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  1. Idiopathic chronic neutropenia (ICN) describes a heterogeneous group of hematologic diseases characterized by low circulating neutrophil levels often associated with recurrent fevers, chronic mucosal inflammat...

    Authors: Roger M Lyons, Sharon T Wilks, Shelby Young and Gail L Brown
    Citation: Journal of Hematology & Oncology 2011 4:43
  2. The MRC UKALLXI trial tested the efficacy of different central nervous system (CNS) directed therapies in childhood acute lymphoblastic leukaemia (ALL). To evaluate morbidity 555/1826 randomised children under...

    Authors: Christina Halsey, Georgina Buck, Sue Richards, Faraneh Vargha-Khadem, Frank Hill and Brenda Gibson
    Citation: Journal of Hematology & Oncology 2011 4:42
  3. Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage. JAK2V617F, an activation mutation...

    Authors: Anna H Zhao, Rufei Gao and Zhizhuang J Zhao
    Citation: Journal of Hematology & Oncology 2011 4:40
  4. A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of the blast cells....

    Authors: Hilda Rachel Diamond, Maria Helena Ornellas, Alberto Orfao, Bernadete E Gomes, Mércia M Campos, Teresa S Fernandez, Roberto I da Silva, Gilda Alves, Claudia Lage, Dayse A da Silva, Arthur Moellmann-Coelho, Geydson S da Cruz, Luis Fernando Bouzas and Eliana Abdelhay
    Citation: Journal of Hematology & Oncology 2011 4:39
  5. Sall4 is a key factor for the maintenance of pluripotency and self-renewal of embryonic stem cells (ESCs). Our previous studies have shown that Sall4 is a robust stimulator for human hematopoietic stem and pro...

    Authors: Jianchang Yang, Jerell R Aguila, Zaida Alipio, Raymond Lai, Louis M Fink and Yupo Ma
    Citation: Journal of Hematology & Oncology 2011 4:38
  6. The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of myeloma (MM) cells. This study identified that microRNA-15a and -16 expressions tightly correlated with prolifer...

    Authors: Mu Hao, Li Zhang, Gang An, Weiwei Sui, Zhen Yu, Dehui Zou, Yan Xu, Hong Chang and Lugui Qiu
    Citation: Journal of Hematology & Oncology 2011 4:37
  7. Bladder cancer occurs in the majority of cases in males. It represents the seventh most common cancer and the ninth most common cause of cancer deaths for men. Transitional cell carcinoma is the most predomina...

    Authors: Nabil Ismaili, Mounia Amzerin and Aude Flechon
    Citation: Journal of Hematology & Oncology 2011 4:35
  8. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at...

    Authors: Yu Ri Kim, Jin Seok Kim, Soo Jeong Kim, Hyun Ae Jung, Seok Jin Kim, Won Seog Kim, Hye Won Lee, Hyeon Seok Eom, Seong Hyun Jeong, Joon Seong Park, June-Won Cheong and Yoo Hong Min
    Citation: Journal of Hematology & Oncology 2011 4:34
  9. The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expres...

    Authors: Yanyan Liu, Qingxin Xia, Yanzhao Jia, Hongqiang Guo, Bing Wei, Yawei Hua and Shujun Yang
    Citation: Journal of Hematology & Oncology 2011 4:33
  10. Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilo...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka and Kazuma Ohyashiki
    Citation: Journal of Hematology & Oncology 2011 4:32
  11. Pancreatic neuroendocrine tumors (NET) have diverse clinical presentations. Patients with symptoms of hormone secretion may require specific medical interventions to control those symptoms prior to antitumor i...

    Authors: Matthew H Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier and James Yao
    Citation: Journal of Hematology & Oncology 2011 4:29
  12. Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of neutrophilic granulocyte precursors, Recombinant G-CSF has been used for the treatment of congenital and ...

    Authors: Yongping Jiang, Wenhong Jiang, Yuchang Qiu and Wei Dai
    Citation: Journal of Hematology & Oncology 2011 4:28
  13. Hemangiopericytoma is a rare and aggressive meningeal tumor. Although surgical resection is the standard treatment, hemangiopericytomas often recur with high incidences of metastasis. The purpose of this study...

    Authors: Anand Veeravagu, Bowen Jiang, Chirag G Patil, Marco Lee, Scott G Soltys, Iris C Gibbs and Steven D Chang
    Citation: Journal of Hematology & Oncology 2011 4:26
  14. Although evaluation of at least 12 lymph nodes (LNs) is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate ...

    Authors: Chandrakumar Shanmugam, Robert B Hines, Nirag C Jhala, Venkat R Katkoori, Bin Zhang, James A Posey Jr, Harvey L Bumpers, William E Grizzle, Isam E Eltoum, Gene P Siegal and Upender Manne
    Citation: Journal of Hematology & Oncology 2011 4:25
  15. Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marro...

    Authors: Andrea L George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman and Raj K Tiwari
    Citation: Journal of Hematology & Oncology 2011 4:24
  16. Downregulation of the B-cell chronic lymphocytic leukemia (CLL)/lymphoma11B (BCL11B) gene by small interfering RNA (siRNA) leads to growth inhibition and apoptosis of the human T-cell acute lymphoblastic leukemia...

    Authors: Xin Huang, Qi Shen, Si Chen, Shaohua Chen, Lijian Yang, Jianyu Weng, Xin Du, Piotr Grabarczyk, Grzegorz K Przybylski, Christian A Schmidt and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:23
  17. The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis. We measured serum levels of osteopontin in 50 untreat...

    Authors: Aikaterini Sfiridaki, Spiros Miyakis, Constantina Pappa, George Tsirakis, Athanasios Alegakis, Vasileios Kotsis, Efstathios Stathopoulos and Michael Alexandrakis
    Citation: Journal of Hematology & Oncology 2011 4:22
  18. Recently, we clarified at the molecular level novel chromosomal translocation t(14;14)(q11;q32) in a case of Sézary syndrome, which caused a rearrangement from TRAJ7 to the PPP2R5C gene. PPP2R5C is one of the reg...

    Authors: Haitao Zheng, Yu Chen, Shaohua Chen, Yuzhe Niu, Lijian Yang, Bo Li, Yuhong Lu, Suxia Geng, Xin Du and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:21
  19. Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized.

    Authors: Pan Jian, Zhao Wen Li, Tao Yan Fang, Wang Jian, Zhou Zhuan, Liao Xin Mei, Wu Shui Yan and Ni Jian
    Citation: Journal of Hematology & Oncology 2011 4:20
  20. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) leads to a prolonged state of immunodeficiency and requires reconstitution of normal T-cell immunity. Signal joint T-cell receptor excision DNA ci...

    Authors: Xiuli Wu, Kanger Zhu, Xin Du, Shaohua Chen, Lijian Yang, Jufeng Wu, Qifa Liu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:19
  21. We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degr...

    Authors: Yuan Yuan, Yu-Min Liao, Chung-Tsen Hsueh and Hamid R Mirshahidi
    Citation: Journal of Hematology & Oncology 2011 4:16
  22. Endometrial carcinoma is one of the most common gynecological malignancies in women. The diagnosis of the disease at early or premalignant stages is crucial for the patient's prognosis. To date, diagnosis and ...

    Authors: Yi-sheng Wang, Rui Cao, Hong Jin, Yi-ping Huang, Xiao-yan Zhang, Qing Cong, Yi-feng He and Cong-jian Xu
    Citation: Journal of Hematology & Oncology 2011 4:15
  23. The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This confo...

    Authors: Eric K Oermann, Simeng Suy, Heather N Hanscom, Joy S Kim, Sue Lei, Xia Yu, Guowei Zhang, Brook Ennis, JoyAnn P Rohan, Nathaniel Piel, Benjamin A Sherer, Devin Borum, Viola J Chen, Gerald P Batipps, Nicholas L Constantinople, Stephen W Dejter…
    Citation: Journal of Hematology & Oncology 2011 4:12
  24. The objectives of the present study are to investigate the efficacy and safety profile of gemcitabine-based combinations in the treatment of locally advanced and metastatic pancreatic adenocarcinoma (LA/MPC).

    Authors: Jing Hu, Gang Zhao, Hong-Xia Wang, Lei Tang, Ying-Chun Xu, Yue Ma and Feng-Chun Zhang
    Citation: Journal of Hematology & Oncology 2011 4:11
  25. Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every orga...

    Authors: Gerhard J Molderings, Stefan Brettner, Jürgen Homann and Lawrence B Afrin
    Citation: Journal of Hematology & Oncology 2011 4:10
  26. Acute leukemia with coexisting Gilbert's syndrome treated by allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rarely reported. Here we described a case whose transaminase levels were almost no...

    Authors: Guo-Pan Yu, Qian-Li Jiang, Zhi-Ping Fan, Jie Zhao, Qi Wei, Jing Sun, Fan-Yi Meng and Qi-Fa Liu
    Citation: Journal of Hematology & Oncology 2011 4:9
  27. The unfolded protein response ( UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer c...

    Authors: Xuemei Li, Kezhong Zhang and Zihai Li
    Citation: Journal of Hematology & Oncology 2011 4:8
  28. BCR-ABL kinase domain (KD) mutation is the major mechanism contributing to suboptimal response to tyrosine kinase inhibitors (TKI) in BCR-ABL-positive chronic myeloid leukemia (CML) patients. T315I mutation, as o...

    Authors: Wanwisa Wongboonma, Wanna Thongnoppakhun and Chirayu U Auewarakul
    Citation: Journal of Hematology & Oncology 2011 4:7
  29. The BCR-ABL1 translocation occurs in chronic myeloid leukemia (CML) and in 25% of cases with acute lymphoblastic leukemia (ALL). The advent of tyrosine kinase inhibitors (TKI) has fundamentally changed the treatm...

    Authors: Hilmar Quentmeier, Sonja Eberth, Julia Romani, Margarete Zaborski and Hans G Drexler
    Citation: Journal of Hematology & Oncology 2011 4:6
  30. Chemotherapy combined concurrently with TKIs produced a negative interaction and failed to improve survival when compared with chemotherapy or TKIs alone in the treatment of non-small cell lung cancer (NSCLC)....

    Authors: Hua Cheng, She-Juan An, Song Dong, Yi-Fang Zhang, Xu-Chao Zhang, Zhi-Hong Chen, Jian-Su and Yi-Long Wu
    Citation: Journal of Hematology & Oncology 2011 4:5
  31. JAK2V617F is found in the majority of patients with Ph- myeloproliferative neoplasms (MPNs) and has become a valuable marker for diagnosis of MPNs. However, it has also been found in many other hematological d...

    Authors: Wanming Zhao, Rufei Gao, Jiyun Lee, Shu Xing, Wanting T Ho, Xueqi Fu, Shibo Li and Zhizhuang J Zhao
    Citation: Journal of Hematology & Oncology 2011 4:4
  32. This phase I, randomized, multicenter, open-label study investigated the pharmacokinetics, safety, and efficacy of the oral mammalian target of rapamycin inhibitor everolimus in Chinese patients with advanced ...

    Authors: BingHe Xu, YiLong Wu, Lin Shen, DingWei Ye, Annette Jappe, Azzeddine Cherfi, Hui Wang and RuiRong Yuan
    Citation: Journal of Hematology & Oncology 2011 4:3
  33. Our previous study had amplified antigen-specific full-length TCR α and β genes of clonally expanded T cells in the peripheral blood (PB) of patients with diffuse large B-cell lymphoma (DLBCL). The transfer of...

    Authors: Qingsong Yin, Xianfeng Zha, Lijian Yang, Shaohua Chen, Yubing Zhou, Xiuli Wu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:2
  34. Myelodysplastic syndrome with isolated chromosome 5q deletion (5q- syndrome) is a clonal stem cell disorder characterized by ineffective hematopoiesis. MicroRNAs (miRNAs) are important regulators of hematopoie...

    Authors: Hana Votavova, Martina Grmanova, Michaela Dostalova Merkerova, Monika Belickova, Alzbeta Vasikova, Radana Neuwirtova and Jaroslav Cermak
    Citation: Journal of Hematology & Oncology 2011 4:1
  35. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the ea...

    Authors: Sun Zi-Min, Liu Hui-Lan, Geng Liang-Quan, Wang Xin-Bing, Yao Wen, Liu Xin, Ding Kai-Yang, Han Yong-Sheng, Yang Hui-Zhi, Tang Bo-lin, Tong Juan, Zhu Wei-Bo and Wang Zu-Yi
    Citation: Journal of Hematology & Oncology 2010 3:51
  36. Zearalenone (ZEA) is a phytoestrogen from Fusarium species. The aims of the study was to identify mode of human leukemic cell death induced by ZEA and the mechanisms involved.

    Authors: Ratana Banjerdpongchai, Prachya Kongtawelert, Orawan Khantamat, Chantragan Srisomsap, Daranee Chokchaichamnankit, Pantipa Subhasitanont and Jisnuson Svasti
    Citation: Journal of Hematology & Oncology 2010 3:50
  37. We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphoc...

    Authors: Séverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, Jean-Pierre Kolb and Christian Billard
    Citation: Journal of Hematology & Oncology 2010 3:49
  38. We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells ...

    Authors: Shaohong Jiang, Xudong Ma, Yiqun Huang, Yunlu Xu, Ruiji Zheng and Jen-Wei Chiao
    Citation: Journal of Hematology & Oncology 2010 3:48
  39. Recent reports indicate that microRNAs (miRNAs) play a critical role in malignancies. However, the role that miRNAs play in pancreatic cancer remains to be determined. The purpose of this study was to investig...

    Authors: Xing J Zhang, Hua Ye, Cheng W Zeng, Bo He, Hua Zhang and Yue Q Chen
    Citation: Journal of Hematology & Oncology 2010 3:46
  40. Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenes...

    Authors: Patrick B Johnston, RuiRong Yuan, Franco Cavalli and Thomas E Witzig
    Citation: Journal of Hematology & Oncology 2010 3:45

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