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  1. Content type: Research

    JS001, a humanized IgG4 monoclonal antibody against the programmed death-1 (PD-1) receptor, blocks the interaction of PD-1 with its ligands and promotes T cell activation in preclinical studies. This phase I stud...

    Authors: Bixia Tang, Xieqiao Yan, Xinan Sheng, Lu Si, Chuanliang Cui, Yan Kong, Lili Mao, Bin Lian, Xue Bai, Xuan Wang, Siming Li, Li Zhou, Jiayi Yu, Jie Dai, Kai Wang, Jinwei Hu…

    Citation: Journal of Hematology & Oncology 2019 12:7

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  2. Content type: Research

    There is a paucity of data on the role of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with angioimmunoblastic T-cell lymphoma (AITL). Using the CIBMTR registry, we report here the outc...

    Authors: Narendranath Epperla, Kwang W. Ahn, Carlos Litovich, Sairah Ahmed, Minoo Battiwalla, Jonathon B. Cohen, Parastoo Dahi, Nosha Farhadfar, Umar Farooq, Cesar O. Freytes, Nilanjan Ghosh, Bradley Haverkos, Alex Herrera, Mark Hertzberg, Gerhard Hildebrandt, David Inwards…

    Citation: Journal of Hematology & Oncology 2019 12:6

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  3. Content type: Research

    Several new drugs are approved for treatment of patients with multiple myeloma (MM), but no validated biomarkers are available for the prediction of a clinical outcome. We aimed to establish whether pretreatme...

    Authors: Ilaria Saltarella, Fortunato Morabito, Nicola Giuliani, Carolina Terragna, Paola Omedè, Antonio Palumbo, Sara Bringhen, Lorenzo De Paoli, Enrica Martino, Alessandra Larocca, Massimo Offidani, Francesca Patriarca, Chiara Nozzoli, Tommasina Guglielmelli, Giulia Benevolo, Vincenzo Callea…

    Citation: Journal of Hematology & Oncology 2019 12:4

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  4. Content type: Research

    Abnormal expression of long non-coding RNAs (lncRNAs) has been found in almost all human tumors, providing numerous potential diagnostic biomarkers, prognostic biomarkers, and therapeutic targets.

    Authors: Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Xueni Xu, Bei Pan, Tao Xu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang

    Citation: Journal of Hematology & Oncology 2019 12:3

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  5. Content type: Research

    Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlyi...

    Authors: Stefania Raimondo, Laura Saieva, Emanuela Vicario, Marzia Pucci, Denise Toscani, Mauro Manno, Samuele Raccosta, Nicola Giuliani and Riccardo Alessandro

    Citation: Journal of Hematology & Oncology 2019 12:2

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  6. Content type: Research

    Patients with CML treated with TKI can have a life expectancy comparable to that of the general population. Due to the extended duration of TKI administration, treatment discontinuation has been increasingly s...

    Authors: Kamal Chamoun, Hagop Kantarjian, Rami Atallah, Graciela Nogueras Gonzalez, Ghayas C. Issa, Mary Beth Rios, Guillermo Garcia-Manero, Gautam Borthakur, Farhad Ravandi, Nitin Jain, Naval Daver, Marina Konopleva, Courtney D. DiNardo, Tapan Kadia, Naveen Pemmaraju, Elias Jabbour…

    Citation: Journal of Hematology & Oncology 2019 12:1

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  7. Content type: Review

    Bosutinib, a BCR-ABL1 tyrosine kinase inhibitor (TKI), has been available for several years as a treatment for chronic-, accelerated-, and blast-phase chronic myeloid leukemia (CML), for patients with resistan...

    Authors: Jorge E. Cortes, Jane F. Apperley, Daniel J. DeAngelo, Michael W. Deininger, Vamsi K. Kota, Philippe Rousselot and Carlo Gambacorti-Passerini

    Citation: Journal of Hematology & Oncology 2018 11:143

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  8. Content type: Review

    The immune system is the hard-wired host defense mechanism against pathogens as well as cancer. Five years ago, we pondered the question if the era of cancer immunotherapy was upon us (Li et al., Exp Hem Oncol...

    Authors: Zihai Li, Wenru Song, Mark Rubinstein and Delong Liu

    Citation: Journal of Hematology & Oncology 2018 11:142

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  9. Content type: Research

    Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a dual epitope-binding CAR T cell therapy directe...

    Authors: Wan-Hong Zhao, Jie Liu, Bai-Yan Wang, Yin-Xia Chen, Xing-Mei Cao, Yun Yang, Yi-Lin Zhang, Fang-Xia Wang, Peng-Yu Zhang, Bo Lei, Liu-Fang Gu, Jian-Li Wang, Nan Yang, Ru Zhang, Hui Zhang, Ying Shen…

    Citation: Journal of Hematology & Oncology 2018 11:141

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  10. Content type: Research

    The study aims to present the effect of PIK3CA E542K and E545K mutations on glucose metabolism and proliferation and identify their underlying mechanisms in cervical cancer.

    Authors: Wei Jiang, Tiancong He, Shuai Liu, Yingying Zheng, Libing Xiang, Xuan Pei, Ziliang Wang and Huijuan Yang

    Citation: Journal of Hematology & Oncology 2018 11:139

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  11. Content type: Research

    There is no convincing data on the trends of hospitalizations, mortality, cost, and demographic variations associated with inpatient admissions for gastric cancer in the USA. The aim of this study was to use a...

    Authors: Delong Liu, Dhruv Mehta, Supreet Kaur, Arun Kumar, Kaushal Parikh, Lavneet Chawla, Shanti Patel, Amirta Devi and Aparna Saha

    Citation: Journal of Hematology & Oncology 2018 11:138

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  12. Content type: Research

    Human myeloma cell lines (HMCLs) are widely used for their representation of primary myeloma cells because they cover patient diversity, although not fully. Their genetic background is mostly undiscovered, and...

    Authors: Benoît Tessoulin, Agnès Moreau-Aubry, Géraldine Descamps, Patricia Gomez-Bougie, Sophie Maïga, Alban Gaignard, David Chiron, Emmanuelle Ménoret, Steven Le Gouill, Philippe Moreau, Martine Amiot and Catherine Pellat-Deceunynck

    Citation: Journal of Hematology & Oncology 2018 11:137

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  13. Content type: Review

    Precision radiotherapy, which accurately delivers the dose on a tumor and confers little or no irradiation to the surrounding normal tissue and organs, results in maximum tumor control and decreases the toxici...

    Authors: Man Hu, Liyang Jiang, Xiangli Cui, Jianguang Zhang and Jinming Yu

    Citation: Journal of Hematology & Oncology 2018 11:136

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  14. Content type: Research

    Mesenchymal stromal cells (MSCs) are a promising therapy for preventing chronic Graft-Versus-Host Disease (cGVHD) due to their potent immunomodulatory properties. However, the safety concerns regarding the use...

    Authors: Peilong Lai, Xiaomei Chen, Liyan Guo, Yulian Wang, Xialin Liu, Yan Liu, Tian Zhou, Tian Huang, Suxia Geng, Chengwei Luo, Xin Huang, Suijing Wu, Wei Ling, Xin Du, Chang He and Jianyu Weng

    Citation: Journal of Hematology & Oncology 2018 11:135

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  15. Content type: Review

    Natural-killer/T cell lymphoma (NKTCL) represents the most common subtype of extranodal lymphoma with aggressive clinical behavior. Prevalent in Asians and South Americans, the pathogenesis of NKTCL remains to...

    Authors: Jie Xiong and Wei-Li Zhao

    Citation: Journal of Hematology & Oncology 2018 11:134

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  16. Content type: Review

    FLT3 mutations are one of the most common findings in acute myeloid leukemia (AML). FLT3 inhibitors have been in active clinical development. Midostaurin as the first-in-class FLT3 inhibitor has been approved ...

    Authors: Mei Wu, Chuntuan Li and Xiongpeng Zhu

    Citation: Journal of Hematology & Oncology 2018 11:133

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  17. Content type: Review

    Currently, the two approved T cell products with chimeric antigen receptors (CAR) are from autologous T cells. These CAR T cells approved for clinical use must be generated on a custom-made basis. This case-by...

    Authors: Juanjuan Zhao, Quande Lin, Yongping Song and Delong Liu

    Citation: Journal of Hematology & Oncology 2018 11:132

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  18. Content type: Review

    Recent studies have revealed that non-coding regions comprise the vast majority of the human genome and long non-coding RNAs (lncRNAs) are a diverse class of non-coding RNAs that has been implicated in a varie...

    Authors: Nonthaphat Kent Wong, Chien-Ling Huang, Rashidul Islam and Shea Ping Yip

    Citation: Journal of Hematology & Oncology 2018 11:131

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  19. Content type: Research

    This retrospective study was undertaken to determine if the plasma circulating tumor DNA (ctDNA) level and tumor biological features in patients with advanced solid tumors affected the detection of genomic alt...

    Authors: Cathy Zhou, Zilong Yuan, Weijie Ma, Lihong Qi, Angelique Mahavongtrakul, Ying Li, Hong Li, Jay Gong, Reggie R. Fan, Jin Li, Michael Molmen, Travis A. Clark, Dean Pavlick, Garrett M. Frampton, Brady Forcier, Elizabeth H. Moore…

    Citation: Journal of Hematology & Oncology 2018 11:129

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  20. Content type: Case report

    POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome still has no standard treatment. On the basis that both POEMS syndrome and myeloma have an underlying plas...

    Authors: Jinhuan Xu, Qiuxiang Wang, Hao Xu, Chaojiang Gu, Lijun Jiang, Jue Wang, Di Wang, Bin Xu, Xia Mao, Jin Wang, Zhiqiong Wang, Yi Xiao, Yicheng Zhang, Chunrui Li and Jianfeng Zhou

    Citation: Journal of Hematology & Oncology 2018 11:128

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  21. Content type: Research

    Graft-versus-host disease (GVHD) is one of the leading causes of non-relapse mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HCT).

    Authors: Florent Malard, Myriam Labopin, Christina Cho, Didier Blaise, Esperanza B. Papadopoulos, Jakob Passweg, Richard O’Reilly, Edouard Forcade, Molly Maloy, Liisa Volin, Hugo Castro-Malaspina, Yosr Hicheri, Ann A. Jakubowski, Corentin Orvain, Sergio Giralt, Mohamad Mohty…

    Citation: Journal of Hematology & Oncology 2018 11:127

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  22. Content type: Review

    Hepatocellular carcinoma (HCC) is one of the most common tumors in the world, and its mortality is still on the rise. Limited treatments and low chemotherapy sensitivity of HCC make new therapeutic strategies ...

    Authors: Feifei Liu, Yanning Liu and Zhi Chen

    Citation: Journal of Hematology & Oncology 2018 11:126

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  23. Content type: Research

    Postmenopausal women with large, hormone receptor (HR)-positive/HER2-negative and low-proliferative breast cancer derived a benefit from neoadjuvant endocrine therapy (NET) in the CARMINA02 trial. This study w...

    Authors: Xu Liang, Adrien Briaux, Véronique Becette, Camille Benoist, Anais Boulai, Walid Chemlali, Anne Schnitzler, Sylvain Baulande, Sofia Rivera, Marie-Ange Mouret-Reynier, Laurence Venat Bouvet, Thibaut De La Motte Rouge, Jérôme Lemonnier, Florence Lerebours and Céline Callens

    Citation: Journal of Hematology & Oncology 2018 11:124

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  24. Content type: Research

    In spite of major advances in treatment, multiple myeloma (MM) is currently an incurable malignancy due to the emergence of drug-resistant clones. We previously showed that MM cells upregulate the transcriptio...

    Authors: Daniela N Petrusca, Denise Toscani, Feng-Ming Wang, Cheolkyu Park, Colin D Crean, Judith L Anderson, Silvia Marino, Khalid S Mohammad, Dan Zhou, Rebecca Silbermann, Quanhong Sun, Noriyoshi Kurihara, Deborah L Galson, Nicola Giuliani and G David Roodman

    Citation: Journal of Hematology & Oncology 2018 11:123

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  25. Content type: Letter to the Editor

    The JAK inhibitor (JAKi) ruxolitinib is standard treatment for myelofibrosis (MF), but some patients are unresponsive. Pre-clinical and clinical data suggest that addition of a Hedgehog pathway inhibitor (HPI)...

    Authors: Stephen Couban, Giulia Benevolo, William Donnellan, Jennifer Cultrera, Steffen Koschmieder, Srdan Verstovsek, Gregory Hooper, Christian Hertig, Maneesh Tandon, Natalie Dimier, Vikram Malhi and Francesco Passamonti

    Citation: Journal of Hematology & Oncology 2018 11:122

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  26. Content type: Review

    Genetically modified T cells that express a chimeric antigen receptor (CAR) are opening a new frontier in cancer immunotherapy. CAR T cells currently are in clinical trials for many cancer types. Cytokine rele...

    Authors: Delong Liu and Juanjuan Zhao

    Citation: Journal of Hematology & Oncology 2018 11:121

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  27. Content type: Review

    Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor rece...

    Authors: Guoshuang Shen, Fangchao Zheng, Dengfeng Ren, Feng Du, Qiuxia Dong, Ziyi Wang, Fuxing Zhao, Raees Ahmad and Jiuda Zhao

    Citation: Journal of Hematology & Oncology 2018 11:120

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  28. Content type: Research

    HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively act...

    Authors: Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz and Christophe Nicot

    Citation: Journal of Hematology & Oncology 2018 11:119

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  29. Content type: Review

    Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in th...

    Authors: Min Su, Yuhang Xiao, Junliang Ma, Deliang Cao, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang

    Citation: Journal of Hematology & Oncology 2018 11:118

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  30. Content type: Research

    Platelet glycoprotein Ibα (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in ...

    Authors: Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu and Xin Liang

    Citation: Journal of Hematology & Oncology 2018 11:117

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  31. Content type: Review

    During the past decade, the three-dimensional organoid technology has sprung up and become more and more popular among researchers. Organoids are the miniatures of in vivo tissues and organs, and faithfully re...

    Authors: Hanxiao Xu, Xiaodong Lyu, Ming Yi, Weiheng Zhao, Yongping Song and Kongming Wu

    Citation: Journal of Hematology & Oncology 2018 11:116

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  32. Content type: Research

    Recently, many potential prognostic biomarkers for gastric cancer (GC) have been identified, but the prognosis of advanced GC patients remains poor. Chloride channels are promising cancer biomarkers, and their...

    Authors: Zhuoyu Gu, Yixin Li, Xiaoya Yang, Meisheng Yu, Zhanru Chen, Chan Zhao, Lixin Chen and Liwei Wang

    Citation: Journal of Hematology & Oncology 2018 11:115

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  33. Content type: Letter to the Editor

    Distant metastasis is initiated by circulating tumor cells (CTCs), which are considered to be a determining factor for the degree of metastasis and the survival of cancer patients. Although CTC-based diagnosti...

    Authors: Yi Rang Kim, Jung Ki Yoo, Chang Wook Jeong and Jin Woo Choi

    Citation: Journal of Hematology & Oncology 2018 11:114

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    The Correction to this article has been published in Journal of Hematology & Oncology 2019 12:5

  34. Content type: Research

    The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been reported to be overexpressed in colorectal cancer (CRC). However, its underlying mechanisms in the progression of CRC have not bee...

    Authors: Meng Zhang, Weiwei Weng, Qiongyan Zhang, Yong Wu, Shujuan Ni, Cong Tan, Midie Xu, Hui Sun, Chenchen Liu, Ping Wei and Xiang Du

    Citation: Journal of Hematology & Oncology 2018 11:113

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  35. Content type: Research

    Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such ...

    Authors: Simon Heine, Markus Kleih, Neus Giménez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip and Elisabeth Silkenstedt

    Citation: Journal of Hematology & Oncology 2018 11:112

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  36. Content type: Review

    Histone acetylation and deacetylation are important epigenetic mechanisms that regulate gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only part...

    Authors: Ting Li, Chao Zhang, Shafat Hassan, Xinyue Liu, Fengju Song, Kexin Chen, Wei Zhang and Jilong Yang

    Citation: Journal of Hematology & Oncology 2018 11:111

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  37. Content type: Research

    Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploide...

    Authors: Federica Giannotti, Myriam Labopin, Roni Shouval, Jaime Sanz, William Arcese, Emanuele Angelucci, Jorge Sierra, Josep-Maria Ribera Santasusana, Stella Santarone, Bruno Benedetto, Alessandro Rambaldi, Riccardo Saccardi, Didier Blaise, Michele Angelo Carella, Vanderson Rocha, Frederic Baron…

    Citation: Journal of Hematology & Oncology 2018 11:110

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  38. Content type: Research

    No approved targeted agents are available for esophageal squamous cell carcinoma (ESCC). Informative genomic analysis and mouse patient-derived xenografts (PDX) also called mouse avatar can greatly expedite dr...

    Authors: Zhentao Liu, Zuhua Chen, Jingyuan Wang, Mengqi Zhang, Zhongwu Li, Shubin Wang, Bin Dong, Cheng Zhang, Jing Gao and Lin Shen

    Citation: Journal of Hematology & Oncology 2018 11:109

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  39. Content type: Research

    The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL).

    Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan and Jan Cools

    Citation: Journal of Hematology & Oncology 2018 11:108

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  40. Content type: Review

    Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress. In humans, MTs have four ma...

    Authors: Manfei Si and Jinghe Lang

    Citation: Journal of Hematology & Oncology 2018 11:107

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  41. Content type: Review

    Compared with normal cells, tumor cells display distinct metabolic characteristics. Long non-coding RNAs (lncRNAs), a large class of regulatory RNA molecules with limited or no protein-coding capacity, play ke...

    Authors: Hui Sun, Zhaohui Huang, Weiqi Sheng and Mi-die Xu

    Citation: Journal of Hematology & Oncology 2018 11:106

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  42. Content type: Research

    Next-generation sequencing (NGS) of the rearranged immunoglobulin heavy-chain gene has emerged as a highly sensitive method to detect minimal residual disease (MRD) in B acute lymphoblastic leukemia/lymphoma (...

    Authors: Shuhua Cheng, Giorgio Inghirami, Shuo Cheng and Wayne Tam

    Citation: Journal of Hematology & Oncology 2018 11:105

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  43. Content type: Letter to the Editor

    Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Current treatment strategies include the use of growth factors, CD34+-selected st...

    Authors: Cen Tang, Feng Chen, Danqing Kong, Qinfen Ma, Haiping Dai, Jia Yin, Zheng Li, Jia Chen, Xiaming Zhu, Xinliang Mao, Depei Wu and Xiaowen Tang

    Citation: Journal of Hematology & Oncology 2018 11:103

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  44. Content type: Research

    The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer...

    Authors: Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu and Hanmei Xu

    Citation: Journal of Hematology & Oncology 2018 11:102

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  45. Content type: Research

    Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4 anemia and/or thrombocytopenia, necessitating dose reductions a...

    Authors: Moshe Talpaz, Susan Erickson-Viitanen, Kevin Hou, Solomon Hamburg and Maria R. Baer

    Citation: Journal of Hematology & Oncology 2018 11:101

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