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  1. Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies. TRAF3, a critical regulator of B cell surviva...

    Authors: Shanique KE Edwards, Jacqueline Baron, Carissa R Moore, Yan Liu, David H Perlman, Ronald P Hart and Ping Xie
    Citation: Journal of Hematology & Oncology 2014 7:56
    Content type: Research Published on:

  2. FENDRR is a long non-coding RNAs (lncRNA) that binds to polycomb repressive complexe 2 (PRC2) to epigenetically regulate the expression of its target gene. The clinical role of FENDRR in carcinomas remains yet to...

    Authors: Tong-peng Xu, Ming-de Huang, Rui Xia, Xin-xin Liu, Ming Sun, Li Yin, Wen-ming Chen, Liang Han, Er-bao Zhang, Rong Kong, Wei De and Yong-qian Shu
    Citation: Journal of Hematology & Oncology 2014 7:63
    Content type: Research Published on:

  3. Improvement of current GVHD prophylactic therapies remains an important goal in the allo-HSCT. We have described a novel prophylaxis regimen in a single institution trial. The Chinese Bone Marrow Transplant Co...

    Authors: Yong-rong Lai, Yu-hong Chen, Deng-ming Hu, Ming Jiang, Qi-fa Liu, Lin Liu, Jian Hou, Paul Schwarzenberger, Qiao-chuan Li, Zhong-ming Zhang, Kai-yan Liu and Xiao-jun Huang
    Citation: Journal of Hematology & Oncology 2014 7:59
    Content type: Research Published on:

  4. Survivin is overexpressed in cancer cells and plays a crucial role in apoptosis evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of various DNA-damaging agents. Here, we e...

    Authors: Qin Qin, Hongyan Cheng, Jing Lu, Liangliang Zhan, Jianchao Zheng, Jing Cai, Xi Yang, Liping Xu, Hongcheng Zhu, Chi Zhang, Jia Liu, Jianxin Ma, Xizhi Zhang, Shengbin Dai and Xinchen Sun
    Citation: Journal of Hematology & Oncology 2014 7:62
    Content type: Research Published on:

  5. Telomeres are specific nucleoprotein structures at the ends of eukaryotic chromosomes. Telomeres and telomere-associated proteins maintain genome stability by protecting the ends of chromosomes from fusion and...

    Authors: Limengmeng Wang, Haowen Xiao, Xing Zhang, Chong Wang and He Huang
    Citation: Journal of Hematology & Oncology 2014 7:61
    Content type: Review Published on:

  6. Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in th...

    Authors: Johana M Isaza-Correa, Zheng Liang, Anke van den Berg, Arjan Diepstra and Lydia Visser
    Citation: Journal of Hematology & Oncology 2014 7:57
    Content type: Review Published on:

  7. The aberrant hemostasis is a common manifestation of cancer, and venous thromboembolism (VTE) is the second leading cause of cancer patients’ mortality. Tissue factor (TF), comprising of a 47-kDa transmembrane...

    Authors: Xiao Han, Bo Guo, Yongsheng Li and Bo Zhu
    Citation: Journal of Hematology & Oncology 2014 7:54
    Content type: Review Published on:

  8. Acute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, ...

    Authors: Wenxiu Qi, Chengzhi Xie, Chunhuai Li, J Timothy Caldwell, Holly Edwards, Jeffrey W Taub, Yue Wang, Hai Lin and Yubin Ge
    Citation: Journal of Hematology & Oncology 2014 7:53
    Content type: Research Published on:

  9. Germ cell tumors (GCT) are the most common solid tumors in adolescent and young adult males (age 15 and 35 years) and remain one of the most curable of all solid malignancies. However a subset of patients will...

    Authors: Vivek Subbiah, Funda Meric-Bernstam, Gordon B Mills, Kenna R Mills Shaw, Ann Marie Bailey, Priya Rao, John F Ward and Lance C Pagliaro
    Citation: Journal of Hematology & Oncology 2014 7:52
    Content type: Research Published on:

  10. TERT promoter mutations were recently discovered in melanoma by next generation sequencing. Subsequently, several malignancies including urothelial carcinoma were also found to be associated with the same TERT pr...

    Authors: Xiaoyong Zheng, Jian Zhuge, Stephania M Bezerra, Sheila F Faraj, Enrico Munari, John T Fallon, Ximing J Yang, Pedram Argani, George J Netto and Minghao Zhong
    Citation: Journal of Hematology & Oncology 2014 7:47
    Content type: Research Published on:

  12. Risk stratification, detection of minimal residual disease (MRD), and implementation of novel therapeutic agents have improved outcome in acute lymphoblastic leukemia (ALL), but survival of adult patients with...

    Authors: Isabelle Bartram, Nicola Gökbuget, Cornelia Schlee, Sandra Heesch, Lars Fransecky, Stefan Schwartz, Reingard Stuhlmann, Kerstin Schäfer-Eckhart, Michael Starck, Albrecht Reichle, Dieter Hoelzer, Claudia D Baldus and Martin Neumann
    Citation: Journal of Hematology & Oncology 2014 7:51
    Content type: Research Published on:

  13. Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs). We performed high resolution melting analysis and Sanger sequencing togethe...

    Authors: Zhiyuan Wu, Xinju Zhang, Xiao Xu, Yuming Chen, Tingting Hu, Zhihua Kang, Shibao Li, Hua Wang, Weiwei Liu, Xiaochao Ma and Ming Guan
    Citation: Journal of Hematology & Oncology 2014 7:48
    Content type: Research Published on:

  14. Recent advances suggest fallopian tube as the main cellular source for women’s pelvic serous carcinoma (PSC). In addition to TP53 mutations, many other genetic changes are involved in pelvic serous carcinogenesis...

    Authors: Yiying Wang, Yue Wang, Dake Li, Lingmin Li, Wenjing Zhang, Guang Yao, Zhong Jiang and Wenxin Zheng
    Citation: Journal of Hematology & Oncology 2014 7:49
    Content type: Short report Published on:

  15. The Src homology-2 domain protein B (Shb) is an adapter protein operating downstream of several tyrosine kinase receptors and consequently Shb regulates various cellular responses. Absence of Shb was recently ...

    Authors: Karin Gustafsson, Maria Jamalpour, Camilla Trinh, Michael G Kharas and Michael Welsh
    Citation: Journal of Hematology & Oncology 2014 7:45
    Content type: Research Published on:

  16. Patients with DLBCL who are ineligible for or have relapsed after aggressive salvage chemotherapy have a poor prognosis. CD40 is expressed on multiple B-cell neoplasms including DLBCL and is a potential target...

    Authors: Sven de Vos, Andres Forero-Torres, Stephen M Ansell, Brad Kahl, Bruce D Cheson, Nancy L Bartlett, Richard R Furman, Jane N Winter, Henry Kaplan, John Timmerman, Nancy C Whiting, Jonathan G Drachman and Ranjana Advani
    Citation: Journal of Hematology & Oncology 2014 7:44
    Content type: Research Published on:

  17. MicroRNA dysregulation is a common event in leukemia. Polymorphisms in microRNA-binding sites (miRSNPs) in target genes may alter the strength of microRNA interaction with target transcripts thereby affecting ...

    Authors: Agnieszka Dzikiewicz-Krawczyk, Anna Macieja, Ewa Mały, Danuta Januszkiewicz-Lewandowska, Maria Mosor, Marta Fichna, Ewa Strauss and Jerzy Nowak
    Citation: Journal of Hematology & Oncology 2014 7:43
    Content type: Research Published on:

  18. MicroRNAs (miRNAs) are coordinators of cellular differentiation, including granulopoiesis. Although differential expression of many miRNAs is associated with the maturation of granulocytes, analysis of differe...

    Authors: Justin JL Wong, William Ritchie, Dadi Gao, Katherine A Lau, Maria Gonzalez, Anupma Choudhary, Ryan J Taft, John EJ Rasko and Jeff Holst
    Citation: Journal of Hematology & Oncology 2014 7:42
    Content type: Research Published on:

  19. This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.

    Authors: M Kay Garcia, Lorenzo Cohen, Ying Guo, Yuhong Zhou, Bing You, Joseph Chiang, Robert Z Orlowski, Donna Weber, Jatin Shah, Raymond Alexanian, Sheeba Thomas, Jorge Romaguera, Liang Zhang, Maria Badillo, Yiming Chen, Qi Wei…
    Citation: Journal of Hematology & Oncology 2014 7:41
    Content type: Research Published on:

  20. Dysregulated microRNA (miRNA) expression contributes to cancer cell proliferation, apoptosis and angiogenesis. Angiogenesis is a hallmark of multiple myeloma (MM) development and progression. Argonaute 2 (AGO2...

    Authors: Shuang Wu, Wenjun Yu, Xiaoyan Qu, Rong Wang, Ji Xu, Qiguo Zhang, Jiaren Xu, Jianyong Li and Lijuan Chen
    Citation: Journal of Hematology & Oncology 2014 7:40
    Content type: Research Published on:

  21. Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR), play a crucial role in ovarian carcinogenesis. To date, EGFR targeting has shown limited antitumor effects in ovari...

    Authors: Yi Yu, Mingxing Zhang, Xiaoyan Zhang, Qingqing Cai, Shanshan Hong, Wei Jiang and Congjian Xu
    Citation: Journal of Hematology & Oncology 2014 7:39
    Content type: Research Published on:

  22. The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirec...

    Authors: Ilaria Bononi, Paolo Perri, Alice Begnardi, Alessandra Martini, Elisa Mazzoni, Silvia Bosi, Silvia Pietrobon, Adolfo Sebastiani, Mauro Tognon and Fernanda Martini
    Citation: Journal of Hematology & Oncology 2014 7:38
    Content type: Letter to the Editor Published on:

  23. The ABL kinase inhibitor imatinib is highly effective in treating most, but not all, patients with chronic myeloid leukemia (CML). This is because residual CML cells are generally present in the bone marrow mi...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Seiichiro Katagiri, Yuko Tanaka and Kazuma Ohyashiki
    Citation: Journal of Hematology & Oncology 2014 7:37
    Content type: Research Published on:

  24. A 50-year-old woman was diagnosed with acute myeloid leukemia (AML). She has history of thrombocytopenia for 25 years and a significant family history of thrombocytopenia, affecting her mother, siblings and th...

    Authors: Juehua Gao, Ryan D Gentzler, Andrew E Timms, Marshall S Horwitz, Olga Frankfurt, Jessica K Altman and LoAnn C Peterson
    Citation: Journal of Hematology & Oncology 2014 7:36
    Content type: Case report Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2015 8:131

  25. The normal accumulation of adult α and β globins in definitive erythrocytes is critically dependent upon processes that ensure that the cognate mRNAs are maintained at high levels in transcriptionally silent, ...

    Authors: Zhenning He, Decheng Song, Sebastiaan van Zalen and J Eric Russell
    Citation: Journal of Hematology & Oncology 2014 7:35
    Content type: Research Published on:

  26. Expression of CD44 splice isoforms has been previously reported to correlate with inferior outcomes in DLBCL patients treated with CHOP therapy. However, it is unclear whether this observation remains valid in...

    Authors: Xiaolei Wei, Meng Xu, Yongqiang Wei, Fen Huang, Tong Zhao, Xiangzhao Li, Ru Feng and B Hilda Ye
    Citation: Journal of Hematology & Oncology 2014 7:34
    Content type: Letter to the Editor Published on:

  27. CD19 is a B cell lineage specific surface receptor whose broad expression, from pro-B cells to early plasma cells, makes it an attractive target for the immunotherapy of B cell malignancies. In this study we p...

    Authors: Caroline S Breton, Aimable Nahimana, Dominique Aubry, Julie Macoin, Pierre Moretti, Martin Bertschinger, Samuel Hou, Michel A Duchosal and Jonathan Back
    Citation: Journal of Hematology & Oncology 2014 7:33
    Content type: Research Published on:

  28. Children with Down syndrome (DS) have an increased risk for acute lymphoblastic leukemia (ALL). Although previous studies have shown that DS-ALL differs clinically and genetically from non-DS-ALL, much remains...

    Authors: Catarina Lundin, Erik Forestier, Mette Klarskov Andersen, Kirsi Autio, Gisela Barbany, Lucia Cavelier, Irina Golovleva, Sverre Heim, Kristiina Heinonen, Randi Hovland, Johann H Johannsson, Eigil Kjeldsen, Ann Nordgren, Lars Palmqvist and Bertil Johansson
    Citation: Journal of Hematology & Oncology 2014 7:32
    Content type: Research Published on:

  29. The hematopoietic syndrome of the acute radiation syndrome (HSARS) is a life-threatening condition in humans exposed to total body irradiation (TBI); no drugs are approved for treating this condition. Recombin...

    Authors: Zoya Gluzman-Poltorak, Sarita R Mendonca, Vladimir Vainstein, Hue Kha and Lena A Basile
    Citation: Journal of Hematology & Oncology 2014 7:31
    Content type: Research Published on:

  30. Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL), which represents a rapidly progressing malignancy arising in HIV-infected patients. Conventional chem...

    Authors: Lu Dai, Yueyu Cao, Yihan Chen, Chris Parsons and Zhiqiang Qin
    Citation: Journal of Hematology & Oncology 2014 7:30
    Content type: Research Published on:

  31. A blockade of CD44 is considered a therapeutic option for the elimination of leukemia initiating cells. However, anti-panCD44 can interfere with hematopoiesis. Therefore we explored, whether a CD44 variant iso...

    Authors: Ulrike Erb, Amelie Pajip Megaptche, Xiaoyu Gu, Markus W Büchler and Margot Zöller
    Citation: Journal of Hematology & Oncology 2014 7:29
    Content type: Research Published on:

  32. Cancer stem cells (CSCs) play a key role in the posthepatectomy recurrence of hepatocellular carcinoma (HCC). CD133+ HCC cells exhibit liver CSC–like properties, and CSC differentiation–inducing therapy may lead ...

    Authors: Ke-Zhi Zhang, Qiang-Bo Zhang, Quan-Bao Zhang, Hui-Chuan Sun, Jian-Yang Ao, Zong-Tao Chai, Xiao-Dong Zhu, Lu Lu, Yuan-Yuan Zhang, Yang Bu, Ling-Qun Kong and Zhao-You Tang
    Citation: Journal of Hematology & Oncology 2014 7:28
    Content type: Research Published on:

  33. PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism. The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants a...

    Authors: David J Araten, Anna Paola Iori, Karen Brown, Giovanni Fernando Torelli, Walter Barberi, Fiammetta Natalino, Maria Stefania De Propris, Corrado Girmenia, Filippo Maria Salvatori, Orly Zelig, Robin Foà and Lucio Luzzatto
    Citation: Journal of Hematology & Oncology 2014 7:27
    Content type: Short report Published on:

  34. The FIP1L1-PDGFRA rearrangement results in constitutive activation of the tyrosine kinase PDGFRA. Neoplasms harboring this rearrangement are responsive to imatinib mesylate at doses much lower than those recommen...

    Authors: Shilpan Shah, Sanam Loghavi, Guillermo Garcia-Manero and Joseph D Khoury
    Citation: Journal of Hematology & Oncology 2014 7:26
    Content type: Case report Published on:

  35. Myeloproliferative neoplasms (MPNs) are blood malignancies manifested in increased production of red blood cells, white blood cells, and/or platelets. A major molecular lesion associated with the diseases is J...

    Authors: Kaiyao Shi, Wanke Zhao, Yun Chen, Wanting Tina Ho, Ping Yang and Zhizhuang Joe Zhao
    Citation: Journal of Hematology & Oncology 2014 7:25
    Content type: Research Published on:

  36. Brentuximab vedotin is a CD30-directed antibody-drug conjugate. Retreatment with brentuximab vedotin monotherapy was investigated in patients with CD30-positive Hodgkin lymphoma (HL) or systemic anaplastic lar...

    Authors: Nancy L Bartlett, Robert Chen, Michelle A Fanale, Pauline Brice, Ajay Gopal, Scott E Smith, Ranjana Advani, Jeffrey V Matous, Radhakrishnan Ramchandren, Joseph D Rosenblatt, Dirk Huebner, Pamela Levine, Laurie Grove and Andres Forero-Torres
    Citation: Journal of Hematology & Oncology 2014 7:24
    Content type: Research Published on:

  37. 8-chloro-adenosine (8-Cl-Ado) is a unique ribonucleoside analog which is currently in a phase I clinical trial for hematological malignancies. Previously, we demonstrated in breast cancer cells that a 3-day tr...

    Authors: Christine M Stellrecht, Hima V Vangapandu, Xiao-Feng Le, Weiqun Mao and Shujun Shentu
    Citation: Journal of Hematology & Oncology 2014 7:23
    Content type: Research Published on:

  38. AST1306 is an orally active irreversible small molecule inhibitor of EGFR (erbB1), HER2 (erbB2) and HER4 (erbB4) signaling. This is a phase I, open-label, dose-escalation study to evaluate the safety and toler...

    Authors: Jian Zhang, Junning Cao, Jin Li, Yifan Zhang, Zhiyu Chen, Wei Peng, Si Sun, Naiqing Zhao, Jiachen Wang, Dafang Zhong, Xiaofang Zhang and Jing Zhang
    Citation: Journal of Hematology & Oncology 2014 7:22
    Content type: Research Published on:

  39. Cysteine- rich secretory protein 3 (CRISP3) prognostic significance in prostate cancer (PCA) has generated mixed result. Herein, we investigated and independently validated CRISP3 expression in relation to ERG an...

    Authors: Samir Al Bashir, Mohammed Alshalalfa, Samar A Hegazy, Michael Dolph, Bryan Donnelly and Tarek A Bismar
    Citation: Journal of Hematology & Oncology 2014 7:21
    Content type: Research Published on:

  40. Patients with locally advanced and high-risk prostate cancer (LAPC) are prone to experience biochemical recurrence despite radical prostatectomy (RP). We evaluated feasibility, safety and activity of a neoadju...

    Authors: Mark Thalgott, Thomas Horn, Matthias M Heck, Tobias Maurer, Matthias Eiber, Margitta Retz, Michael Autenrieth, Kathleen Herkommer, Bernd J Krause, Jürgen E Gschwend, Uwe Treiber and Hubert R Kübler
    Citation: Journal of Hematology & Oncology 2014 7:20
    Content type: Research Published on:

  41. Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET), play important roles in embryogenesis, stem cell biology, and cancer progression. EMT can be regu...

    Authors: Fei Guo, Brittany C Parker Kerrigan, Da Yang, Limei Hu, Ilya Shmulevich, Anil K Sood, Fengxia Xue and Wei Zhang
    Citation: Journal of Hematology & Oncology 2014 7:19
    Content type: Review Published on:

  43. Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) is frequently observed in hematopoietic malignancies. Although PTEN has been implicated in maintaining the quiescence of hematopoietic stem ce...

    Authors: Zhi-Wei Dong, Chun-Guang Ren, Yu Xia, Dan Su, Ting-Ting Du, Hong-Bo Fan, Hao Yuan, Lei Wang, Mei Dong, Wei-Chun Li, Yi Jin, Yi Chen, Min Deng, Ting-Xi Liu, Ai-Hua Gu and Yong Zhou
    Citation: Journal of Hematology & Oncology 2014 7:17
    Content type: Research Published on:

  44. Donor cell engraftment is critical for the success of allogeneic bone marrow transplants. Graft failure is a result of donor cells either failing to engraft initially or being eliminated at later time points. ...

    Authors: Katarzyna A Darlak, Ying Wang, Jian-Ming Li, Wayne AC Harris, Cynthia R Giver, Chunzi Huang and Edmund K Waller
    Citation: Journal of Hematology & Oncology 2014 7:16
    Content type: Research Published on:

  45. Although dendritic cell (DC) vaccines are considered to be promising treatments for advanced cancer, their production and administration is costly and labor-intensive. We developed a novel immunotherapeutic ag...

    Authors: Jianping Yuan, Satoshi Kashiwagi, Patrick Reeves, Jean Nezivar, Yuan Yang, Nadiah Hashim Arrifin, Mai Nguyen, Gilberte Jean-Mary, Xiaoyun Tong, Paramjit Uppal, Svetlana Korochkina, Ben Forbes, Tao Chen, Elda Righi, Roderick Bronson, Huabiao Chen…
    Citation: Journal of Hematology & Oncology 2014 7:15
    Content type: Research Published on:

  48. Infantile hemangioma (IH), which is the most common tumor in infants, is a benign vascular neoplasm resulting from the abnormal proliferation of endothelial cells and pericytes. For nearly a century, researche...

    Authors: Yi Ji, Siyuan Chen, Kai Li, Li Li, Chang Xu and Bo Xiang
    Citation: Journal of Hematology & Oncology 2014 7:13
    Content type: Review Published on:

  49. Romidepsin is a structurally unique, potent, bicyclic class 1 selective histone deacetylase inhibitor approved by the US Food and Drug Administration for the treatment of patients with cutaneous T-cell lymphom...

    Authors: Bertrand Coiffier, Barbara Pro, H Miles Prince, Francine Foss, Lubomir Sokol, Matthew Greenwood, Dolores Caballero, Franck Morschhauser, Martin Wilhelm, Lauren Pinter-Brown, Swaminathan Padmanabhan Iyer, Andrei Shustov, Tina Nielsen, Jean Nichols, Julie Wolfson, Barbara Balser…
    Citation: Journal of Hematology & Oncology 2014 7:11
    Content type: Research Published on:

  50. Multicentric Castleman disease (MCD) is a lymphoproliferative disorder caused by human herpesvirus 8 (HHV8) infection HIV associated MCD (HIV-MCD) presents with various clinical symptoms. Many HIV-negative MCD...

    Authors: Azusa Nagao, Shoko Nakazawa and Hideji Hanabusa
    Citation: Journal of Hematology & Oncology 2014 7:10
    Content type: Case report Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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