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  1. Results of conventional induction chemotherapies in primary central nervous system lymphoma (PCNSL) need to be improved. Ibrutinib, a BTK inhibitor, and lenalidomide, an immunomodulatory drug, have shown promi...

    Authors: Alcantara Marion, Chevrier Marion, Jardin Fabrice, Schmitt Anna, Houillier Caroline, Oberic Lucie, Chinot Olivier, Morschhauser Franck, Peyrade Frédéric, Houot Roch, Hoang-Xuan Khê, Ghesquieres Hervé and Soussain Carole
    Citation: Journal of Hematology & Oncology 2024 17:86
    Content type: Research Published on:

  2. Relapsed and refractory acute myeloid leukemia (AML) carries a dismal prognosis. CAR T cells have shown limited efficacy in AML, partially due to dysfunctional autologous T cells and the extended time for gene...

    Authors: David Sedloev, Qian Chen, Julia M. Unglaub, Nicola Schanda, Yao Hao, Eleni Besiridou, Brigitte Neuber, Anita Schmitt, Simon Raffel, Yi Liu, Maike Janssen, Carsten Müller-Tidow, Michael Schmitt and Tim Sauer
    Citation: Journal of Hematology & Oncology 2024 17:85
    Content type: Research Published on:

  3. Combination of immunotherapy with radiotherapy is under active investigation. The PACIFIC trial firmly established the treatment paradigm of consolidation immunotherapy following definitive chemoradiotherapy, ...

    Authors: Di Liu, Leilei Wu, Xiaoling Xu, Shuangyan Yang, Ming Liu, Min Hu, Shengxiang Ren and Yaping Xu
    Citation: Journal of Hematology & Oncology 2024 17:84
    Content type: Correspondence Published on:

  4. Macrophage-based cell therapy is promising in solid tumors, but the efficient acquisition of macrophages remains a challenge. Induced pluripotent stem cell (iPSC)-induced macrophages are a valuable source, but...

    Authors: Shanshan Li, Guoyu Chen, Xia Huang, Yingwen Zhang, Shuhong Shen, Haizhong Feng and Yanxin Li
    Citation: Journal of Hematology & Oncology 2024 17:83
    Content type: Research Published on:

  5. Unintended pregnancy for female patients with chronic myeloid leukemia (CML) raises the discussion of treatment choices due to the teratogenicity of tyrosine kinase inhibitor (TKI). We report 51 accidental pre...

    Authors: Yingling Zu, Huifang Zhao, Jianling Chen, Huibing Dang, Yanrong Shi, Lixin Liang, Shuhao Mei, Yongping Song and Yanli Zhang
    Citation: Journal of Hematology & Oncology 2024 17:82
    Content type: Correspondence Published on:

  6. Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing protein structures, facilitating the repair or degradation of damaged proteins, and maintaining proteostasis and ce...

    Authors: Wei-Fang Zuo, Qiwen Pang, Xinyu Zhu, Qian-Qian Yang, Qian Zhao, Gu He, Bo Han and Wei Huang
    Citation: Journal of Hematology & Oncology 2024 17:81
    Content type: Review Published on:

  7. Metabolic reprogramming provides tumors with an energy source and biofuel to support their survival in the malignant microenvironment. Extensive research into the intrinsic oncogenic mechanisms of the tumor mi...

    Authors: Fusheng Zhang, Yongsu Ma, Dongqi Li, Jianlei Wei, Kai Chen, Enkui Zhang, Guangnian Liu, Xiangyu Chu, Xinxin Liu, Weikang Liu, Xiaodong Tian and Yinmo Yang
    Citation: Journal of Hematology & Oncology 2024 17:80
    Content type: Review Published on:

  8. Blinatumomab has emerged as a promising component of first-line therapy for acute B-cell precursor lymphoblastic leukemia (BCP-ALL), bolstering treatment efficacy. To mitigate CD19 selection pressure and reduc...

    Authors: Jing Lu, Huiying Qiu, Ying Wang, Xin Zhou, Haiping Dai, Xuzhang Lu, Xiaofei Yang, Bin Gu, Ming Hong, Miao Miao, Ruinan Lu, Jun Wang, Qian Wu, Mengxing Xue, Yun Wang, Ailing Deng…
    Citation: Journal of Hematology & Oncology 2024 17:79
    Content type: Correspondence Published on:

  9. Ferroptosis, characterized by iron-dependent lipid peroxidation, emerges as a promising avenue for hepatocellular carcinoma (HCC) intervention due to its tumor susceptibility. RNA N6-methyladenosine (m6A) modi...

    Authors: Jialin Wang, Mengxi Xiu, Jin Wang, Yong Gao and Yandong Li
    Citation: Journal of Hematology & Oncology 2024 17:78
    Content type: Research Published on:

  10. Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug res...

    Authors: Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao…
    Citation: Journal of Hematology & Oncology 2024 17:77
    Content type: Research Published on:

  11. Soft tissue sarcomas (STS) have long been a formidable challenge in oncology, partly because of their rarity and diversity, which complicates large-scale studies and slows the advent of new treatments. Traditi...

    Authors: Mariella Spalato-Ceruso, Nathan El Ghazzi and Antoine Italiano
    Citation: Journal of Hematology & Oncology 2024 17:76
    Content type: Review Published on:

  13. Thyroid cancer (TC) is a significant global healthcare burden. However, the lack of comprehensive data has impeded our understanding of its global impact. We aimed to examine the burden of TC and its trends at...

    Authors: Tianjiao Zhou, Xiaoting Wang, Jingyu Zhang, Enhui Zhou, Chen Xu, Ying Shen, Jianyin Zou, Wen Lu, Kaiming Su, Weijun Huang, Hongliang Yi and Shankai Yin
    Citation: Journal of Hematology & Oncology 2024 17:74
    Content type: Correspondence Published on:

  15. The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, tr...

    Authors: Xiaojie Liu, Ting Peng, Miaochun Xu, Shitong Lin, Bai Hu, Tian Chu, Binghan Liu, Yashi Xu, Wencheng Ding, Li Li, Canhui Cao and Peng Wu
    Citation: Journal of Hematology & Oncology 2024 17:72
    Content type: Review Published on:

  16. Osteosarcomas are intricate cellular ecosystems, where heterotypic interactions significantly influence disease progression and therapeutic outcomes. Despite their importance, a detailed understanding of their...

    Authors: Xuejing Zheng, Xu Liu, Xinxin Zhang, Zhenguo Zhao, Wence Wu and Shengji Yu
    Citation: Journal of Hematology & Oncology 2024 17:71
    Content type: Correspondence Published on:

  17. Deletions and partial losses of chromosome 7 (chr7) are frequent in acute myeloid leukemia (AML) and are linked to dismal outcome. However, the genomic landscape and prognostic impact of concomitant genetic ab...

    Authors: Adriane Halik, Marlon Tilgner, Patricia Silva, Natalia Estrada, Robert Altwasser, Ekaterina Jahn, Michael Heuser, Hsin-An Hou, Marta Pratcorona, Robert K. Hills, Klaus H. Metzeler, Laurene Fenwarth, Anna Dolnik, Christine Terre, Klara Kopp, Olga Blau…
    Citation: Journal of Hematology & Oncology 2024 17:70
    Content type: Research Published on:

  18. Many therapies are available for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) after ≥ 2 lines of therapy, albeit with scant evidence on the comparative effectiveness of thes...

    Authors: Allison Rosenthal, Javier Munoz, Monika Jun, Tongsheng Wang, Alex Mutebi, Anthony Wang, Shibing Yang, Kojo Osei-Bonsu, Brian Elliott, Fernando Rivas Navarro, Junhua Yu, Samantha Brodkin, Mariana Sacchi and Andrew Ip
    Citation: Journal of Hematology & Oncology 2024 17:69
    Content type: Correspondence Published on:

  20. The interleukin-1 receptor accessory protein (IL1RAP) is highly expressed on acute myeloid leukemia (AML) bulk blasts and leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs), providin...

    Authors: Yi Zhang, Miso Park, Lucy Y. Ghoda, Dandan Zhao, Melissa Valerio, Ebtesam Nafie, Asaul Gonzalez, Kevin Ly, Bea Parcutela, Hyeran Choi, Xubo Gong, Fang Chen, Kaito Harada, Zhenhua Chen, Le Xuan Truong Nguyen, Flavia Pichiorri…
    Citation: Journal of Hematology & Oncology 2024 17:67
    Content type: Research Published on:

  21. Long non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as critical regulators of gene expression and key players in cancer biology. Recent breakthroughs have revealed that certain ...

    Authors: Yaguang Zhang
    Citation: Journal of Hematology & Oncology 2024 17:66
    Content type: Review Published on:

  22. The past few decades have witnessed the rise of immunotherapy for Gastrointestinal (GI) tract cancers. The role of immune checkpoint inhibitors (ICIs), particularly programmed death protein 1 (PD-1) and PD lig...

    Authors: Xiaoyi Chong, Yelizhati Madeti, Jieyuan Cai, Wenfei Li, Lin Cong, Jialin Lu, Liyang Mo, Huizhen Liu, Siyi He, Chao Yu, Zhiruo Zhou, Boya Wang, Yanshuo Cao, Zhenghang Wang, Lin Shen, Yakun Wang…
    Citation: Journal of Hematology & Oncology 2024 17:65
    Content type: Review Published on:

  24. Invasive fungal disease (IFD) presents a life-threatening condition in immunocompromised patients, thus often prompting empirical administration of antifungal treatment, without adequate mycological evidence. ...

    Authors: Chantal Lucini, Klára Obrová, Isabella Krickl, Filomena Nogueira, Iva Kocmanová, Susanne Herndlhofer, Karoline V. Gleixner, Wolfgang R. Sperr, Tijana Frank, Nuno Andrade, Christina Peters, Gernot Engstler, Michael Dworzak, Andishe Attarbaschi, Martine van Grotel, Marry M. van den Heuvel-Eibrink…
    Citation: Journal of Hematology & Oncology 2024 17:63
    Content type: Correspondence Published on:

  25. Due to the challenge for intratumoral administration, innate agonists have not made it beyond preclinical studies for efficacy testing in most tumor types. Pancreatic ductal adenocarcinoma (PDAC) has a hostile...

    Authors: Keyu Li, Junke Wang, Rui Zhang, Jiawei Zhou, Birginia Espinoza, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He…
    Citation: Journal of Hematology & Oncology 2024 17:62
    Content type: Correspondence Published on:

  26. Autologous anti-CD19 chimeric antigen receptor (CAR) T cells are now used in routine practice for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Severe (grade ≥ 3) cytokine release syndrome (CRS) and ...

    Authors: Pierre Sesques, Amy A. Kirkwood, Mi Kwon, Kai Rejeski, Michael D. Jain, Roberta Di Blasi, Gabriel Brisou, François-Xavier Gros, Fabien le Bras, Pierre Bories, Sylvain Choquet, Marie-Thérèse Rubio, Gloria Iacoboni, Maeve O’Reilly, René-Olivier Casasnovas, Jacques-Olivier Bay…
    Citation: Journal of Hematology & Oncology 2024 17:61
    Content type: Research Published on:

  27. The optimal treatment endpoints and duration of continuous therapy for multicentric Castleman disease (MCD) remain controversial. We retrospectively analyzed data from 123 patients with Human Herpesvirus (HHV)...

    Authors: Yi Liu, Xuejiao Yin, Shengnan Ding, Jiaying Ge, Liya Ma, Min Yang, Xuxia Luo, Chengli Zhong, Sishi Fang, Qiumei Yao, Li Zhu, Wenjuan Yu, Liping Mao, Juying Wei, Xingnong Ye, De Zhou…
    Citation: Journal of Hematology & Oncology 2024 17:60
    Content type: Correspondence Published on:

  29. Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence supports plasticity among subtypes with a bias toward...

    Authors: Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga and Charles M. Rudin
    Citation: Journal of Hematology & Oncology 2024 17:58
    Content type: Research Published on:

  30. Natural killer (NK) cell-based therapies have made great progress in treating both hematological and solid tumors. Their unique mechanism of action does not rely on antigen presentation to recognize and elimin...

    Authors: Xubo Gong, Lianjun Zhang, Xin He, Jing Yang, Xiang Li, Weiwei Liu, Bin Zhang, Zhihua Tao and Wenbin Qian
    Citation: Journal of Hematology & Oncology 2024 17:57
    Content type: Correspondence Published on:

  31. In 2022, two new classifications of myeloid neoplasms and acute leukemias were published: the 5th edition WHO Classification (WHO-HAEM5) and the International Consensus Classification (ICC). As with prior clas...

    Authors: Wenbin Xiao, Valentina Nardi, Eytan Stein and Robert P. Hasserjian
    Citation: Journal of Hematology & Oncology 2024 17:56
    Content type: Review Published on:

  32. Liquid biopsy, an advanced technology for analyzing body fluid samples, is gaining traction in cancer diagnostics and monitoring. Blood-based liquid biopsy, particularly focusing on cell-free DNAs (cf-DNAs), c...

    Authors: Xinming Su, Zeping Shan and Shiwei Duan
    Citation: Journal of Hematology & Oncology 2024 17:55
    Content type: Correspondence Published on:

  34. Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well as its use of endogenous mechanisms to achieve desired ends. However, off...

    Authors: Ziyun Cheng, Seth-Frerich Fobian, Elena Gurrieri, Mohamadreza Amin, Vito Giuseppe D’Agostino, Mojtaba Falahati, Sara Zalba, Reno Debets, María J. Garrido, Mesha Saeed, Ann L. B. Seynhaeve, Hayri E. Balcioglu and Timo L. M. ten Hagen
    Citation: Journal of Hematology & Oncology 2024 17:53
    Content type: Review Published on:

  36. In 2022, two updated classification systems for lymphoid neoplasms were published by the World Health Organization (WHO Classification of Haematolymphoid Tumours, 5th edition, referred to hereafter as WHO-HAEM...

    Authors: Judith A. Ferry, Brian Hill and Eric D. Hsi
    Citation: Journal of Hematology & Oncology 2024 17:51
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2024 17:75

  37. Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects....

    Authors: Swati Naik, Ying Li, Aimee C. Talleur, Subodh Selukar, Emily Ashcraft, Cheng Cheng, Renee M. Madden, Ewelina Mamcarz, Amr Qudeimat, Akshay Sharma, Ashok Srinivasan, Ali Y. Suliman, Rebecca Epperly, Esther A. Obeng, M. Paulina Velasquez, Deanna Langfitt…
    Citation: Journal of Hematology & Oncology 2024 17:50
    Content type: Research Published on:

  38. Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet ach...

    Authors: Rubing Zheng, Xiaojian Zhu and Yi Xiao
    Citation: Journal of Hematology & Oncology 2024 17:49
    Content type: Review Published on:

  39. It remains a substantial challenge to balance treatment efficacy and toxicity in geriatric patients with multiple myeloma (MM), primarily due to the dynamic nature of frailty. Here, we conducted a prospective ...

    Authors: Yingjie Zhang, Xinyue Liang, Weiling Xu, Xingcheng Yi, Rui Hu, Xintian Ma, Yurong Yan, Nan Zhang, Jingxuan Wang, Xiaoxiao Sun, Yufeng Zhu, Mengru Tian, Maozhuo Lan, Mengtuan Long, Yun Dai and Fengyan Jin
    Citation: Journal of Hematology & Oncology 2024 17:48
    Content type: Correspondence Published on:

  40. Esophageal cancer (EC) is a highly lethal disease lacking early detection approaches. We previously identified that OTOP2 and KCNA3 were specifically hypermethylated in circulating cell-free DNA from patients ...

    Authors: Yan Bian, Ye Gao, Han Lin, Chang Sun, Wei Wang, Siyu Sun, Xiuling Li, Zhijie Feng, Jianlin Ren, Hezhong Chen, Chaojing Lu, Jinfang Xu, Jun Zhou, Kangkang Wan, Lei Xin, Zhaoshen Li…
    Citation: Journal of Hematology & Oncology 2024 17:47
    Content type: Correspondence Published on:

  41. The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation. Under normal physiological conditions, the Wnt...

    Authors: Pan Song, Zirui Gao, Yige Bao, Li Chen, Yuhe Huang, Yanyan Liu, Qiang Dong and Xiawei Wei
    Citation: Journal of Hematology & Oncology 2024 17:46
    Content type: Review Published on:

  43. Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associated macrophages (TAMs). These specialized immune cells play crucial roles in tumour growt...

    Authors: Belén Toledo, Linrui Zhu Chen, María Paniagua-Sancho, Juan Antonio Marchal, Macarena Perán and Elisa Giovannetti
    Citation: Journal of Hematology & Oncology 2024 17:44
    Content type: Review Published on:

  44. Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-...

    Authors: Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka…
    Citation: Journal of Hematology & Oncology 2024 17:43
    Content type: Research Published on:

  45. Idecabtagene vicleucel (Ide-cel) has demonstrated excellent efficacy and durable responses in patients with relapsed/refractory multiple myeloma (RRMM). However, the outcomes with ide-cel in patients with extr...

    Authors: Saurabh Zanwar, Surbhi Sidana, Leyla Shune, Omar Castaneda Puglianini, Oren Pasvolsky, Rebecca Gonzalez, Danai Dima, Aimaz Afrough, Gurbakhash Kaur, James A. Davis, Megan Herr, Hamza Hashmi, Peter Forsberg, Douglas Sborov, Larry D. Anderson Jr, Joseph P. McGuirk…
    Citation: Journal of Hematology & Oncology 2024 17:42
    Content type: Research Published on:

  46. Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-...

    Authors: Fangquan Chen, Rui Kang, Daolin Tang and Jiao Liu
    Citation: Journal of Hematology & Oncology 2024 17:41
    Content type: Review Published on:

  47. Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it is extremely challengi...

    Authors: Pooya Farhangnia, Hossein Khorramdelazad, Hamid Nickho and Ali-Akbar Delbandi
    Citation: Journal of Hematology & Oncology 2024 17:40
    Content type: Review Published on:

  48. The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as...

    Authors: Pei Zhang, Lin Yue, QingQing Leng, Chen Chang, Cailing Gan, Tinghong Ye and Dan Cao
    Citation: Journal of Hematology & Oncology 2024 17:39
    Content type: Review Published on:

  49. Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously challenging to treat and outcomes are typically poor. Over the past two decades, clinical...

    Authors: Esther Wei Yin Chang, Ya Hwee Tan and Jason Yongsheng Chan
    Citation: Journal of Hematology & Oncology 2024 17:38
    Content type: Review Published on:

  50. Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC in...

    Authors: Mu-Qi Shi, Ying Xu, Xin Fu, De-Si Pan, Xian-Ping Lu, Yi Xiao and Yi-Zhou Jiang
    Citation: Journal of Hematology & Oncology 2024 17:37
    Content type: Review Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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