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  1. Recent studies have identified myocyte enhancer factor 2C (MEF2C) as cooperating oncogene in acute myeloid leukemia (AML) and suggested a contribution to the aggressive nature of at least some subtypes of AML, ra...

    Authors: George S. Laszlo, Todd A. Alonzo, Chelsea J. Gudgeon, Kimberly H. Harrington, Alex Kentsis, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Soheil Meshinchi and Roland B. Walter
    Citation: Journal of Hematology & Oncology 2015 8:115
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2016 9:133

  2. Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (TSCM) cells, was shown to be one of t...

    Authors: Ling Xu, Yikai Zhang, Gengxin Luo and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2015 8:113
    Content type: Review Published on:

  4. The bispecific T cell engager blinatumomab has shown encouraging clinical activity in B-precursor acute lymphoblastic leukemia (ALL). However, about half of relapsed/refractory patients do not respond to thera...

    Authors: Thomas Köhnke, Christina Krupka, Johanna Tischer, Thomas Knösel and Marion Subklewe
    Citation: Journal of Hematology & Oncology 2015 8:111
    Content type: Case report Published on:

  5. Gap junctional intercellular communication (GJIC) is typically decreased in malignant tumors. Gap junction is not presented between hematopoietic cells but occurred in bone marrow stromal cells (BMSCs). Connex...

    Authors: Yao Liu, Qin Wen, Xue-lian Chen, Shi-jie Yang, Lei Gao, Li Gao, Cheng Zhang, Jia-li Li, Xi-xi Xiang, Kai Wan, Xing-hua Chen, Xi Zhang and Jiang-fan Zhong
    Citation: Journal of Hematology & Oncology 2015 8:110
    Content type: Rapid communication Published on:

  6. Small cell carcinoma/neuroendocrine prostate cancer (NePC) is a lethal, poorly understood prostate cancer (PCa) subtype. Controversy exists about the origin of NePC in this setting.

    Authors: Kunal C. Kadakia, Scott A. Tomlins, Saagar K. Sanghvi, Andi K. Cani, Kei Omata, Daniel H. Hovelson, Chia-Jen Liu and Kathleen A. Cooney
    Citation: Journal of Hematology & Oncology 2015 8:109
    Content type: Case report Published on:

  7. B-acute lymphoblastic leukemia (B-ALL) is derived from B cell progenitors. Recently, the development of appropriate combinations of chemotherapy and immunotherapy represents a promising approach for eliminatin...

    Authors: Dongmei Fan, Wei Li, Yuqi Yang, Xiaolong Zhang, Qing Zhang, Yan Yan, Ming Yang, Jianxiang Wang and Dongsheng Xiong
    Citation: Journal of Hematology & Oncology 2015 8:108
    Content type: Research Published on:

  8. In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-v...

    Authors: Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, Mohamad Mohty, Guillermo Sanz, Noel Milpied, Andrea Bacigalupo, Alessandro Rambaldi, Francesca Bonifazi, Alberto Bosi, Jorge Sierra, Ibrahim Yakoub-Agha, Josep Maria Ribera Santasusana, Eliane Gluckman and Arnon Nagler
    Citation: Journal of Hematology & Oncology 2015 8:107
    Content type: Research Published on:

  9. Multiple myeloma (MM) is an incurable haematological malignancy characterised by the clonal proliferation of malignant plasma cells within the bone marrow. We have previously identified pituitary tumour transf...

    Authors: Jacqueline E. Noll, Kate Vandyke, Duncan R. Hewett, Krzysztof M. Mrozik, Rachel J. Bala, Sharon A. Williams, Chung H. Kok and Andrew CW Zannettino
    Citation: Journal of Hematology & Oncology 2015 8:106
    Content type: Research Published on:

  10. Members of the Eph/ephrin gene families act as key regulators of cerebellar development during embryogenesis. Aberrant signaling of Eph family of receptor tyrosine kinases and their ephrin ligands has also bee...

    Authors: Shilpa Bhatia, Kellen Hirsch, Nimrah A. Baig, Olga Rodriguez, Olga Timofeeva, Kevin Kavanagh, Yi Chien Lee, Xiao-Jing Wang, Christopher Albanese and Sana D. Karam
    Citation: Journal of Hematology & Oncology 2015 8:105
    Content type: Rapid Communication Published on:

  11. Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. In addition, novel immunotherapeutics targeting B cell receptor signaling (e.g., ibrutinib), T cell r...

    Authors: Jingjing Wu, Jiaping Fu, Mingzhi Zhang and Delong Liu
    Citation: Journal of Hematology & Oncology 2015 8:104
    Content type: Review Published on:

  12. The oral proteasome inhibitor ixazomib is under phase 3 clinical investigation in multiple myeloma (MM) in combination with lenalidomide–dexamethasone. This study was conducted to investigate the pharmacokinet...

    Authors: Neeraj Gupta, Yeow Tee Goh, Chang-Ki Min, Jae Hoon Lee, Kihyun Kim, Raymond S. M. Wong, Chor Sang Chim, Michael J. Hanley, Huyuan Yang, Karthik Venkatakrishnan, Ai-Min Hui, Dixie-Lee Esseltine and Wee Joo Chng
    Citation: Journal of Hematology & Oncology 2015 8:103
    Content type: Research Article Published on:

  13. Addition of high-dose cytarabine (HDCA) to the conventional cyclophosphamide/total-body irradiation (CY/TBI) regimen significantly improved prognosis after cord blood transplantation (CBT) for adult acute myel...

    Authors: Yasuyuki Arai, Kazunari Aoki, June Takeda, Tadakazu Kondo, Tetsuya Eto, Shuichi Ota, Hisako Hashimoto, Takahiro Fukuda, Yukiyasu Ozawa, Yoshinobu Kanda, Chiaki Kato, Mineo Kurokawa, Koji Iwato, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta…
    Citation: Journal of Hematology & Oncology 2015 8:102
    Content type: Rapid Communication Published on:

  15. Herein, we describe the establishment and characterization of the first mixed-phenotype acute leukemia cell line (JIH-5). The JIH-5 cell line was established from leukemia cells with B lymphoid/myeloid phenoty...

    Authors: Nana Ping, Huiying Qiu, Qian Wang, Haiping Dai, Changgeng Ruan, Stefan Ehrentraut, Hans G. Drexler, Roderick A. F. MacLeod and Suning Chen
    Citation: Journal of Hematology & Oncology 2015 8:100
    Content type: Letter to the Editor Published on:

  16. Neuroblastoma currently has poor prognosis, therefore we proposed a new strategy by targeting neuroblastoma with genetically engineered anaerobic Salmonella (Sal-YB1).

    Authors: Zhu-Ling Guo, Bin Yu, Bo-Tao Ning, Shing Chan, Qiu-Bin Lin, James Chun-Bong Li, Jian-Dong Huang and Godfrey Chi-Fung Chan
    Citation: Journal of Hematology & Oncology 2015 8:99
    Content type: Research Published on:

  18. The BCR-ABL; breakpoint cluster region-Abelson point mutation T315I is resistant to ABL tyrosine kinase inhibitors. However, axitinib, a vascular endothelial growth factor receptor inhibitor, is effective agai...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka, Juri Sakuta and Kazuma Ohyashiki
    Citation: Journal of Hematology & Oncology 2015 8:97
    Content type: Letter to the Editor Published on:

  19. Monoclonal antibodies against CD20 molecule have been leading the revolution of lymphoma treatment. In addition to monoclonal antibodies against CD20 and CD30, novel agents of immunotherapeutics in clinical de...

    Authors: Jingjing Wu, Jiaping Fu, Mingzhi Zhang and Delong Liu
    Citation: Journal of Hematology & Oncology 2015 8:96
    Content type: Research Highlight Published on:

  20. Tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR-TKIs) are standard treatments for advanced non-small-cell lung cancer (NSCLC) patients harboring activating epidermal growth factor receptor...

    Authors: Wei Sun, Xun Yuan, Yijun Tian, Hua Wu, Hanxiao Xu, Guoqing Hu and Kongming Wu
    Citation: Journal of Hematology & Oncology 2015 8:95
    Content type: Review Published on:

  21. Bcl11b is a transcription factor important for T cell development and also a tumor-suppressor gene that is hemizygously inactivated in ~10 % human T cell acute lymphoblastic leukemia (T-ALL) and several murine...

    Authors: Kerice A. Pinkney, Wenxia Jiang, Brian J. Lee, Denis G. Loredan, Chen Li, Govind Bhagat and Shan Zha
    Citation: Journal of Hematology & Oncology 2015 8:94
    Content type: Letter to the Editor Published on:

  22. T cell function is crucial for the success of several novel immunotherapeutic strategies for the treatment of acute myeloid leukemia (AML). However, changes in phenotype and function of T cells have been descr...

    Authors: Frauke M. Schnorfeil, Felix S. Lichtenegger, Katharina Emmerig, Miriam Schlueter, Julia S. Neitz, Rika Draenert, Wolfgang Hiddemann and Marion Subklewe
    Citation: Journal of Hematology & Oncology 2015 8:93
    Content type: Research Article Published on:

  23. The recent FDA approval of ramucirumab (RAISE trial) has added a third agent to our existing armamentarium of angiogenesis inhibitors (bevacizumab and ziv-aflibercept) for the second-line treatment of metastat...

    Authors: Gaurav Goel and Weijing Sun
    Citation: Journal of Hematology & Oncology 2015 8:92
    Content type: Research Highlight Published on:

  25. Since the introduction of tyrosine kinase inhibitors (TKIs) into combination chemotherapy regimens, the majority of newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patie...

    Authors: Li Gao, Cheng Zhang, Lei Gao, Yao Liu, Yi Su, Sanbin Wang, Bin Li, Tonghua Yang, Zhong Yuan and Xi Zhang
    Citation: Journal of Hematology & Oncology 2015 8:90
    Content type: Research Article Published on:

  26. Gliomas are the most common types of primary brain tumors in the adult central nervous system. TMEM140 is identified as an amplified gene in the human gastric cancer genome. However, the function of TMEM140 in...

    Authors: Bin Li, Ming-Zhu Huang, Xiao-Qiang Wang, Bang-Bao Tao, Jun Zhong, Xu-Hui Wang, Wen-Chuan Zhang and Shi-Ting Li
    Citation: Journal of Hematology & Oncology 2015 8:89
    Content type: Research Article Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2015 8:101

  27. Alterations in DNA methylation are seen in cancers and have also been examined in clear cell renal cell carcinoma (ccRCC). Numerous tumor suppressor genes have been reported to be partially or completely silen...

    Authors: Niraj Shenoy, Nishanth Vallumsetla, Yiyu Zou, Jose Nahun Galeas, Makardhwaj Shrivastava, Caroline Hu, Katalin Susztak and Amit Verma
    Citation: Journal of Hematology & Oncology 2015 8:88
    Content type: Review Published on:

  28. The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical n...

    Authors: Behzad Kharabi Masouleh, Eric Chevet, Jens Panse, Edgar Jost, Michael O’Dwyer, Tim H. Bruemmendorf and Afshin Samali
    Citation: Journal of Hematology & Oncology 2015 8:87
    Content type: Review Published on:

  31. Small studies suggest an association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with primary graft failure (GF) following haploidentical stem cell transplantation, but primary graft...

    Authors: Ying-Jun Chang, Xiang-Yu Zhao, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Wei Han, Huan Chen, Feng-Rong Wang, Xiao-Dong Mo, Yuan-Yuan Zhang, Ming-Rui Huo, Xiao-Su Zhao, Kong Y, Kai-Yan Liu and Xiao-Jun Huang
    Citation: Journal of Hematology & Oncology 2015 8:84
    Content type: Research article Published on:

  32. Exosomes have emerged as a novel mode of intercellular communication. Exosomes can shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs from one cell to another, leading to the...

    Authors: Xu Zhang, Xiao Yuan, Hui Shi, Lijun Wu, Hui Qian and Wenrong Xu
    Citation: Journal of Hematology & Oncology 2015 8:83
    Content type: Review Published on:

  33. Combination therapy is a key strategy for minimizing drug resistance, a common problem in cancer therapy. The microtubule-depolymerizing agent vincristine is widely used in the treatment of acute leukemia. In ...

    Authors: Min-Wu Chao, Mei-Jung Lai, Jing-Ping Liou, Ya-Ling Chang, Jing-Chi Wang, Shiow-Lin Pan and Che-Ming Teng
    Citation: Journal of Hematology & Oncology 2015 8:82
    Content type: Research Article Published on:

  34. Bosutinib is a recently approved ABL inhibitor. In spite of the well-documented effectiveness of BCR-ABL inhibitors in treating chronic myeloid leukemia, development of resistance is a continuous clinical chal...

    Authors: Sara Redaelli, Pietro Perini, Monica Ceccon, Rocco Piazza, Roberta Rigolio, Mario Mauri, Frank Boschelli, Athina Giannoudis and Carlo Gambacorti-Passerini
    Citation: Journal of Hematology & Oncology 2015 8:81
    Content type: Research Article Published on:

  35. The infused autograft lymphocyte-to-monocyte ratio (A-LMR) is a prognostic factor for survival in B-cell lymphomas post-autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out ...

    Authors: Luis F. Porrata, David J. Inwards, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston, William J. Hogan and Svetomir N. Markovic
    Citation: Journal of Hematology & Oncology 2015 8:80
    Content type: Research Article Published on:

  36. Defects in filamin A (FLNA) gene could lead to low platelet counts and decreased surface expression of glycoprotein (GP) Ibα. Here, we report and investigate the FLNA genomic alteration of a case with Bernard-...

    Authors: Jiaming Li, KeSheng Dai, Zhaoyue Wang, Lijuan Cao, Xia Bai and Changgeng Ruan
    Citation: Journal of Hematology & Oncology 2015 8:79
    Content type: Letter to the Editor Published on:

  37. Severe aplastic anemia (SAA) is a rare disorder leading to bone marrow failure, which if left untreated, is invariably fatal. Conventional therapies with immunosuppressive therapy or allogeneic hematopoietic s...

    Authors: P. T. Vo, J. Pantin, C. Ramos, L. Cook, E. Cho, R. Kurlander, H. Khuu, J. Barrett, S. Leitman and R. W. Childs
    Citation: Journal of Hematology & Oncology 2015 8:78
    Content type: Case report Published on:

  38. Multiple myeloma (MM) is a hematologic malignancy that is characterized by the proliferation of abnormal bone marrow plasma cells (BMPC) and overproduction of immunoglobulin or light chains with evidence of en...

    Authors: Saurabh Chhabra, Sandeep Jain, Caroline Wallace, Feng Hong and Bei Liu
    Citation: Journal of Hematology & Oncology 2015 8:77
    Content type: Research Article Published on:

  39. To validate its efficacy in the context of the human immune system, a novel therapeutic vaccine of hGM-CSF/hTNFα surface-modified PC-3 cells against human prostate cancer was evaluated in the human peripheral ...

    Authors: Shouhua Lai, Zhiyong Huang, Yunting Guo, Yunqin Cui, Lei Wang, Weifeng Ren, Furong Ying, Hui Gao, Lingxia He, Tieli Zhou, Jiegen Jiang and Jimin Gao
    Citation: Journal of Hematology & Oncology 2015 8:76
    Content type: Letter to the Editor Published on:

  40. Circulating tumor cells (CTCs) are cells shed from tumors or metastatic sites and are a potential biomarker for cancer diagnosis, management, and prognostication. The majority of current studies use single or ...

    Authors: Sai Mun Leong, Karen ML Tan, Hui Wen Chua, Doreen Tan, Delly Fareda, Saabry Osmany, Mo-Huang Li, Steven Tucker and Evelyn SC Koay
    Citation: Journal of Hematology & Oncology 2015 8:75
    Content type: Review Published on:

  41. The prognostic importance of extramedullary involvement in patients with Waldenström macroglobulinemia (WM) at diagnosis and treatment options for these patients has not been well evaluated. In this study, we ...

    Authors: Xin Cao, Qing Ye, Robert Z. Orlowski, Xiaoxiao Wang, Sanam Loghavi, Meifeng Tu, Sheeba K. Thomas, Jatin Shan, Shaoying Li, Muzaffar Qazilbash, C. Cameron Yin, Donna Weber, Roberto N. Miranda, Zijun Y. Xu-Monette, L. Jeffrey Medeiros and Ken H. Young
    Citation: Journal of Hematology & Oncology 2015 8:74
    Content type: Research Article Published on:

  42. We identified three novel mutations (p.Gly39Arg, p.Lys157Glu, p.Cys379Gly) and one previously known mutation (p.Asp141Asn) in the von Willebrand factor propeptide from three von Willebrand disease patients. Al...

    Authors: Jie Yin, Zhenni Ma, Jian Su, Jiong-Wei Wang, Xiaojuan Zhao, Jing Ling, Xia Bai, Wanyan Ouyang, Zhaoyue Wang, Ziqiang Yu and Changgeng Ruan
    Citation: Journal of Hematology & Oncology 2015 8:73
    Content type: Letter to the Editor Published on:

  43. Previous studies indicated that upregulating TCRζ partially recovers T cell function in patients with leukemia. In this study, we characterized the cytokine profile of TCRζ-transfected T cells from acute myeloid ...

    Authors: Shaohua Chen, Xianfeng Zha, Li Shi, Lingling Zhou, Lijian Yang, Bo Li, Xiuli Wu, Jun Zhong, Tao Zhang, Yuhong Lu, Kanger Zhu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2015 8:72
    Content type: Letter to the Editor Published on:

  44. Increased plasma levels of proteasome have been associated with various neoplasms, especially myeloid malignancies. Little is known of the cellular origin and release mechanisms of such proteasome. We recently...

    Authors: Alessandro Pecci, Vittorio Necchi, Serena Barozzi, Agostina Vitali, Emanuela Boveri, Chiara Elena, Paolo Bernasconi, Patrizia Noris and Enrico Solcia
    Citation: Journal of Hematology & Oncology 2015 8:71
    Content type: Research Article Published on:

  45. The prognostic role of tumor-related parameters in diffuse large B cell lymphoma (DLBCL) is a matter of controversy.

    Authors: Alexandar Tzankov, Nora Leu, Simone Muenst, Darius Juskevicius, Dirk Klingbiel, Christoph Mamot and Stephan Dirnhofer
    Citation: Journal of Hematology & Oncology 2015 8:70
    Content type: Research Article Published on:

  46. The genomic landscape of children with acute myeloid leukemia (AML) who do not carry any cytogenetic abnormality (CN-AML) is particularly heterogeneous and challenging, being characterized by different clinica...

    Authors: Marco Togni, Riccardo Masetti, Martina Pigazzi, Annalisa Astolfi, Daniele Zama, Valentina Indio, Salvatore Serravalle, Elena Manara, Valeria Bisio, Carmelo Rizzari, Giuseppe Basso, Andrea Pession and Franco Locatelli
    Citation: Journal of Hematology & Oncology 2015 8:69
    Content type: Letter to the Editor Published on:

  47. MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate...

    Authors: Srivatsava Naidu, Peter Magee and Michela Garofalo
    Citation: Journal of Hematology & Oncology 2015 8:68
    Content type: Review Published on:

  48. SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating enzyme required for numerous important protein SUMOylation, abnormal of which is associated with carcinogenesis. SAE2 inactivation was recently...

    Authors: Xiaoke Liu, Yong Xu, Zongguo Pang, Fuchun Guo, Qing Qin, Tao Yin, Yaxiong Sang, Chengjun Feng, Xiaoyu Li, Li Jiang, Pei Shu and Yongsheng Wang
    Citation: Journal of Hematology & Oncology 2015 8:67
    Content type: Research Article Published on:

  49. Recurrent, metastatic mesenchymal myxoid tumors of the gynecologic tract present a management challenge as there is minimal evidence to guide systemic therapy. Such tumors also present a diagnostic dilemma, as...

    Authors: Vivek Subbiah, Caitlin McMahon, Shreyaskumar Patel, Ralph Zinner, Elvio G Silva, Julia A. Elvin, Ishwaria M. Subbiah, Chimela Ohaji, Dhakshina Moorthy Ganeshan, Deepa Anand, Charles F. Levenback, Jenny Berry, Tim Brennan, Juliann Chmielecki, Zachary R. Chalmers, John Mayfield…
    Citation: Journal of Hematology & Oncology 2015 8:66
    Content type: RESEARCH ARTICLE Published on:

  50. Plasmablastic lymphoma (PBL) is a rare aggressive neoplasm with lymphoid and plasmacytic differentiation that is commonly associated with immunodeficiency and an unfavorable prognosis. Clinicopathologic featur...

    Authors: Sanam Loghavi, Khaled Alayed, Tariq N. Aladily, Zhuang Zuo, Siok-Bian Ng, Guilin Tang, Shimin Hu, C. Cameron Yin, Roberto N. Miranda, L. Jeffrey Medeiros and Joseph D. Khoury
    Citation: Journal of Hematology & Oncology 2015 8:65
    Content type: Research article Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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