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  1. Bladder cancer occurs in the majority of cases in males. It represents the seventh most common cancer and the ninth most common cause of cancer deaths for men. Transitional cell carcinoma is the most predomina...

    Authors: Nabil Ismaili, Mounia Amzerin and Aude Flechon

    Citation: Journal of Hematology & Oncology 2011 4:35

    Content type: Review

    Published on:

  2. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at...

    Authors: Yu Ri Kim, Jin Seok Kim, Soo Jeong Kim, Hyun Ae Jung, Seok Jin Kim, Won Seog Kim, Hye Won Lee, Hyeon Seok Eom, Seong Hyun Jeong, Joon Seong Park, June-Won Cheong and Yoo Hong Min

    Citation: Journal of Hematology & Oncology 2011 4:34

    Content type: Research

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  3. The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expres...

    Authors: Yanyan Liu, Qingxin Xia, Yanzhao Jia, Hongqiang Guo, Bing Wei, Yawei Hua and Shujun Yang

    Citation: Journal of Hematology & Oncology 2011 4:33

    Content type: Letter to the Editor

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  4. Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilo...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka and Kazuma Ohyashiki

    Citation: Journal of Hematology & Oncology 2011 4:32

    Content type: Letter to the Editor

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  5. Pancreatic neuroendocrine tumors (NET) have diverse clinical presentations. Patients with symptoms of hormone secretion may require specific medical interventions to control those symptoms prior to antitumor i...

    Authors: Matthew H Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier and James Yao

    Citation: Journal of Hematology & Oncology 2011 4:29

    Content type: Review

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  6. Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of neutrophilic granulocyte precursors, Recombinant G-CSF has been used for the treatment of congenital and ...

    Authors: Yongping Jiang, Wenhong Jiang, Yuchang Qiu and Wei Dai

    Citation: Journal of Hematology & Oncology 2011 4:28

    Content type: Research

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  7. Hemangiopericytoma is a rare and aggressive meningeal tumor. Although surgical resection is the standard treatment, hemangiopericytomas often recur with high incidences of metastasis. The purpose of this study...

    Authors: Anand Veeravagu, Bowen Jiang, Chirag G Patil, Marco Lee, Scott G Soltys, Iris C Gibbs and Steven D Chang

    Citation: Journal of Hematology & Oncology 2011 4:26

    Content type: Research

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  8. Although evaluation of at least 12 lymph nodes (LNs) is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate ...

    Authors: Chandrakumar Shanmugam, Robert B Hines, Nirag C Jhala, Venkat R Katkoori, Bin Zhang, James A Posey Jr, Harvey L Bumpers, William E Grizzle, Isam E Eltoum, Gene P Siegal and Upender Manne

    Citation: Journal of Hematology & Oncology 2011 4:25

    Content type: Research

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  9. Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marro...

    Authors: Andrea L George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman and Raj K Tiwari

    Citation: Journal of Hematology & Oncology 2011 4:24

    Content type: Review

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  10. Downregulation of the B-cell chronic lymphocytic leukemia (CLL)/lymphoma11B (BCL11B) gene by small interfering RNA (siRNA) leads to growth inhibition and apoptosis of the human T-cell acute lymphoblastic leukemia...

    Authors: Xin Huang, Qi Shen, Si Chen, Shaohua Chen, Lijian Yang, Jianyu Weng, Xin Du, Piotr Grabarczyk, Grzegorz K Przybylski, Christian A Schmidt and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:23

    Content type: Short report

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  11. The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis. We measured serum levels of osteopontin in 50 untreat...

    Authors: Aikaterini Sfiridaki, Spiros Miyakis, Constantina Pappa, George Tsirakis, Athanasios Alegakis, Vasileios Kotsis, Efstathios Stathopoulos and Michael Alexandrakis

    Citation: Journal of Hematology & Oncology 2011 4:22

    Content type: Letter to the Editor

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  12. Recently, we clarified at the molecular level novel chromosomal translocation t(14;14)(q11;q32) in a case of Sézary syndrome, which caused a rearrangement from TRAJ7 to the PPP2R5C gene. PPP2R5C is one of the reg...

    Authors: Haitao Zheng, Yu Chen, Shaohua Chen, Yuzhe Niu, Lijian Yang, Bo Li, Yuhong Lu, Suxia Geng, Xin Du and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:21

    Content type: Short report

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  13. Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized.

    Authors: Pan Jian, Zhao Wen Li, Tao Yan Fang, Wang Jian, Zhou Zhuan, Liao Xin Mei, Wu Shui Yan and Ni Jian

    Citation: Journal of Hematology & Oncology 2011 4:20

    Content type: Research

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  14. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) leads to a prolonged state of immunodeficiency and requires reconstitution of normal T-cell immunity. Signal joint T-cell receptor excision DNA ci...

    Authors: Xiuli Wu, Kanger Zhu, Xin Du, Shaohua Chen, Lijian Yang, Jufeng Wu, Qifa Liu and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:19

    Content type: Research

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  15. We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degr...

    Authors: Yuan Yuan, Yu-Min Liao, Chung-Tsen Hsueh and Hamid R Mirshahidi

    Citation: Journal of Hematology & Oncology 2011 4:16

    Content type: Review

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  16. Endometrial carcinoma is one of the most common gynecological malignancies in women. The diagnosis of the disease at early or premalignant stages is crucial for the patient's prognosis. To date, diagnosis and ...

    Authors: Yi-sheng Wang, Rui Cao, Hong Jin, Yi-ping Huang, Xiao-yan Zhang, Qing Cong, Yi-feng He and Cong-jian Xu

    Citation: Journal of Hematology & Oncology 2011 4:15

    Content type: Short report

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  17. The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This confo...

    Authors: Eric K Oermann, Simeng Suy, Heather N Hanscom, Joy S Kim, Sue Lei, Xia Yu, Guowei Zhang, Brook Ennis, JoyAnn P Rohan, Nathaniel Piel, Benjamin A Sherer, Devin Borum, Viola J Chen, Gerald P Batipps, Nicholas L Constantinople, Stephen W Dejter…

    Citation: Journal of Hematology & Oncology 2011 4:12

    Content type: Research

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  18. The objectives of the present study are to investigate the efficacy and safety profile of gemcitabine-based combinations in the treatment of locally advanced and metastatic pancreatic adenocarcinoma (LA/MPC).

    Authors: Jing Hu, Gang Zhao, Hong-Xia Wang, Lei Tang, Ying-Chun Xu, Yue Ma and Feng-Chun Zhang

    Citation: Journal of Hematology & Oncology 2011 4:11

    Content type: Research

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  19. Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every orga...

    Authors: Gerhard J Molderings, Stefan Brettner, Jürgen Homann and Lawrence B Afrin

    Citation: Journal of Hematology & Oncology 2011 4:10

    Content type: Review

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  20. Acute leukemia with coexisting Gilbert's syndrome treated by allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rarely reported. Here we described a case whose transaminase levels were almost no...

    Authors: Guo-Pan Yu, Qian-Li Jiang, Zhi-Ping Fan, Jie Zhao, Qi Wei, Jing Sun, Fan-Yi Meng and Qi-Fa Liu

    Citation: Journal of Hematology & Oncology 2011 4:9

    Content type: Letter to the Editor

    Published on:

  21. The unfolded protein response ( UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer c...

    Authors: Xuemei Li, Kezhong Zhang and Zihai Li

    Citation: Journal of Hematology & Oncology 2011 4:8

    Content type: Review

    Published on:

  22. BCR-ABL kinase domain (KD) mutation is the major mechanism contributing to suboptimal response to tyrosine kinase inhibitors (TKI) in BCR-ABL-positive chronic myeloid leukemia (CML) patients. T315I mutation, as o...

    Authors: Wanwisa Wongboonma, Wanna Thongnoppakhun and Chirayu U Auewarakul

    Citation: Journal of Hematology & Oncology 2011 4:7

    Content type: Research

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  23. The BCR-ABL1 translocation occurs in chronic myeloid leukemia (CML) and in 25% of cases with acute lymphoblastic leukemia (ALL). The advent of tyrosine kinase inhibitors (TKI) has fundamentally changed the treatm...

    Authors: Hilmar Quentmeier, Sonja Eberth, Julia Romani, Margarete Zaborski and Hans G Drexler

    Citation: Journal of Hematology & Oncology 2011 4:6

    Content type: Research

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  24. Chemotherapy combined concurrently with TKIs produced a negative interaction and failed to improve survival when compared with chemotherapy or TKIs alone in the treatment of non-small cell lung cancer (NSCLC)....

    Authors: Hua Cheng, She-Juan An, Song Dong, Yi-Fang Zhang, Xu-Chao Zhang, Zhi-Hong Chen, Jian-Su and Yi-Long Wu

    Citation: Journal of Hematology & Oncology 2011 4:5

    Content type: Research

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  25. JAK2V617F is found in the majority of patients with Ph- myeloproliferative neoplasms (MPNs) and has become a valuable marker for diagnosis of MPNs. However, it has also been found in many other hematological d...

    Authors: Wanming Zhao, Rufei Gao, Jiyun Lee, Shu Xing, Wanting T Ho, Xueqi Fu, Shibo Li and Zhizhuang J Zhao

    Citation: Journal of Hematology & Oncology 2011 4:4

    Content type: Short report

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  26. This phase I, randomized, multicenter, open-label study investigated the pharmacokinetics, safety, and efficacy of the oral mammalian target of rapamycin inhibitor everolimus in Chinese patients with advanced ...

    Authors: BingHe Xu, YiLong Wu, Lin Shen, DingWei Ye, Annette Jappe, Azzeddine Cherfi, Hui Wang and RuiRong Yuan

    Citation: Journal of Hematology & Oncology 2011 4:3

    Content type: Research

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  27. Our previous study had amplified antigen-specific full-length TCR α and β genes of clonally expanded T cells in the peripheral blood (PB) of patients with diffuse large B-cell lymphoma (DLBCL). The transfer of...

    Authors: Qingsong Yin, Xianfeng Zha, Lijian Yang, Shaohua Chen, Yubing Zhou, Xiuli Wu and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:2

    Content type: Research

    Published on:

  28. Myelodysplastic syndrome with isolated chromosome 5q deletion (5q- syndrome) is a clonal stem cell disorder characterized by ineffective hematopoiesis. MicroRNAs (miRNAs) are important regulators of hematopoie...

    Authors: Hana Votavova, Martina Grmanova, Michaela Dostalova Merkerova, Monika Belickova, Alzbeta Vasikova, Radana Neuwirtova and Jaroslav Cermak

    Citation: Journal of Hematology & Oncology 2011 4:1

    Content type: Short report

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  29. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the ea...

    Authors: Sun Zi-Min, Liu Hui-Lan, Geng Liang-Quan, Wang Xin-Bing, Yao Wen, Liu Xin, Ding Kai-Yang, Han Yong-Sheng, Yang Hui-Zhi, Tang Bo-lin, Tong Juan, Zhu Wei-Bo and Wang Zu-Yi

    Citation: Journal of Hematology & Oncology 2010 3:51

    Content type: Letter to the Editor

    Published on:

  30. Zearalenone (ZEA) is a phytoestrogen from Fusarium species. The aims of the study was to identify mode of human leukemic cell death induced by ZEA and the mechanisms involved.

    Authors: Ratana Banjerdpongchai, Prachya Kongtawelert, Orawan Khantamat, Chantragan Srisomsap, Daranee Chokchaichamnankit, Pantipa Subhasitanont and Jisnuson Svasti

    Citation: Journal of Hematology & Oncology 2010 3:50

    Content type: Research

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  31. We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphoc...

    Authors: Séverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, Jean-Pierre Kolb and Christian Billard

    Citation: Journal of Hematology & Oncology 2010 3:49

    Content type: Letter to the Editor

    Published on:

  32. We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells ...

    Authors: Shaohong Jiang, Xudong Ma, Yiqun Huang, Yunlu Xu, Ruiji Zheng and Jen-Wei Chiao

    Citation: Journal of Hematology & Oncology 2010 3:48

    Content type: Research

    Published on:

  33. Recent reports indicate that microRNAs (miRNAs) play a critical role in malignancies. However, the role that miRNAs play in pancreatic cancer remains to be determined. The purpose of this study was to investig...

    Authors: Xing J Zhang, Hua Ye, Cheng W Zeng, Bo He, Hua Zhang and Yue Q Chen

    Citation: Journal of Hematology & Oncology 2010 3:46

    Content type: Research

    Published on:

  34. Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenes...

    Authors: Patrick B Johnston, RuiRong Yuan, Franco Cavalli and Thomas E Witzig

    Citation: Journal of Hematology & Oncology 2010 3:45

    Content type: Review

    Published on:

  35. In a human T-cell acute lymphoblastic leukemia (T-ALL) cell line (Molt-4), siRNA-mediated suppression of BCL11B expression was shown to inhibit proliferation and induce apoptosis, functions which may be related t...

    Authors: Xin Huang, Shaohua Chen, Qi Shen, Lijian Yang, Bo Li, Liye Zhong, Suxia Geng, Xin Du and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2010 3:44

    Content type: Research

    Published on:

  36. Hepatocellular carcinoma (HCC) still is a big burden for China. In recent years, the third-generation platinum compounds have been proposed as potential active agents for HCC. However, more experimental and cl...

    Authors: Qiong Wu, Shu-Kui Qin, Feng-Meng Teng, Chang-Jie Chen and Rui Wang

    Citation: Journal of Hematology & Oncology 2010 3:43

    Content type: Research

    Published on:

  37. Breast cancer is a heterogeneous disease composed of different subtypes, characterized by their different clinicopathological characteristics, prognoses and responses to treatment. In the past decade, signific...

    Authors: Rafael Santana-Davila and Edith A Perez

    Citation: Journal of Hematology & Oncology 2010 3:42

    Content type: Review

    Published on:

  38. Mutations in the nucleophosmin (NPM1) gene have been solely associated with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 mutations in childhood AML, their relation to clinical and cy...

    Authors: Maria Braoudaki, Chrissa Papathanassiou, Katerina Katsibardi, Natalia Tourkadoni, Kalliopi Karamolegou and Fotini Tzortzatou-Stathopoulou

    Citation: Journal of Hematology & Oncology 2010 3:41

    Content type: Research

    Published on:

  39. Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER para...

    Authors: Saad Z Usmani, Robert D Bona, Gabriela Chiosis and Zihai Li

    Citation: Journal of Hematology & Oncology 2010 3:40

    Content type: Research

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  40. To report clinical efficacy and toxicity of fractionated CyberKnife radiosurgery for the treatment of hilar lung tumors.

    Authors: Keith Unger, Andrew Ju, Eric Oermann, Simeng Suy, Xia Yu, Saloomeh Vahdat, Deepa Subramaniam, K William Harter, Sean P Collins, Anatoly Dritschilo, Eric Anderson and Brian T Collins

    Citation: Journal of Hematology & Oncology 2010 3:39

    Content type: Short report

    Published on:

  41. Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences...

    Authors: Antonio Sacco, Ghayas C Issa, Yong Zhang, Yang Liu, Patricia Maiso, Irene M Ghobrial and Aldo M Roccaro

    Citation: Journal of Hematology & Oncology 2010 3:38

    Content type: Review

    Published on:

  42. MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features rela...

    Authors: Anuradha Budhu, Junfang Ji and Xin W Wang

    Citation: Journal of Hematology & Oncology 2010 3:37

    Content type: Review

    Published on:

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