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  1. Recently, we clarified at the molecular level novel chromosomal translocation t(14;14)(q11;q32) in a case of Sézary syndrome, which caused a rearrangement from TRAJ7 to the PPP2R5C gene. PPP2R5C is one of the reg...

    Authors: Haitao Zheng, Yu Chen, Shaohua Chen, Yuzhe Niu, Lijian Yang, Bo Li, Yuhong Lu, Suxia Geng, Xin Du and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:21
    Content type: Short report Published on:

  2. Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized.

    Authors: Pan Jian, Zhao Wen Li, Tao Yan Fang, Wang Jian, Zhou Zhuan, Liao Xin Mei, Wu Shui Yan and Ni Jian
    Citation: Journal of Hematology & Oncology 2011 4:20
    Content type: Research Published on:

  3. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) leads to a prolonged state of immunodeficiency and requires reconstitution of normal T-cell immunity. Signal joint T-cell receptor excision DNA ci...

    Authors: Xiuli Wu, Kanger Zhu, Xin Du, Shaohua Chen, Lijian Yang, Jufeng Wu, Qifa Liu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:19
    Content type: Research Published on:

  6. We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degr...

    Authors: Yuan Yuan, Yu-Min Liao, Chung-Tsen Hsueh and Hamid R Mirshahidi
    Citation: Journal of Hematology & Oncology 2011 4:16
    Content type: Review Published on:

  7. Endometrial carcinoma is one of the most common gynecological malignancies in women. The diagnosis of the disease at early or premalignant stages is crucial for the patient's prognosis. To date, diagnosis and ...

    Authors: Yi-sheng Wang, Rui Cao, Hong Jin, Yi-ping Huang, Xiao-yan Zhang, Qing Cong, Yi-feng He and Cong-jian Xu
    Citation: Journal of Hematology & Oncology 2011 4:15
    Content type: Short report Published on:

  10. The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This confo...

    Authors: Eric K Oermann, Simeng Suy, Heather N Hanscom, Joy S Kim, Sue Lei, Xia Yu, Guowei Zhang, Brook Ennis, JoyAnn P Rohan, Nathaniel Piel, Benjamin A Sherer, Devin Borum, Viola J Chen, Gerald P Batipps, Nicholas L Constantinople, Stephen W Dejter…
    Citation: Journal of Hematology & Oncology 2011 4:12
    Content type: Research Published on:

  11. The objectives of the present study are to investigate the efficacy and safety profile of gemcitabine-based combinations in the treatment of locally advanced and metastatic pancreatic adenocarcinoma (LA/MPC).

    Authors: Jing Hu, Gang Zhao, Hong-Xia Wang, Lei Tang, Ying-Chun Xu, Yue Ma and Feng-Chun Zhang
    Citation: Journal of Hematology & Oncology 2011 4:11
    Content type: Research Published on:

  12. Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every orga...

    Authors: Gerhard J Molderings, Stefan Brettner, Jürgen Homann and Lawrence B Afrin
    Citation: Journal of Hematology & Oncology 2011 4:10
    Content type: Review Published on:

  13. Acute leukemia with coexisting Gilbert's syndrome treated by allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rarely reported. Here we described a case whose transaminase levels were almost no...

    Authors: Guo-Pan Yu, Qian-Li Jiang, Zhi-Ping Fan, Jie Zhao, Qi Wei, Jing Sun, Fan-Yi Meng and Qi-Fa Liu
    Citation: Journal of Hematology & Oncology 2011 4:9
    Content type: Letter to the Editor Published on:

  14. The unfolded protein response ( UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer c...

    Authors: Xuemei Li, Kezhong Zhang and Zihai Li
    Citation: Journal of Hematology & Oncology 2011 4:8
    Content type: Review Published on:

  15. BCR-ABL kinase domain (KD) mutation is the major mechanism contributing to suboptimal response to tyrosine kinase inhibitors (TKI) in BCR-ABL-positive chronic myeloid leukemia (CML) patients. T315I mutation, as o...

    Authors: Wanwisa Wongboonma, Wanna Thongnoppakhun and Chirayu U Auewarakul
    Citation: Journal of Hematology & Oncology 2011 4:7
    Content type: Research Published on:

  16. The BCR-ABL1 translocation occurs in chronic myeloid leukemia (CML) and in 25% of cases with acute lymphoblastic leukemia (ALL). The advent of tyrosine kinase inhibitors (TKI) has fundamentally changed the treatm...

    Authors: Hilmar Quentmeier, Sonja Eberth, Julia Romani, Margarete Zaborski and Hans G Drexler
    Citation: Journal of Hematology & Oncology 2011 4:6
    Content type: Research Published on:

  17. Chemotherapy combined concurrently with TKIs produced a negative interaction and failed to improve survival when compared with chemotherapy or TKIs alone in the treatment of non-small cell lung cancer (NSCLC)....

    Authors: Hua Cheng, She-Juan An, Song Dong, Yi-Fang Zhang, Xu-Chao Zhang, Zhi-Hong Chen, Jian-Su and Yi-Long Wu
    Citation: Journal of Hematology & Oncology 2011 4:5
    Content type: Research Published on:

  18. JAK2V617F is found in the majority of patients with Ph- myeloproliferative neoplasms (MPNs) and has become a valuable marker for diagnosis of MPNs. However, it has also been found in many other hematological d...

    Authors: Wanming Zhao, Rufei Gao, Jiyun Lee, Shu Xing, Wanting T Ho, Xueqi Fu, Shibo Li and Zhizhuang J Zhao
    Citation: Journal of Hematology & Oncology 2011 4:4
    Content type: Short report Published on:

  19. This phase I, randomized, multicenter, open-label study investigated the pharmacokinetics, safety, and efficacy of the oral mammalian target of rapamycin inhibitor everolimus in Chinese patients with advanced ...

    Authors: BingHe Xu, YiLong Wu, Lin Shen, DingWei Ye, Annette Jappe, Azzeddine Cherfi, Hui Wang and RuiRong Yuan
    Citation: Journal of Hematology & Oncology 2011 4:3
    Content type: Research Published on:

  20. Our previous study had amplified antigen-specific full-length TCR α and β genes of clonally expanded T cells in the peripheral blood (PB) of patients with diffuse large B-cell lymphoma (DLBCL). The transfer of...

    Authors: Qingsong Yin, Xianfeng Zha, Lijian Yang, Shaohua Chen, Yubing Zhou, Xiuli Wu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:2
    Content type: Research Published on:

  21. Myelodysplastic syndrome with isolated chromosome 5q deletion (5q- syndrome) is a clonal stem cell disorder characterized by ineffective hematopoiesis. MicroRNAs (miRNAs) are important regulators of hematopoie...

    Authors: Hana Votavova, Martina Grmanova, Michaela Dostalova Merkerova, Monika Belickova, Alzbeta Vasikova, Radana Neuwirtova and Jaroslav Cermak
    Citation: Journal of Hematology & Oncology 2011 4:1
    Content type: Short report Published on:

  22. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the ea...

    Authors: Sun Zi-Min, Liu Hui-Lan, Geng Liang-Quan, Wang Xin-Bing, Yao Wen, Liu Xin, Ding Kai-Yang, Han Yong-Sheng, Yang Hui-Zhi, Tang Bo-lin, Tong Juan, Zhu Wei-Bo and Wang Zu-Yi
    Citation: Journal of Hematology & Oncology 2010 3:51
    Content type: Letter to the Editor Published on:

  23. Zearalenone (ZEA) is a phytoestrogen from Fusarium species. The aims of the study was to identify mode of human leukemic cell death induced by ZEA and the mechanisms involved.

    Authors: Ratana Banjerdpongchai, Prachya Kongtawelert, Orawan Khantamat, Chantragan Srisomsap, Daranee Chokchaichamnankit, Pantipa Subhasitanont and Jisnuson Svasti
    Citation: Journal of Hematology & Oncology 2010 3:50
    Content type: Research Published on:

  24. We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphoc...

    Authors: Séverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, Jean-Pierre Kolb and Christian Billard
    Citation: Journal of Hematology & Oncology 2010 3:49
    Content type: Letter to the Editor Published on:

  25. We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells ...

    Authors: Shaohong Jiang, Xudong Ma, Yiqun Huang, Yunlu Xu, Ruiji Zheng and Jen-Wei Chiao
    Citation: Journal of Hematology & Oncology 2010 3:48
    Content type: Research Published on:

  27. Recent reports indicate that microRNAs (miRNAs) play a critical role in malignancies. However, the role that miRNAs play in pancreatic cancer remains to be determined. The purpose of this study was to investig...

    Authors: Xing J Zhang, Hua Ye, Cheng W Zeng, Bo He, Hua Zhang and Yue Q Chen
    Citation: Journal of Hematology & Oncology 2010 3:46
    Content type: Research Published on:

  28. Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenes...

    Authors: Patrick B Johnston, RuiRong Yuan, Franco Cavalli and Thomas E Witzig
    Citation: Journal of Hematology & Oncology 2010 3:45
    Content type: Review Published on:

  29. In a human T-cell acute lymphoblastic leukemia (T-ALL) cell line (Molt-4), siRNA-mediated suppression of BCL11B expression was shown to inhibit proliferation and induce apoptosis, functions which may be related t...

    Authors: Xin Huang, Shaohua Chen, Qi Shen, Lijian Yang, Bo Li, Liye Zhong, Suxia Geng, Xin Du and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2010 3:44
    Content type: Research Published on:

  30. Hepatocellular carcinoma (HCC) still is a big burden for China. In recent years, the third-generation platinum compounds have been proposed as potential active agents for HCC. However, more experimental and cl...

    Authors: Qiong Wu, Shu-Kui Qin, Feng-Meng Teng, Chang-Jie Chen and Rui Wang
    Citation: Journal of Hematology & Oncology 2010 3:43
    Content type: Research Published on:

  31. Breast cancer is a heterogeneous disease composed of different subtypes, characterized by their different clinicopathological characteristics, prognoses and responses to treatment. In the past decade, signific...

    Authors: Rafael Santana-Davila and Edith A Perez
    Citation: Journal of Hematology & Oncology 2010 3:42
    Content type: Review Published on:

  32. Mutations in the nucleophosmin (NPM1) gene have been solely associated with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 mutations in childhood AML, their relation to clinical and cy...

    Authors: Maria Braoudaki, Chrissa Papathanassiou, Katerina Katsibardi, Natalia Tourkadoni, Kalliopi Karamolegou and Fotini Tzortzatou-Stathopoulou
    Citation: Journal of Hematology & Oncology 2010 3:41
    Content type: Research Published on:

  33. Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER para...

    Authors: Saad Z Usmani, Robert D Bona, Gabriela Chiosis and Zihai Li
    Citation: Journal of Hematology & Oncology 2010 3:40
    Content type: Research Published on:

  34. To report clinical efficacy and toxicity of fractionated CyberKnife radiosurgery for the treatment of hilar lung tumors.

    Authors: Keith Unger, Andrew Ju, Eric Oermann, Simeng Suy, Xia Yu, Saloomeh Vahdat, Deepa Subramaniam, K William Harter, Sean P Collins, Anatoly Dritschilo, Eric Anderson and Brian T Collins
    Citation: Journal of Hematology & Oncology 2010 3:39
    Content type: Short report Published on:

  35. Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences...

    Authors: Antonio Sacco, Ghayas C Issa, Yong Zhang, Yang Liu, Patricia Maiso, Irene M Ghobrial and Aldo M Roccaro
    Citation: Journal of Hematology & Oncology 2010 3:38
    Content type: Review Published on:

  36. MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features rela...

    Authors: Anuradha Budhu, Junfang Ji and Xin W Wang
    Citation: Journal of Hematology & Oncology 2010 3:37
    Content type: Review Published on:

  37. Optimal conditioning therapy for hematopoietic cell transplantation (HCT) in acute myelogenous leukemia (AML) remains undefined. We retrospectively compared outcomes of a consecutive series of 51 AML patients ...

    Authors: Joseph Pidala, Jongphil Kim, Claudio Anasetti, Mohamed A Kharfan-Dabaja, Taiga Nishihori, Teresa Field, Janelle Perkins, Lia Perez and Hugo F Fernandez
    Citation: Journal of Hematology & Oncology 2010 3:36
    Content type: Research Published on:

  39. Mantle cell lymphoma is a lymphoid entity characterized by adenopathy, blood and bone marrow involment which only recurrent mucosal localisation is the lymphomatoid polyposis. Few other mucosal infiltrations h...

    Authors: Jean-Christophe Ianotto, Adrian Tempescul, Jean-Richard Eveillard, Norbert André, Frederic Morel, Isabelle Quintin-Roué and Christian Berthou
    Citation: Journal of Hematology & Oncology 2010 3:34
    Content type: Letter to the Editor Published on:

  40. Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the patho...

    Authors: Xueling GE and Xin Wang
    Citation: Journal of Hematology & Oncology 2010 3:33
    Content type: Review Published on:

  41. We describe a case of multiple myeloma (MM) and secondary plasma cell leukemia (PCL) secreting IgE-kappa immunoglobulin. To our knowledge, only 2 cases of IgE-producing secondary PCL have been reported in the ...

    Authors: Giampaolo Talamo, William Castellani and Nathan G Dolloff
    Citation: Journal of Hematology & Oncology 2010 3:32
    Content type: Case report Published on:

  42. We report a 49-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with trastuzumab-containing regimen. He underwent esoph...

    Authors: Jun Wang, George W Saukel, Carlos A Garberoglio, Wichit Srikureja and Chung-Tsen Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:31
    Content type: Case report Published on:

  43. Mantle cell lymphoma (MCL) is a rare and aggressive type of B-cell non-Hodgkin's lymphoma. Patients become progressively refractory to conventional chemotherapy, and their prognosis is poor. However, a 38% rem...

    Authors: Li Wang, Wen-Yu Shi, Zhi-Yuan Wu, Mariana Varna, Ai-Hua Wang, Li Zhou, Li Chen, Zhi-Xiang Shen, He Lu, Wei-Li Zhao and Anne Janin
    Citation: Journal of Hematology & Oncology 2010 3:30
    Content type: Case report Published on:

  44. The Gγ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about Gγ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This stud...

    Authors: Rong Rong Liu, Ming Yue Wang and Yong Rong Lai
    Citation: Journal of Hematology & Oncology 2010 3:29
    Content type: Letter to the Editor Published on:

  45. Acute promyelocytic leukemia (APL) is a blood cancer that affects people of all ages and strikes about 1,500 patients in the United States each year. The standard treatment of APL has been based on the combine...

    Authors: Clement Yedjou, Paul Tchounwou, John Jenkins and Robert McMurray
    Citation: Journal of Hematology & Oncology 2010 3:28
    Content type: Research Published on:

  46. In newly diagnosed patients with Hodgkin lymphoma (HL) the effect of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD)-related neutropenia on chemotherapy delivery is poorly documented. The aim of thi...

    Authors: Matthias Schwenkglenks, Ruth Pettengell, Thomas D Szucs, Eva Culakova and Gary H Lyman
    Citation: Journal of Hematology & Oncology 2010 3:27
    Content type: Short report Published on:

  47. Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplast...

    Authors: Clara Hwang and Elisabeth I Heath
    Citation: Journal of Hematology & Oncology 2010 3:26
    Content type: Review Published on:

  48. The ring chromosome is a circular, structural abnormality composed of either multiple chromosomes or a single chromosome with loss of genetic material at one or both ends. This chromosomal rearrangement is oft...

    Authors: Shanthi Sivendran, Stephen Gruenstein, Adriana K Malone and Vesna Najfeld
    Citation: Journal of Hematology & Oncology 2010 3:25
    Content type: Case report Published on:

  49. We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subseq...

    Authors: Marnelli A Bautista-Quach, Yu-Min Liao and Chung-Tsen Hsueh
    Citation: Journal of Hematology & Oncology 2010 3:24
    Content type: Case report Published on:

  50. Management of localized primary gastric B lymphoma (PGL) remains controversial. The aim of this study is to compare two treatments: chemotherapy alone and surgery plus chemotherapy.

    Authors: Yassir Sbitti, Nabil Ismaili, Youssef Bensouda, Habiba Kadiri, Mohammed Ichou and Hassan Errihani
    Citation: Journal of Hematology & Oncology 2010 3:23
    Content type: Short report Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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