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  1. Breast cancer is a heterogeneous disease composed of different subtypes, characterized by their different clinicopathological characteristics, prognoses and responses to treatment. In the past decade, signific...

    Authors: Rafael Santana-Davila and Edith A Perez
    Citation: Journal of Hematology & Oncology 2010 3:42
    Content type: Review Published on:

  2. Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER para...

    Authors: Saad Z Usmani, Robert D Bona, Gabriela Chiosis and Zihai Li
    Citation: Journal of Hematology & Oncology 2010 3:40
    Content type: Research Published on:

  3. To report clinical efficacy and toxicity of fractionated CyberKnife radiosurgery for the treatment of hilar lung tumors.

    Authors: Keith Unger, Andrew Ju, Eric Oermann, Simeng Suy, Xia Yu, Saloomeh Vahdat, Deepa Subramaniam, K William Harter, Sean P Collins, Anatoly Dritschilo, Eric Anderson and Brian T Collins
    Citation: Journal of Hematology & Oncology 2010 3:39
    Content type: Short report Published on:

  4. Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences...

    Authors: Antonio Sacco, Ghayas C Issa, Yong Zhang, Yang Liu, Patricia Maiso, Irene M Ghobrial and Aldo M Roccaro
    Citation: Journal of Hematology & Oncology 2010 3:38
    Content type: Review Published on:

  5. MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features rela...

    Authors: Anuradha Budhu, Junfang Ji and Xin W Wang
    Citation: Journal of Hematology & Oncology 2010 3:37
    Content type: Review Published on:

  6. Optimal conditioning therapy for hematopoietic cell transplantation (HCT) in acute myelogenous leukemia (AML) remains undefined. We retrospectively compared outcomes of a consecutive series of 51 AML patients ...

    Authors: Joseph Pidala, Jongphil Kim, Claudio Anasetti, Mohamed A Kharfan-Dabaja, Taiga Nishihori, Teresa Field, Janelle Perkins, Lia Perez and Hugo F Fernandez
    Citation: Journal of Hematology & Oncology 2010 3:36
    Content type: Research Published on:

  8. Mantle cell lymphoma is a lymphoid entity characterized by adenopathy, blood and bone marrow involment which only recurrent mucosal localisation is the lymphomatoid polyposis. Few other mucosal infiltrations h...

    Authors: Jean-Christophe Ianotto, Adrian Tempescul, Jean-Richard Eveillard, Norbert André, Frederic Morel, Isabelle Quintin-Roué and Christian Berthou
    Citation: Journal of Hematology & Oncology 2010 3:34
    Content type: Letter to the Editor Published on:

  9. Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the patho...

    Authors: Xueling GE and Xin Wang
    Citation: Journal of Hematology & Oncology 2010 3:33
    Content type: Review Published on:

  10. We describe a case of multiple myeloma (MM) and secondary plasma cell leukemia (PCL) secreting IgE-kappa immunoglobulin. To our knowledge, only 2 cases of IgE-producing secondary PCL have been reported in the ...

    Authors: Giampaolo Talamo, William Castellani and Nathan G Dolloff
    Citation: Journal of Hematology & Oncology 2010 3:32
    Content type: Case report Published on:

  11. We report a 49-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with trastuzumab-containing regimen. He underwent esoph...

    Authors: Jun Wang, George W Saukel, Carlos A Garberoglio, Wichit Srikureja and Chung-Tsen Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:31
    Content type: Case report Published on:

  12. Mantle cell lymphoma (MCL) is a rare and aggressive type of B-cell non-Hodgkin's lymphoma. Patients become progressively refractory to conventional chemotherapy, and their prognosis is poor. However, a 38% rem...

    Authors: Li Wang, Wen-Yu Shi, Zhi-Yuan Wu, Mariana Varna, Ai-Hua Wang, Li Zhou, Li Chen, Zhi-Xiang Shen, He Lu, Wei-Li Zhao and Anne Janin
    Citation: Journal of Hematology & Oncology 2010 3:30
    Content type: Case report Published on:

  13. The Gγ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about Gγ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This stud...

    Authors: Rong Rong Liu, Ming Yue Wang and Yong Rong Lai
    Citation: Journal of Hematology & Oncology 2010 3:29
    Content type: Letter to the Editor Published on:

  14. Acute promyelocytic leukemia (APL) is a blood cancer that affects people of all ages and strikes about 1,500 patients in the United States each year. The standard treatment of APL has been based on the combine...

    Authors: Clement Yedjou, Paul Tchounwou, John Jenkins and Robert McMurray
    Citation: Journal of Hematology & Oncology 2010 3:28
    Content type: Research Published on:

  15. In newly diagnosed patients with Hodgkin lymphoma (HL) the effect of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD)-related neutropenia on chemotherapy delivery is poorly documented. The aim of thi...

    Authors: Matthias Schwenkglenks, Ruth Pettengell, Thomas D Szucs, Eva Culakova and Gary H Lyman
    Citation: Journal of Hematology & Oncology 2010 3:27
    Content type: Short report Published on:

  16. Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplast...

    Authors: Clara Hwang and Elisabeth I Heath
    Citation: Journal of Hematology & Oncology 2010 3:26
    Content type: Review Published on:

  17. The ring chromosome is a circular, structural abnormality composed of either multiple chromosomes or a single chromosome with loss of genetic material at one or both ends. This chromosomal rearrangement is oft...

    Authors: Shanthi Sivendran, Stephen Gruenstein, Adriana K Malone and Vesna Najfeld
    Citation: Journal of Hematology & Oncology 2010 3:25
    Content type: Case report Published on:

  18. We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subseq...

    Authors: Marnelli A Bautista-Quach, Yu-Min Liao and Chung-Tsen Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:24
    Content type: Case report Published on:

  19. Management of localized primary gastric B lymphoma (PGL) remains controversial. The aim of this study is to compare two treatments: chemotherapy alone and surgery plus chemotherapy.

    Authors: Yassir Sbitti, Nabil Ismaili, Youssef Bensouda, Habiba Kadiri, Mohammed Ichou and Hassan Errihani
    Citation: Journal of Hematology & Oncology 2010 3:23
    Content type: Short report Published on:

  20. With conventional radiation technique alone, it is difficult to deliver radical treatment (≥ 60 Gy) to gliomas that are close to critical structures without incurring the risk of late radiation induced complic...

    Authors: Eric Oermann, Brian T Collins, Kelly T Erickson, Xia Yu, Sue Lei, Simeng Suy, Heather N Hanscom, Joy Kim, Hyeon U Park, Andrew Eldabh, Christopher Kalhorn, Kevin McGrail, Deepa Subramaniam, Walter C Jean and Sean P Collins
    Citation: Journal of Hematology & Oncology 2010 3:22
    Content type: Research Published on:

  21. There has been little literature about leukemia epidemiology in Nanjing in recent years. We aimed to explore the incidence rate, gender and age distribution of leukemia in Nanjing using the leukemia database o...

    Authors: Bao-An Chen, Zhi-Hu Huang, Xiao-Ping Zhang, Jian Ou-Yang, Jian-Yong Li, Yong-Ping Zhai, Xue-Mei Sun, Yan-Li Xu, Qin Lu, Jian-Min Wang, Dong Li, Hui Liao, Zhi-Xiang Shen, Yan-Yan Wang, Xiao-Jing Yu, Hui Ye…
    Citation: Journal of Hematology & Oncology 2010 3:21
    Content type: Letter to the Editor Published on:

  22. A 24-year-old female patient was diagnosed with classic Hodgkin's lymphoma in clinical stage II, and combination chemotherapy followed by radiotherapy was initiated. During the following 5 years, the disease p...

    Authors: Inga Mandac and Slobodanka Ostojic Kolonic
    Citation: Journal of Hematology & Oncology 2010 3:20
    Content type: Letter to the Editor Published on:

  24. We have reviewed the pivotal presentations in non-small cell lung cancer (NSCLC) from the 2009 annual meeting of the American Society of Clinical Oncology. We have discussed the scientific data, the impact on ...

    Authors: Hamid R Mirshahidi and Chung T Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:18
    Content type: Review Published on:

  26. Treatment options for patients with lower risk non-del(5q) myelodysplastic syndromes (MDS) who fail erythroid stimulating agents are restricted to one of the hypomethylating drugs with an expected response rat...

    Authors: Fahd Quddus, Jessica Clima, Helen Seedham, Ghulam Sajjad, Naomi Galili and Azra Raza
    Citation: Journal of Hematology & Oncology 2010 3:16
    Content type: Case report Published on:

  27. CD7 is a negative prognostic marker in myeloid malignancies. In acute myeloid leukemia (AML), an inverse correlation exists between expression of wild-type CEBPA and CD7. Aim of this study was to find out whether...

    Authors: Sonja Röhrs, Michaela Scherr, Julia Romani, Margarete Zaborski, Hans G Drexler and Hilmar Quentmeier
    Citation: Journal of Hematology & Oncology 2010 3:15
    Content type: Research Published on:

  28. The development of Philadelphia chromosome (Ph) negative acute leukemia/myelodysplastic syndrome (MDS) in patients with Ph-positive chronic myeloid leukemia (CML) is very rare. The features of restrictive usag...

    Authors: Liang Wang, Kanger Zhu, Xianfeng Zha, Shaohua Chen, Lijian Yang, Si Chen and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2010 3:14
    Content type: Research Published on:

  29. Multiple myeloma (MM) is the second most common hematological malignancy in adults. It is characterized by clonal proliferation of terminally differentiated B lymphocytes and over-production of monoclonal immu...

    Authors: Johann Micallef, Moyez Dharsee, Jian Chen, Suzanne Ackloo, Ken Evans, Luqui Qiu and Hong Chang
    Citation: Journal of Hematology & Oncology 2010 3:13
    Content type: Review Published on:

  30. Oxaliplatin is a platinum compound used in the treatment of gastrointestinal malignancies, including colorectal cancer. The incidence of hypersensitivity reaction in patients receiving oxaliplatin is approxima...

    Authors: Marnelli A Bautista, W Tait Stevens, Chien-Shing Chen, Brian R Curtis, Richard H Aster and Chung-Tsen Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:12
    Content type: Case report Published on:

  31. We have reviewed the pivotal presentations related to gastrointestinal malignancies from 2009 annual meeting of the American Society of Clinical Oncology with the theme of "personalizing cancer care". We have ...

    Authors: Milind Javle and Chung-Tsen Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:11
    Content type: Review Published on:

  32. The ribonucleotide reductase M1 (RRM1) gene encodes the regulatory subunit of ribonucleotide reductase, the molecular target of gemcitabine. The overexpression of RRM1 mRNA in tumor tissues is reported to be a...

    Authors: Song Dong, Ai-Lin Guo, Zhi-Hong Chen, Zhen Wang, Xu-Chao Zhang, Ying Huang, Zhi Xie, Hong-Hong Yan, Hua Cheng and Yi-Long Wu
    Citation: Journal of Hematology & Oncology 2010 3:10
    Content type: Research Published on:

  33. Canfosfamide is a novel glutathione analog activated by glutathione S-transferase P1-1. This study evaluated the safety and efficacy of canfosfamide in combination with pegylated liposomal doxorubicin (PLD) in...

    Authors: John J Kavanagh, Charles F Levenback, Pedro T Ramirez, Judith L Wolf, Carla L Moore, Marsha R Jones, Lisa Meng, Gail L Brown and Robert C Bast Jr
    Citation: Journal of Hematology & Oncology 2010 3:9
    Content type: Research Published on:

  35. Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an imp...

    Authors: Bei Liu, John Nash, Carolyn Runowicz, Helen Swede, Richard Stevens and Zihai Li
    Citation: Journal of Hematology & Oncology 2010 3:7
    Content type: Review Published on:

  36. To report serial 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) tumor response following CyberKnife radiosurgery for stage IA non-small cell lung cancer (NSCLC).

    Authors: Saloomeh Vahdat, Eric K Oermann, Sean P Collins, Xia Yu, Malak Abedalthagafi, Pedro DeBrito, Simeng Suy, Shadi Yousefi, Constanza J Gutierrez, Thomas Chang, Filip Banovac, Eric D Anderson, Giuseppe Esposito and Brian T Collins
    Citation: Journal of Hematology & Oncology 2010 3:6
    Content type: Research Published on:

  37. Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and activities of transcriptional factors involved in both cancer initiation and progression through alteration of either DNA or t...

    Authors: Jiahuai Tan, Shundong Cang, Yuehua Ma, Richard L Petrillo and Delong Liu
    Citation: Journal of Hematology & Oncology 2010 3:5
    Content type: Review Published on:

  38. No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom...

    Authors: Yu Ri Seo, Se Hyung Kim, Hyun Jung Kim, Chan Kyu Kim, Seong Kyu Park, Eun Suk Koh and Dae Sik Hong
    Citation: Journal of Hematology & Oncology 2010 3:4
    Content type: Case report Published on:

  40. Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually, the sign of Leser-Trélat is associated with adenoca...

    Authors: Giovanni Ponti, Gabriele Luppi, Lorena Losi, Alberto Giannetti and Stefania Seidenari
    Citation: Journal of Hematology & Oncology 2010 3:2
    Content type: Case report Published on:

  41. Thalidomide based regimen is an effective and well tolerated therapy in multiple myeloma (MM) patients, however, there were a small number of studies written about the results of thalidomide therapy in non-tra...

    Authors: Pimjai Niparuck, Ladda Sorakhunpipitkul, Vichai Atichartakarn, Suporn Chuncharunee, Artit Ungkanont, Pantep Aungchaisuksiri, Teeraya Puavilai and Saengsuree Jootar
    Citation: Journal of Hematology & Oncology 2010 3:1
    Content type: Letter to the Editor Published on:

  42. We have described a severe combined immunodeficiency (SCID) mouse model that permits the subcutaneous growth of primary human acute leukemia blast cells into a measurable subcutaneous nodule which may be follo...

    Authors: Ying Yan, Eric A Wieman, Xiuqin Guan, Ann A Jakubowski, Peter G Steinherz and Richard J O'Reilly
    Citation: Journal of Hematology & Oncology 2009 2:51
    Content type: Research Published on:

  43. The last two decades have witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL). Development of newer treatment approaches have impro...

    Authors: Nishant Tageja, Subhash Padheye, Prasad Dandawate, Ayad Al-Katib and Ramzi M Mohammad
    Citation: Journal of Hematology & Oncology 2009 2:50
    Content type: Review Published on:

  44. The International Prognostic Index (IPI) is used to determine prognosis in diffuse large B-cell lymphoma (DLBCL). One of the determinants of IPI is the stage of disease with bone marrow involvement being class...

    Authors: Dipti Talaulikar, Bruce Shadbolt, Jane E Dahlstrom and Anne McDonald
    Citation: Journal of Hematology & Oncology 2009 2:49
    Content type: Research Published on:

  45. Pulmonary involvement and skin involvement are rare complications of plasma cell neoplasms. Here we describe what may be the first reported case of a patient with relapse in both of these sites following autol...

    Authors: Yuan Yuan, Rosemary Wieczorek, David L Green, Perry Cook, Harold Ballard and David J Araten
    Citation: Journal of Hematology & Oncology 2009 2:48
    Content type: Letter to the Editor Published on:

  46. Plasmablastic lymphoma (PL) is a subtype of diffuse large B-cell lymphoma (DLBCL). Studies have suggested that tumors with PL morphology represent a group of neoplasms with clinopathologic characteristics corr...

    Authors: Chung-Che Chang, Xiaobo Zhou, Jesalyn J Taylor, Wan-Ting Huang, Xianwen Ren, Federico Monzon, Yongdong Feng, Pulivarthi H Rao, Xin-Yan Lu, Facchetti Fabio, Susan Hilsenbeck, Chad J Creighton, Elaine S Jaffe and Ching-Ching Lau
    Citation: Journal of Hematology & Oncology 2009 2:47
    Content type: Short report Published on:

  47. Tyrosine kinase inhibitors (TKIs) like dasatinib and nilotinib are indicated as second-line treatment for chronic myeloid leukemia resistant or intolerant to the current first-line TKI imatinib. These are agen...

    Authors: David Masiello, Gerry Gorospe III and Allen S Yang
    Citation: Journal of Hematology & Oncology 2009 2:46
    Content type: Review Published on:

  49. Recent studies have suggested that the presence of iron overload prior to stem cell transplantation is associated with decreased survival. Within these studies, the criteria used to define iron overload have v...

    Authors: Jonathan A Storey, Rebecca F Connor, Zachary T Lewis, David Hurd, Gregory Pomper, Yi K Keung, Manisha Grover, James Lovato, Suzy V Torti, Frank M Torti and István Molnár
    Citation: Journal of Hematology & Oncology 2009 2:44
    Content type: Research Published on:

  50. Activated Protein C [APC] improves outcome in immunocompetent patients with severe sepsis particularly in those who are perceived to have high mortality risk. Before embarking on a trial of APC administration ...

    Authors: Rakshit Panwar, Bala Venkatesh, Peter Kruger, Robert Bird, Devinder Gill, Leo Nunnink and Goce Dimeski
    Citation: Journal of Hematology & Oncology 2009 2:43
    Content type: Research Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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