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  1. High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to sti...

    Authors: Shumin Wang and Yi Zhang

    Citation: Journal of Hematology & Oncology 2020 13:116

    Content type: Editorial

    Published on:

  2. Multiple myeloma (MM) patients with high cytogenetic risk have poor outcomes. In CASTOR, daratumumab plus bortezomib/dexamethasone (D-Vd) prolonged progression-free survival (PFS) versus bortezomib/dexamethaso...

    Authors: Katja Weisel, Andrew Spencer, Suzanne Lentzsch, Hervé Avet-Loiseau, Tomer M. Mark, Ivan Spicka, Tamas Masszi, Birgitta Lauri, Mark-David Levin, Alberto Bosi, Vania Hungria, Michele Cavo, Je-Jung Lee, Ajay Nooka, Hang Quach, Markus Munder…

    Citation: Journal of Hematology & Oncology 2020 13:115

    Content type: Research

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  3. Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has multiple functions. The tyrosine kinase EphA2, which belongs to the f...

    Authors: Ta Xiao, Yuhang Xiao, Wenxiang Wang, Yan Yan Tang, Zhiqiang Xiao and Min Su

    Citation: Journal of Hematology & Oncology 2020 13:114

    Content type: Review

    Published on:

  4. ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; ho...

    Authors: Irene Cosi, Annamaria Pellecchia, Emanuele De Lorenzo, Eugenio Torre, Michela Sica, Gabriella Nesi, Rosario Notaro and Maria De Angioletti

    Citation: Journal of Hematology & Oncology 2020 13:112

    Content type: Research

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  5. Immune checkpoint blockade (ICB) therapies such as anti-programmed death 1 (PD-1) and anti-CTLA-4 (cytotoxic T lymphocyte-associated protein 4) have dramatically transformed treatment in solid tumor oncology. ...

    Authors: Basit Salik, Mark J. Smyth and Kyohei Nakamura

    Citation: Journal of Hematology & Oncology 2020 13:111

    Content type: Review

    Published on:

  6. In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of pa...

    Authors: Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu and Si Shi

    Citation: Journal of Hematology & Oncology 2020 13:110

    Content type: Review

    Published on:

  7. Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including d...

    Authors: Yu-Meng Sun and Yue-Qin Chen

    Citation: Journal of Hematology & Oncology 2020 13:109

    Content type: Review

    Published on:

  8. Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity and poor survival outcome. Apart from the central role of genetic lesions, epigenetic anomalies have been identified as drivers in...

    Authors: Samrat Roy Choudhury, Cody Ashby, Ruslana Tytarenko, Michael Bauer, Yan Wang, Shayu Deshpande, Judith Den, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Faith E. Davies, Frits van Rhee, Gareth J. Morgan and Brian A. Walker

    Citation: Journal of Hematology & Oncology 2020 13:108

    Content type: Research

    Published on:

  9. As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy. Taking into account the many recent advances in DC biology, we discuss how DCs (1) recognize pathogenic anti...

    Authors: Yingying Wang, Ying Xiang, Victoria W. Xin, Xian-Wang Wang, Xiao-Chun Peng, Xiao-Qin Liu, Dong Wang, Na Li, Jun-Ting Cheng, Yan-Ning Lyv, Shu-Zhong Cui, Zhaowu Ma, Qing Zhang and Hong-Wu Xin

    Citation: Journal of Hematology & Oncology 2020 13:107

    Content type: Review

    Published on:

  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan and Guoming Su

    Citation: Journal of Hematology & Oncology 2020 13:106

    Content type: Correction

    Published on:

    The original article was published in Journal of Hematology & Oncology 2019 12:135

  11. Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1), programmed cell death ligand-1 (PD-L1), and others have shown potent clinical efficacy and have revolutionized the treatment protocols of ...

    Authors: Yu Chen, Min Gao, Zhaoqin Huang, Jinming Yu and Xiangjiao Meng

    Citation: Journal of Hematology & Oncology 2020 13:105

    Content type: Review

    Published on:

  12. Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3). ...

    Authors: Ran Duan, Wenfang Du and Weijian Guo

    Citation: Journal of Hematology & Oncology 2020 13:104

    Content type: Review

    Published on:

  13. Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to con...

    Authors: Yonghan He, Sajid Khan, Zhiguang Huo, Dongwen Lv, Xuan Zhang, Xingui Liu, Yaxia Yuan, Robert Hromas, Mingjiang Xu, Guangrong Zheng and Daohong Zhou

    Citation: Journal of Hematology & Oncology 2020 13:103

    Content type: Review

    Published on:

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sha-Sha Cheng, Guan-Jun Yang, Wanhe Wang, Chung-Hang Leung and Dik-Lung Ma

    Citation: Journal of Hematology & Oncology 2020 13:102

    Content type: Correction

    Published on:

    The original article was published in Journal of Hematology & Oncology 2020 13:26

  15. MicroRNAs (miRNAs) play important roles in cell proliferation, differentiation, and survival and may be useful for acute myeloid leukemia (AML) diagnosis and prognosis. In this study, we defined a novel miRNA,...

    Authors: Yan Jia, Wei Liu, Hui-En Zhan, Xiao-Ping Yi, Hui Liang, Qi-Li Zheng, Xin-Ya Jiang, Hai-Yan Zhou, Liang Zhao, Xie-Lan Zhao and Hui Zeng

    Citation: Journal of Hematology & Oncology 2020 13:101

    Content type: Letter to the Editor

    Published on:

  16. Both inflammasomes and autophagy have important roles in the intracellular homeostasis, inflammation, and pathology; the dysregulation of these processes is often associated with the pathogenesis of numerous c...

    Authors: Chaeuk Chung, Wonhyoung Seo, Prashanta Silwal and Eun-Kyeong Jo

    Citation: Journal of Hematology & Oncology 2020 13:100

    Content type: Review

    Published on:

  17. The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms involved in CDK7-mediated immune evasion are unclea...

    Authors: Jian Wang, Ruiguang Zhang, Zhenyu Lin, Sheng Zhang, Yaobing Chen, Jing Tang, Jiaxin Hong, Xiaoshu Zhou, Yan Zong, Yingzhuo Xu, Rui Meng, Shuangbing Xu, Li Liu, Tao Zhang, Kunyu Yang, Xiaorong Dong…

    Citation: Journal of Hematology & Oncology 2020 13:99

    Content type: Research

    Published on:

  18. Investigations of disease incidence, mortality, and disability-adjusted life years (DALYs) are valuable for facilitating preventive measures and health resource planning. We examined the tracheal, bronchus, an...

    Authors: Yujiao Deng, Peng Zhao, Linghui Zhou, Dong Xiang, Jingjing Hu, Yu Liu, Jian Ruan, Xianghua Ye, Yi Zheng, Jia Yao, Zhen Zhai, Shuqian Wang, Si Yang, Ying Wu, Na Li, Peng Xu…

    Citation: Journal of Hematology & Oncology 2020 13:98

    Content type: Research

    Published on:

  19. Cancer is a complex disease in which both genetic defects and microenvironmental components contribute to the development, progression, and metastasization of disease, representing major hurdles in the identif...

    Authors: Michele Zanoni, Michela Cortesi, Alice Zamagni, Chiara Arienti, Sara Pignatta and Anna Tesei

    Citation: Journal of Hematology & Oncology 2020 13:97

    Content type: Review

    Published on:

  20. CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending...

    Authors: Entsar Eladl, Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Rumina Musani, Wenming Chen, Aijun Liu and Hong Chang

    Citation: Journal of Hematology & Oncology 2020 13:96

    Content type: Review

    Published on:

  21. Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TC...

    Authors: Yonghan He, Raphael Koch, Vivekananda Budamagunta, Peiyi Zhang, Xuan Zhang, Sajid Khan, Dinesh Thummuri, Yuma T. Ortiz, Xin Zhang, Dongwen Lv, Janet S. Wiegand, Wen Li, Adam C. Palmer, Guangrong Zheng, David M. Weinstock and Daohong Zhou

    Citation: Journal of Hematology & Oncology 2020 13:95

    Content type: Research

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  22. The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths in the USA. Our institution has treated over 2000 COVID-19 patients during the pandemic in New York City. The pandemic dir...

    Authors: Bo Wang, Oliver Van Oekelen, Tarek H. Mouhieddine, Diane Marie Del Valle, Joshua Richter, Hearn Jay Cho, Shambavi Richard, Ajai Chari, Sacha Gnjatic, Miriam Merad, Sundar Jagannath, Samir Parekh and Deepu Madduri

    Citation: Journal of Hematology & Oncology 2020 13:94

    Content type: Research

    Published on:

  23. The phase 2 BRIGHT AML 1003 trial evaluated efficacy and safety of glasdegib + low-dose cytarabine (LDAC) in patients with acute myeloid leukemia ineligible for intensive chemotherapy. The multicenter, open-la...

    Authors: Jorge E. Cortes, Florian H. Heidel, Walter Fiedler, B. Douglas Smith, Tadeusz Robak, Pau Montesinos, Anna Candoni, Brian Leber, Mikkael A. Sekeres, Daniel A. Pollyea, Roxanne Ferdinand, Weidong Wendy Ma, Thomas O’Brien, Ashleigh O’Connell, Geoffrey Chan and Michael Heuser

    Citation: Journal of Hematology & Oncology 2020 13:92

    Content type: Research

    Published on:

  24. RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling t...

    Authors: Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan, Tao Xi, Xiaoman Li and Lufeng Zheng

    Citation: Journal of Hematology & Oncology 2020 13:90

    Content type: Review

    Published on:

  25. The oncolytic viruses have shown promising results for the treatment of multiple myeloma. However, the use of human viruses is limited by the patients’ antiviral immune response. In this study, we investigated...

    Authors: Valentina Marchica, Valentina Franceschi, Rosanna Vescovini, Paola Storti, Emanuela Vicario, Denise Toscani, Alessia Zorzoli, Irma Airoldi, Benedetta Dalla Palma, Nicoletta Campanini, Eugenia Martella, Cristina Mancini, Federica Costa, Gaetano Donofrio and Nicola Giuliani

    Citation: Journal of Hematology & Oncology 2020 13:89

    Content type: Research

    Published on:

  26. Due to acromegaly’s insidious onset and slow progression, its diagnosis is usually delayed, thus causing severe complications and treatment difficulty. A convenient screening method is imperative. Based on our...

    Authors: Yanguo Kong, Xiangyi Kong, Cheng He, Changsong Liu, Liting Wang, Lijuan Su, Jun Gao, Qi Guo and Ran Cheng

    Citation: Journal of Hematology & Oncology 2020 13:88

    Content type: Letter to the Editor

    Published on:

  27. Graft-versus-host disease (GVHD) remains a major contributor to mortality and morbidity after allogeneic stem-cell transplantation (allo-HSCT). The updated recommendations suggest that rabbit antithymocyte glo...

    Authors: Eolia Brissot, Myriam Labopin, Ian Moiseev, J. J. Cornelissen, Ellen Meijer, Gwendolyn Van Gorkom, Montserrat Rovira, Fabio Ciceri, Laimonas Griskevicius, Didier Blaise, Edouard Forcade, Martin Mistrik, Stephan Mielke, Claude Eric Bulabois, Riitta Niittyvuopio, Eric Deconinck…

    Citation: Journal of Hematology & Oncology 2020 13:87

    Content type: Research

    Published on:

  28. Chimeric antigen receptor T (CAR-T) cell therapy is regarded as an effective solution for relapsed or refractory tumors, particularly for hematological malignancies. Although the initially approved anti-CD19 C...

    Authors: Ruihao Huang, Xiaoping Li, Yundi He, Wen Zhu, Lei Gao, Yao Liu, Li Gao, Qin Wen, Jiang F. Zhong, Cheng Zhang and Xi Zhang

    Citation: Journal of Hematology & Oncology 2020 13:86

    Content type: Review

    Published on:

  29. Alpha-fetoprotein (AFP) is a widely used biomarker for hepatocellular carcinoma (HCC) early detection. However, low sensitivity and false negativity of AFP raise the requirement of more effective early diagnos...

    Authors: Shu Zhang, Yuming Liu, Jing Chen, Hong Shu, Siyun Shen, Yin Li, Xinyuan Lu, Xinyi Cao, Liangqing Dong, Jieyi Shi, Ya Cao, Xiaoying Wang, Jian Zhou, Yinkun Liu, Lei Chen, Jia Fan…

    Citation: Journal of Hematology & Oncology 2020 13:85

    Content type: Research

    Published on:

  30. In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in general, with a particular focus on adenoviruses. These serve as a model to elucidate how versatile viruses are, an...

    Authors: Otto Hemminki, João Manuel dos Santos and Akseli Hemminki

    Citation: Journal of Hematology & Oncology 2020 13:84

    Content type: Review

    Published on:

  31. VISTA (V-domain immunoglobulin suppressor of T cell activation) is a well-established immune regulatory receptor. However, pre-clinical investigations indicated more complicated influences of VISTA on cancer i...

    Authors: Xing Huang, Xiaozhen Zhang, Enliang Li, Gang Zhang, Xun Wang, Tianyu Tang, Xueli Bai and Tingbo Liang

    Citation: Journal of Hematology & Oncology 2020 13:83

    Content type: Review

    Published on:

  32. The landscape of multiple myeloma (MM) has changed considerably in the past two decades regarding new treatments, insight into disease biology and innovation in the techniques available to assess measurable re...

    Authors: Leire Burgos, Noemi Puig, Maria-Teresa Cedena, María-Victoria Mateos, Juan José Lahuerta, Bruno Paiva and Jesús F. San-Miguel

    Citation: Journal of Hematology & Oncology 2020 13:82

    Content type: Review

    Published on:

  33. Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therap...

    Authors: Minlin Jiang, Peixin Chen, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He and Caicun Zhou

    Citation: Journal of Hematology & Oncology 2020 13:81

    Content type: Review

    Published on:

  34. The Philadelphia chromosome (Ph), which leads to the creation and expression of the fusion gene product BCR-ABL, underlines the pathogenesis of chronic myelogenous leukemia (CML) and a fraction of adult and pe...

    Authors: Xinhua Xiao, Ping Liu, Donghe Li, Zhizhou Xia, Peihong Wang, Xiuli Zhang, Mingzhu Liu, Lujian Liao, Bo Jiao and Ruibao Ren

    Citation: Journal of Hematology & Oncology 2020 13:80

    Content type: Research

    Published on:

  35. Mantle cell lymphoma (MCL) is a rare, B cell non-Hodgkin’s lymphoma with highly heterogeneous clinical presentation and aggressiveness. First-line treatment consists of intensive chemotherapy with autologous s...

    Authors: Walter Hanel and Narendranath Epperla

    Citation: Journal of Hematology & Oncology 2020 13:79

    Content type: Review

    Published on:

  36. Mixed-lineage leukemia (MLL) gene rearrangements trigger aberrant epigenetic modification and gene expression in hematopoietic stem and progenitor cells, which generates one of the most aggressive subtypes of leu...

    Authors: Wen-Tao Wang, Tian-Qi Chen, Zhan-Cheng Zeng, Qi Pan, Wei Huang, Cai Han, Ke Fang, Lin-Yu Sun, Qian-Qian Yang, Dan Wang, Xue-Qun Luo, Yu-Meng Sun and Yue-Qin Chen

    Citation: Journal of Hematology & Oncology 2020 13:78

    Content type: Research

    Published on:

  37. Hippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism is still poorly understood. At present, the significance of the Hippo-YAP...

    Authors: Xiangxiang Zhou, Na Chen, Hongzhi Xu, Xiaoming Zhou, Jianhong Wang, Xiaosheng Fang, Ya Zhang, Ying Li, Juan Yang and Xin Wang

    Citation: Journal of Hematology & Oncology 2020 13:77

    Content type: Research

    Published on:

  38. Although research on the effects of comorbidities on coronavirus disease 2019 (COVID-19) patients is increasing, the risk of cancer history has not been evaluated for the mortality of patients with COVID-19.

    Authors: Yifan Meng, Wanrong Lu, Ensong Guo, Jia Liu, Bin Yang, Ping Wu, Shitong Lin, Ting Peng, Yu Fu, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Funian Lu…

    Citation: Journal of Hematology & Oncology 2020 13:75

    Content type: Research

    Published on:

  39. Melanoma patients who have detectable serum soluble NKG2D ligands either at the baseline or post-treatment of PD1/PDL1 blockade exhibit poor overall survival. Among families of soluble human NKG2D ligands, the...

    Authors: Fahmin Basher, Payal Dhar, Xin Wang, Derek A. Wainwright, Bin Zhang, Jeffrey Sosman, Zhe Ji and Jennifer D. Wu

    Citation: Journal of Hematology & Oncology 2020 13:74

    Content type: Research

    Published on:

  40. Here we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer....

    Authors: Marianna Vitiello, Monica Evangelista, Yang Zhang, Leonardo Salmena, Pier Paolo Pandolfi and Laura Poliseno

    Citation: Journal of Hematology & Oncology 2020 13:73

    Content type: Rapid communication

    Published on:

  41. Acute myeloid leukemia (AML) is a common leukemia subtype and has a poor prognosis. The risk of AML is highly related to age. In the context of population aging, a comprehensive report presenting epidemiologic...

    Authors: Ming Yi, Anping Li, Linghui Zhou, Qian Chu, Yongping Song and Kongming Wu

    Citation: Journal of Hematology & Oncology 2020 13:72

    Content type: Research

    Published on:

  42. Rituximab (R) plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is the current standard therapy for diffuse large B cell lymphoma (DLBCL). Obinutuzumab (G), a glycoengineered, type II anti...

    Authors: Laurie H. Sehn, Maurizio Martelli, Marek Trněný, Wenxin Liu, Christopher R. Bolen, Andrea Knapp, Deniz Sahin, Gila Sellam and Umberto Vitolo

    Citation: Journal of Hematology & Oncology 2020 13:71

    Content type: Rapid communication

    Published on:

  43. Recent years have witnessed major advances that have improved outcome of adults with acute lymphoblastic leukemia (ALL). The emergence of the concept of measurable residual disease has fine-tuned our prognosti...

    Authors: Bachar Samra, Elias Jabbour, Farhad Ravandi, Hagop Kantarjian and Nicholas J. Short

    Citation: Journal of Hematology & Oncology 2020 13:70

    Content type: Review

    Published on:

  44. The life expectancy of extensive-stage small cell lung (ES-SCLC) cancer patients has not improved in the last 2–3 decades until two recent trials (CASPIAN and IMpower133) showing the addition of anti-programme...

    Authors: Chengliang Huang, Gregory N. Gan and Jun Zhang

    Citation: Journal of Hematology & Oncology 2020 13:69

    Content type: Letter to the Editor

    Published on:

  45. CD8+ T cell trafficking to the tumor site is essential for effective colorectal cancer (CRC) immunotherapy. However, the mechanism underlying CD8+ T cell infiltration in colorectal tumor tissues is not fully unde...

    Authors: Dan Wang, Weina Yu, Jingyao Lian, Qian Wu, Shasha Liu, Li Yang, Feng Li, Lan Huang, Xinfeng Chen, Zhen Zhang, Aitian Li, Jinbo Liu, Zhenqiang Sun, Junxia Wang, Weitang Yuan and Yi Zhang

    Citation: Journal of Hematology & Oncology 2020 13:68

    Content type: Research

    Published on:

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