myeloma. HSPs, which are molecular chaperones involved in protein homeostasis pathways, have emerged recently as prom...

    Authors: Sophie Bustany, Julie Cahu, Géraldine Descamps, Catherine Pellat-Deceunynck and Brigitte Sola
    Citation: Journal of Hematology & Oncology 2015 8:40
    Content type: Letter to the Editor Published on:

  26. Novel-targeted therapies are in rapid development for the treatment of acute lymphoblastic leukemia (ALL) to overcome resistance and decrease toxicity. Survivin, a member of the inhibitor of apoptosis gene fam...

    Authors: Bill H Chang, Kara Johnson, Dorian LaTocha, Joelle S J Rowley, Jade Bryant, Russell Burke, Rebecca L Smith, Marc Loriaux, Markus Müschen, Charles Mullighan, Brian J Druker and Jeffrey W Tyner
    Citation: Journal of Hematology & Oncology 2015 8:39
    Content type: Research Published on:

  27. PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding RNAs present throughout the animal kingdom. They form complexes with several members of the PIWI clade of Argonaute prote...

    Authors: Miguel Moyano and Giovanni Stefani
    Citation: Journal of Hematology & Oncology 2015 8:38
    Content type: Review Published on:

  28. Thrombocytopenia is a significant problem in patients with relapsed or refractory multiple myeloma, precipitating a need for supportive platelet transfusions and necessitating decreases in delivered doses of c...

    Authors: Jee-Yeong Jeong, Michelle S Levine, Nirmalee Abayasekara, Nancy Berliner, Jacob Laubach and Gary J Vanasse
    Citation: Journal of Hematology & Oncology 2015 8:37
    Content type: Research Published on:

  29. NK cells expressing TIM-3 show a marked increase in IFNγ production in response to acute myeloid leukemia (AML) blast cells that endogenously express Gal-9. Herein, we demonstrate that NK cell-mediated product...

    Authors: Valentina Folgiero, Loredana Cifaldi, Giuseppina Li Pira, Bianca Maria Goffredo, Luciana Vinti and Franco Locatelli
    Citation: Journal of Hematology & Oncology 2015 8:36
    Content type: Letter to the Editor Published on:

  30. Mantle cell lymphoma (MCL) is a distinct clinical pathologic subtype of B cell non-Hodgkin’s lymphoma often associated with poor prognosis. New therapeutic approaches based on boosting anti-tumor immunity are ...

    Authors: Jingtao Chen, Gerard Zurawski, Sandy Zurawski, Zhiqing Wang, Keiko Akagawa, Sangkon Oh, Ueno Hideki, Joseph Fay, Jacques Banchereau, Wenru Song and A Karolina Palucka
    Citation: Journal of Hematology & Oncology 2015 8:35
    Content type: Research Published on:

  31. We reported that knockdown of PPP2R5C by siRNA led to proliferation inhibition and apoptosis induction in K562 cells. In this study, we further characterized the gene expression profiles after PPP2R5C suppression...

    Authors: Sichu Liu, Qi Shen, Yu Chen, Chengwu Zeng, Changshu Cao, Lijian Yang, Shaohua Chen, Xiuli Wu, Bo Li and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2015 8:34
    Content type: Letter to the Editor Published on:

  32. As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between...

    Authors: Ya-Feng Li, Li-Na Ren, Geng Guo, Lee Anne Cannella, Valeria Chernaya, Sonia Samuel, Su-Xuan Liu, Hong Wang and Xiao-Feng Yang
    Citation: Journal of Hematology & Oncology 2015 8:33
    Content type: Review Published on:

  33. Progression of chronic myelogenous leukemia (CML) is frequently accompanied by cytogenetic evolution, commonly unbalanced chromosomal changes, such as an extra copy of Philadelphia chromosome (Ph), +8, and i(1...

    Authors: Wei Wang, Guilin Tang, Jorge E Cortes, Hui Liu, Di Ai, C Cameron Yin, Shaoying Li, Joseph D Khoury, Carlos Bueso-Ramos, L Jeffrey Medeiros and Shimin Hu
    Citation: Journal of Hematology & Oncology 2015 8:32
    Content type: Research Published on:

  36. Zebrafish is an established model for the study of vertebrate development, and is especially amenable for investigating hematopoiesis, where there is strong conservation of key lineages, genes, and development...

    Authors: Parisa Rasighaemi, Faiza Basheer, Clifford Liongue and Alister C Ward
    Citation: Journal of Hematology & Oncology 2015 8:29
    Content type: Review Published on:

  37. The transcription factor Ecotropic Virus Integration site 1 (EVI1) regulates cellular proliferation, differentiation, and apoptosis, and its overexpression contributes to an aggressive course of disease in mye...

    Authors: Gerwin Heller, Anna Rommer, Katarina Steinleitner, Julia Etzler, Hubert Hackl, Petra Heffeter, Erwin Tomasich, Martin Filipits, Birgit Steinmetz, Thais Topakian, Simone Klingenbrunner, Barbara Ziegler, Andreas Spittler, Sabine Zöchbauer-Müller, Walter Berger and Rotraud Wieser
    Citation: Journal of Hematology & Oncology 2015 8:28
    Content type: Research Published on:

  38. Journal of Hematology & Oncology is pleased to see the exponential growth in the number of publications from China, especially in hematology and oncology. This editorial calls for putting more we...

    Authors: Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan and Zihai Li
    Citation: Journal of Hematology & Oncology 2015 8:27
    Content type: Editorial Published on:

  39. Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine significantly in...

    Authors: He Wang, Shu Yang, Hong Zhou, Mingna Sun, Lingran Du, Minyan Wei, Meixia Luo, Jingzhu Huang, Hongzhu Deng, Yinghong Feng, Jun Huang and Yi Zhou
    Citation: Journal of Hematology & Oncology 2015 8:26
    Content type: Research Published on:

  40. Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. Herein, we report a potential leukocyte differe...

    Authors: Min Xie, Ting Li, Ning Li, Jinlan Li, Qiumei Yao, Wenling Han and Guorui Ruan
    Citation: Journal of Hematology & Oncology 2015 8:25
    Content type: Letter to the Editor Published on:

  41. Trogocytosis is the transfer of plasma membrane fragments and the molecules they contain between one donor and one acceptor/acquirer cell. Through trogocytosis, acceptor cells temporarily display and use cell-...

    Authors: Joel LeMaoult, Julien Caumartin, Marina Daouya, Magdalena Switala, Vera Rebmann, Bertrand Arnulf and Edgardo D Carosella
    Citation: Journal of Hematology & Oncology 2015 8:24
    Content type: Research Published on:

  42. Oct4 and Nanog are key regulatory genes that maintain the pluripotency and self-renewal properties of embryonic stem cells. We previously reported that the two stemness markers were tightly associated with can...

    Authors: Xin Yin, Bo-Heng Zhang, Su-Su Zheng, Dong-Mei Gao, Shuang-Jian Qiu, Wei-Zhong Wu and Zheng-Gang Ren
    Citation: Journal of Hematology & Oncology 2015 8:23
    Content type: Research Published on:

  43. During tumor formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumor cells. Expression of key glycolytic enzyme alpha-enolase (ENO1) is controversial and its modula...

    Authors: Qiao-Fen Fu, Yan Liu, Yue Fan, Sheng-Ni Hua, Hong-Ying Qu, Su-Wei Dong, Rui-Lei Li, Meng-Yang Zhao, Yan Zhen, Xiao-Li Yu, Yi-Yu Chen, Rong-Cheng Luo, Rong Li, Li-Bo Li, Xiao-Jie Deng, Wei-Yi Fang…
    Citation: Journal of Hematology & Oncology 2015 8:22
    Content type: Research Published on:

  44. Conventional chemotherapy and radiotherapy for the treatment of lymphoma have notable drawbacks, and passive immunotherapy using a monoclonal antibody is restricted to CD20-positive B cell lymphoma. Therefore,...

    Authors: Jiang Zhu, Shiping He, Jie Du, Zhulin Wang, Wang Li, Xianxiong Chen, Wenqi Jiang, Duo Zheng and Guangyi Jin
    Citation: Journal of Hematology & Oncology 2015 8:21
    Content type: Research Published on:

  45. RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles. Noticeably, the RIP140 gene has be...

    Authors: Marion Lapierre, Audrey Castet-Nicolas, Delphine Gitenay, Stéphan Jalaguier, Catherine Teyssier, Caroline Bret, Guillaume Cartron, Jérôme Moreaux and Vincent Cavaillès
    Citation: Journal of Hematology & Oncology 2015 8:20
    Content type: Review Published on:

  47. Leukemic stem cells (LSCs) are frequently seen as a cause of treatment failure and relapse in patients with acute myeloid leukemia (AML). Thus, successful new therapeutic strategies for the treatment of AML sh...

    Authors: Dongmei Fan, Zhenzhen Li, Xiaolong Zhang, Yuqi Yang, Xiangfei Yuan, Xiuli Zhang, Ming Yang, Yizhi Zhang and Dongsheng Xiong
    Citation: Journal of Hematology & Oncology 2015 8:18
    Content type: Research Published on:

  48. Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. ALK-1 was initially found in anaplastic large cell lymphoma (ALCL). ALK mutations have also been implicated in t...

    Authors: Chaitanya Iragavarapu, Milaim Mustafa, Akintunde Akinleye, Muhammad Furqan, Varun Mittal, Shundong Cang and Delong Liu
    Citation: Journal of Hematology & Oncology 2015 8:17
    Content type: Review Published on:

  49. Since their description and identification in leukemias and solid tumors, cancer stem cells (CSC) have been the subject of intensive research in translational oncology. Indeed, recent advances have led to the ...

    Authors: Axel Schulenburg, Katharina Blatt, Sabine Cerny-Reiterer, Irina Sadovnik, Harald Herrmann, Brigitte Marian, Thomas W Grunt, Christoph C Zielinski and Peter Valent
    Citation: Journal of Hematology & Oncology 2015 8:16
    Content type: Review Published on:

  50. Anticancer treatments aiming at killing malignant cells have been applied for decades but have been unsuccessful at curing the disease. The modern concept of tumor microenvironment, especially angiogenesis, su...

    Authors: Li Zhang, C Alexander Valencia, Biao Dong, Meng Chen, Pu-Jun Guan and Ling Pan
    Citation: Journal of Hematology & Oncology 2015 8:14
    Content type: Review Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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